Validation
| Gene Symbol | Curated Descriptions | Cell Lines | Isolations | Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-328 | MDA-Exo also contains significant amounts of hsa-miR-328,which has been shown to target CD44,reduce cell adhesion,enhance cell migration and regulate capillary structure formation | MCF7,MDA-MB231 | ultracentrifugation | electron microscopy | metastasis | 24468161 | ||
| hsa-miR-100 | Target gene prediction and pathway analysis showed the involvement of miR-100, miR-222, and miR-30a in pathways implicated in cancer pathogenesis, membrane vesiculation and therapy failure，the transmition of chemoresistance by a horizontal transfer of miRNAs | MCF7 | ultracentrifugation | transmission electron microscopy | drug resistance | 24740415 | ||
| ITGB1 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| hsa-miR-30a | Target gene prediction and pathway analysis showed the involvement of miR-100, miR-222, and miR-30a in pathways implicated in cancer pathogenesis, membrane vesiculation and therapy failure，the transmition of chemoresistance by a horizontal transfer of miRNAs | MCF7 | ultracentrifugation | transmission electron microscopy | drug resistance | 24740415 | ||
| hsa-miR-128 | Hsa-miR-128 negatively regulates the level of Bax in MCF7recipient cells and inhibits cell proliferation | MCF7 | centrifugation | transmission electron microscopy,Nanoparticle Tracking Analysis | 27322220 | |||
| hsa-miR-122 | Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis | MDA-MB-231 | centrifugation | transmission electron microscope | metastasis | 25621950 | ||
| FRS2 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| hsa-miR-200 | Promote mesenchymal-to-epithelial transition and colonisation of metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 28038441 | ||
| hsa-miR-222 | Hsa-miR-222-rich D/exo could alter PTEN expression in acquired cells that may spread resistance capacity | MCF7 | ultracentrifugation | transmission electron microscopy | drug resistance | 24740415 | ||
| hsa-miR-210 | The hypoxically regulated miR-210 was identified to be present at elevated levels in hypoxic exosome fractions | MCF7,SKBR3,MDA-MB-231 | ultracentrifugation | electron microscopy | 22998595 |