BARD1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| BARD1 | BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation | 31142030 | Substantial evidence for the association of a deleterious BARD1 mutation with BC as a low/moderate risk allele | mechanism | BC/OC research |
| BARD1 | BARD1, a possible biomarker for breast and ovarian cancer | 19959210 | A blood test based on BARD1, a protein that interacts with the breast cancer gene product BRCA1, is a promising candidate for fulfilling these conditions | mechanism | BC/OC research |
| BARD1 | Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers | 21393566 | Interactors of BRCA1/2 have been implicated as modifiers of BRCA1/2-associated cancer risk. Our finding that BARD1 does not contribute to this risk modification may focus research on other genes that do modify BRCA1/2-associated cancer risk | mechanism | BC/OC research |
| BARD1 | Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms | 26329992 | Germline mutations of BARD1 may predispose to breast and/or ovarian cancer | mechanism | BC/OC research |
| BARD1 | Dualistic Role of BARD1 in Cancer | 29292755 | Further evidence for a dualistic role came with the identification of BARD1 as a neuroblastoma predisposition gene in our genome wide association study which has demonstrated that single nucleotide polymorphisms in BARD1 can correlate with risk or can protect against cancer based on their association with the expression of FL and splice variants of BARD1 | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| BARD1 | R-HSA-5685938 | Reactome |
| BARD1 | R-HSA-5685942 | Reactome |
| BARD1 | R-HSA-5693554 | Reactome |
| BARD1 | R-HSA-5693565 | Reactome |
| BARD1 | R-HSA-5693568 | Reactome |
| BARD1 | R-HSA-5693571 | Reactome |
| BARD1 | R-HSA-5693579 | Reactome |
| BARD1 | R-HSA-5693607 | Reactome |
| BARD1 | R-HSA-5693616 | Reactome |
| BARD1 | R-HSA-69473 | Reactome |