Validation
| Gene Symbol | Curated Descriptions | Cell Lines | Isolations | Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| KISS1R | Stemness markers and enhance proliferation,migration and invasion abilities of neighboring cells | MDA-MB-231,T47D | centrifugationand filtration | transmission electron microscopy | metastasis | 26528758 | ||
| hsa-miR-130a | Comparing the miRNAs in MDA-Exo to MCF-Exo showed a higher expression of tumorigenic mir-130a in MDA-Exo. it has been shown that mir-130a contribute to tumorigenesis of colon cancer by regulating TGB-β/Smad signaling | MCF7,MDA-MB231 | ultracentrifugation | electron microscopy | 24468161 | |||
| hsa-miR-1246 | Hsa-miR-1246 promotes cell proliferation,invasion and drug resistance by targeting CCNG2 in breast cancer | MDA-MB-231 | ultracentrifugation | scanning electron and confocal microscopy | metastasis | 29216623 | ||
| FTH1 | FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | MDA-MB-436,MDA-MB-231 | centrifugation | transmission electron microscopy | 24255815 | |||
| hsa-miR-210 | Hsa-miR-210 can proliferate endothelial cells and promote tumor growth and invasion | 4T1 | ExoQuick | transmission electron microscopy | metastasis | 28038441 | ||
| hsa-miR-31 | Hsa-miR-31 modulates MCF-7 cells growth by specially targeting the histone deacetylase 2 | MCF7 | centrifugation | transmission electron microscopy | 30916359 | |||
| hsa-miR-182 | Hsa-miR-182 expression and secretion changes with breast cancer cell line aggressiveness.dependent mechanism;detectable in exosomes from human sera and may be transferred between cells via a microvesicle-dependent mechanism | MDA-MB-231 | centrifugation | transmission electron microscopy | metastasis | 27446418 | ||
| hsa-miR-105 | Hsa-miR-105 has significantly up-regulated and has been extensively implicated in cancer progression | MDA-MB-231 | ultracentrifugation | electron microscopy | metastasis | 24735924 | ||
| NEUROD1 | Stemness markers and enhance proliferation,migration and invasion abilities of neighboring cells | MDA-MB-231,T47D | centrifugationand filtration | transmission electron microscopy | metastasis | 26528758 | ||
| MTDH | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 |