Validation
| Gene Symbol | Curated Descriptions | Cell Lines | Isolations | Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-1246 | Hsa-miR-1246 promotes cell proliferation,invasion and drug resistance by targeting CCNG2 in breast cancer | MDA-MB-231 | ultracentrifugation | scanning electron and confocal microscopy | metastasis | 29216623 | ||
| hsa-miR-16 | Hsa-miR-16 is characterized by excessive release from breast cancer cells while retaining relatively low concentrations of miRNA in the cells and could be used to detect the presence of malignant cells in the body | MDA-MB-231,MCF7 | centrifugation | negative-staining electron microscopy | 22772984 | |||
| FRS2 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| FIBP | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| hsa-miR-122 | Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis | MDA-MB-231 | centrifugation | transmission electron microscope | metastasis | 25621950 | ||
| FTH1 | FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | MDA-MB-436,MDA-MB-231 | centrifugation | transmission electron microscopy | 24255815 | |||
| hsa-miR-130a-3p | Hsa-miR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells | MCF7,MDA-MB-231 | ExoQuick Exosomal Extraction Kit | contrast microscope | 29746865 | |||
| hsa-miR-16 | miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes | 4T1 | ExoQuick-TCTM(System Bioscience,Mountain View,CA) | confocal laser microscopy | 24391924 | |||
| GSTP1 | Affecting drug metabolism---Anthracycline/taxane-based neoadjuvant chemotherapy | MCF7 | ultracentrifugation | transmission electron microscopy | drug resistance | 28438694 | ||
| hsa-miR-106b | The mir-106b is found in higher levels in MCF-Eox as well, which can promote breast cancer invasion and metastasis by targeting BRMS1 and RB | MCF7,MDA-MB231 | ultracentrifugation | electron microscopy | 24468161 |