PKN2
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| PKN2 | Protein kinase C inhibitor chelerythrine selectively inhibits proliferation of triple-negative breast cancer cells. | 28515445 | PKN2, one of the PKC subtypes, was highly expressed in TNBC cell lines, and knocking down PKN2 in TNBC cells inhibited colony formation and xenograft growth. This indicates that PKN2 is required for the survival of TNBC cells, and could be the target mediates the selective activity of chelerythrine. | biomarker | BC/OC research |
| PKN2 | PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway | 29368606 | The expression of PKN2 in colon cancer cells predicted a favorable prognosis and was associated with low M2 macrophage content in human colon cancer tissues. | biomarker | BC/OC research |
| PKN2 | PKN2 in colon cancer cells inhibits M2 phenotype polarization of tumor-associated macrophages via regulating DUSP6-Erk1/2 pathway | 29368606 | PKN2 suppresses the expression of IL4 and IL10 from colon cancer cells by inhibiting Erk1/2 phosphorylation, which is required for phosphorylation and binding of CREB and Elk-1 to the promoters of IL4 and IL10. DUSP6, which is phosphorylated and activated through direct association with PKN2, suppresses Erk1/2 activation. | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| PKN2 | hsa04151:PI3K-Akt signaling pathway | KEGG |
| PKN2 | hsa05132:Salmonella infection | KEGG |
| PKN2 | miR-targeted genes in lymphocytes - TarBase (Homo sapiens) | Wikipathway |
| PKN2 | miR-targeted genes in muscle cell - TarBase (Homo sapiens) | Wikipathway |
| PKN2 | RHO GTPases activate PKNs (Homo sapiens) | Wikipathway |
| PKN2 | PI3K-Akt Signaling Pathway (Homo sapiens) | Wikipathway |
| PKN2 | R-HSA-5625740 | Reactome |