Validation

Gene Symbol Curated Descriptions Cell Lines Isolations Validations Control-case Tumor Stage & Subtype Clinical Use PMID
CD47 A differential CD47 expression in blood-derived individual circulating exosomes that is correlated with breast cancer status, demonstrating a great potential of individual exosome profiles in biomarker discovery MDA-MB-231,MCF-12A ultracentrifugation electron microscopy 50 breast cancer samples (case) 40 healthy samples (control) diagnosis 27819324
hsa-miR-93-5p Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence ExoQuick nanosight LM10 instrumen western blottingt 16 breast cancer plasma samples (case) 16 healthy plasma samples (control) Luminal (ER and/or PR + and HER2 -),HER2 (ER and/or PR +/- and HER2 +),TN (ER and PR and HER2 -) recurrence 29050253
BIRC5 Differential expression of exosomal-Survivin, particularly Survivin-2B, may serve as a diagnostic and/or prognostic marker ExoQuick kit laser-scanning confocal microscopy 40 breast cancer samples (case) 10 healthy samples (control) staging I-IV breast cancer early diagnostic 24620748
ADAM10 The mature ADAM10 in exosomes and its proteolytic activity is regulated by tetraspanins CD9, CD81, CD82, which was associated with breast cancer electron microscopy,flow cytometry 32 breast cancer patients (case) 30 healthy females (control) ER and/or PR +/- and HER2+/ -,triple-negative breast cancer,stages Il and III breast cancer 30678441
hsa-miR-145 Our study showed that serum-circulating miR-145, miR-155, and miR-382 are present in exosomes. These miRNAs were previously proposed as noninvasive biomarkers to distinguish between BC patients and healthy individuals ExoQuick exosome precipitation solution scanning electron Microscopy,atomic force microscopy, anoparticle tracking analysis 20 diagnosis of ductal carcinoma (case) 5 healthy donors (control) stages I, III, and IV breast cancer 30891102
HER2 The exosomal HER2 expression levels were almost consistent with that in tumor tissues assessed by immunohistochemical staining MCF7,MDA-MB-231 centrifugation transmission electron microscopy 19 breast cancer patients (case) early diagnosis 28369094
hsa-miR-223-3p Exosomal miR-223-3p may be a useful preoperative biomarker to identify the invasive lesions of DCIS patients diagnosed by biopsy MCF7 ultracentrifugation electron microscope 175 breast cancer patients (case) 3 healthy controls (control) ductal carcinoma in?situ (DCIS) breast cancer? early diagnosis 29805680
hsa-miR-21 Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer centrifugation ultracentrifugation and filtration or with the Exoquick-TC reagent (System Biosciences,Mountain View,CA,USA) electron microscopy,nanoparticle tracking analysis,and western blot 16 breast cancer plasma samples (case) 16 healthy plasma samples (control) ER+/-,PR+/-,HER2+/- stages II, III breast cancer 27608715
hsa-miR-1246 Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer ultracentrifugation, Exoquick-TC reagent (System Biosciences,Mountain View,CA,USA) electron microscopy,nanoparticle tracking analysis,and western blot 16 breast cancer plasma samples (case) 16 healthy plasma samples (control) ER+/-,PR+/-,HER2+/- stages II, III breast cancer 27608715
CDC42 Presumably aid in targeting the primary cancer cells to specific metastatic sites 4T1 ultracentrifugation transmission electron microscopy metastasis 29115712

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