MEF2A
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| MEF2A | The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro | 26403201 | In cells transformed by the oncogene HER2 (ERBB2), acini morphogenesis is altered, MEF2 transcription is repressed and HDAC7 is continuously expressed | mechanism | BC/OC research |
| MEF2A | The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness | 28419090 | In leiomyosarcomas (LMS), this two-faced trait of MEF2 is relevant for tumor aggressiveness | mechanism | BC/OC research |
| MEF2A | MEF2 signaling and human diseases | 29340119 | MEF2 family is closely associated with various signaling pathways, including Ca2+ signaling, MAP kinase signaling, Wnt signaling, PI3K/Akt signaling, etc. microRNAs also contribute to regulate the activities of MEF2 | mechanism | BC/OC research |
| MEF2A | MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells | 30514247 | Factors secreted by RENCA macrobeads significantly up-regulated the activity of the MEF2 transcription factor as well as altered the transcription of MEF2b and MEF2d isoforms in targeted tumor cells. Suppression of individual or multiple MEF2 isoforms in target tumor cells markedly reduced the growth inhibitory effects of RENCA macrobeads | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| MEF2A | R-HSA-198753 | Reactome |
| MEF2A | R-HSA-375170 | Reactome |
| MEF2A | hsa04022:cGMP-PKG signaling pathway | KEGG |
| MEF2A | Energy Metabolism (Homo sapiens) | Wikipathway |
| MEF2A | MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens) | Wikipathway |
| MEF2A | Myogenesis (Homo sapiens) | Wikipathway |
| MEF2A | NGF signalling via TRKA from the plasma membrane (Homo sapiens) | Wikipathway |
| MEF2A | SRF and miRs in Smooth Muscle Differentiation and Proliferation (Homo sapiens) | Wikipathway |
| MEF2A | miRs in Muscle Cell Differentiation (Homo sapiens) | Wikipathway |
| MEF2A | Cell Differentiation - Index expanded (Homo sapiens) | Wikipathway |