Validation
| Gene Symbol | Curated Descriptions | Cell Lines | Isolations | Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-301a | MCF-Exo contains a higher amount of hsa-miR-301a,and overexpression has been considered a negative prognostic indicator in lymph node-negative (LNN) invasive ductal breast cancer | MCF7,MDA-MB231 | ultracentrifugation | electron microscopy | metastasis | 24468161 | ||
| hsa-miR-31 | Hsa-miR-31 modulates MCF-7 cells growth by specially targeting the histone deacetylase 2 | MCF7 | centrifugation | transmission electron microscopy | 30916359 | |||
| hsa-miR-182 | Hsa-miR-182 expression and secretion changes with breast cancer cell line aggressiveness.dependent mechanism;detectable in exosomes from human sera and may be transferred between cells via a microvesicle-dependent mechanism | MDA-MB-231 | centrifugation | transmission electron microscopy | metastasis | 27446418 | ||
| FIBP | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| hsa-miR-10b | Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells | MDA-MB-231 | centrifugation | scanning electron and confocal microscopy | metastasis | 25428807 | ||
| FTH1 | FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | MDA-MB-436,MDA-MB-231 | centrifugation | transmission electron microscopy | 24255815 | |||
| hsa-miR-210 | Hsa-miR-210 can proliferate endothelial cells and promote tumor growth and invasion | 4T1 | ExoQuick | transmission electron microscopy | metastasis | 28038441 | ||
| hsa-miR-223 | MiR-223 promoted the invasion of breast cancer cells via the Mef2c-β-catenin pathway | MDA-MB-231 | ultracentrifugation | electronic microscopy | 21939504 | |||
| GSTP1 | Affecting drug metabolism---Anthracycline/taxane-based neoadjuvant chemotherapy | MCF7 | ultracentrifugation | transmission electron microscopy | drug resistance | 28438694 | ||
| hsa-miR-106b | The mir-106b is found in higher levels in MCF-Eox as well, which can promote breast cancer invasion and metastasis by targeting BRMS1 and RB | MCF7,MDA-MB231 | ultracentrifugation | electron microscopy | 24468161 |