Validation

Gene Symbol Curated Descriptions Cell Lines Isolations Validations Control-case Tumor Stage & Subtype Clinical Use PMID
hsa-miR-301a MCF-Exo contains a higher amount of hsa-miR-301a,and overexpression has been considered a negative prognostic indicator in lymph node-negative (LNN) invasive ductal breast cancer MCF7,MDA-MB231 ultracentrifugation electron microscopy metastasis 24468161
hsa-miR-31 Hsa-miR-31 modulates MCF-7 cells growth by specially targeting the histone deacetylase 2 MCF7 centrifugation transmission electron microscopy 30916359
hsa-miR-182 Hsa-miR-182 expression and secretion changes with breast cancer cell line aggressiveness.dependent mechanism;detectable in exosomes from human sera and may be transferred between cells via a microvesicle-dependent mechanism MDA-MB-231 centrifugation transmission electron microscopy metastasis 27446418
FIBP Presumably aid in targeting the primary cancer cells to specific metastatic sites 4T1 ultracentrifugation transmission electron microscopy metastasis 29115712
hsa-miR-10b Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells MDA-MB-231 centrifugation scanning electron and confocal microscopy metastasis 25428807
FTH1 FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) MDA-MB-436,MDA-MB-231 centrifugation transmission electron microscopy 24255815
hsa-miR-210 Hsa-miR-210 can proliferate endothelial cells and promote tumor growth and invasion 4T1 ExoQuick transmission electron microscopy metastasis 28038441
hsa-miR-223 MiR-223 promoted the invasion of breast cancer cells via the Mef2c-β-catenin pathway MDA-MB-231 ultracentrifugation electronic microscopy 21939504
GSTP1 Affecting drug metabolism---Anthracycline/taxane-based neoadjuvant chemotherapy MCF7 ultracentrifugation transmission electron microscopy drug resistance 28438694
hsa-miR-106b The mir-106b is found in higher levels in MCF-Eox as well, which can promote breast cancer invasion and metastasis by targeting BRMS1 and RB MCF7,MDA-MB231 ultracentrifugation electron microscopy 24468161

Pages