ARF6
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| ARF6 | The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis | 19416474 | GEP100 (BRAG2) to be responsible for the Arf6 activation to induce invasion and metastasis, by directly binding to ligand-activated epidermal growth factor receptor (EGFR) | mechanism | BC/OC research |
| ARF6 | ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor | 25799492 | A role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration | mechanism | BC/OC research |
| ARF6 | Requirement for Arf6 in breast cancer invasive activities | 25799492 | GTP hydrolysis-defective mutant Arf6(Q67L) and the GTP-binding defective mutant Arf6(T27N) both blocked these invasive activities but not cell adhesion, suggesting the necessity of continued activation and cycling of the Arf6 GTPase cycle in invasion | mechanism | BC/OC research |
| ARF6 | Roles of Arf6 in cancer cell invasion, metastasis and proliferation | 28625359 | The ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6;the ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6 | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| ARF6 | Insulin Signaling (Homo sapiens) | Wikipathway |
| ARF6 | Ras Signaling (Homo sapiens) | Wikipathway |
| ARF6 | Ras Signaling (Homo sapiens) | Wikipathway |
| ARF6 | EGF/EGFR Signaling Pathway (Homo sapiens) | Wikipathway |
| ARF6 | Insulin Signaling (Homo sapiens) | Wikipathway |
| ARF6 | EGF/EGFR Signaling Pathway (Homo sapiens) | Wikipathway |
| ARF6 | Clathrin-mediated endocytosis (Homo sapiens) | Wikipathway |
| ARF6 | Clathrin-mediated endocytosis (Homo sapiens) | Wikipathway |
| ARF6 | Signaling by MET (Homo sapiens) | Wikipathway |
| ARF6 | Signaling by MET (Homo sapiens) | Wikipathway |