HDC
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| HDC | Histamine synthesis and content in benign and malignant breast tumours. Its effects on other host tissues | 7952401 | The HDC-activity of cancerous tissue was significantly higher (P < 0.01) than that registered in the healthy mammary gland tissue of the same patient, being even more pronounced in benign tumour tissue (P < 0.001) | mechanism | BC/OC research |
| HDC | Concentration of histamine in serum and tissues of the primary ductal breast cancers in women | 15927833 | The activity of HDC was significantly higher in cancerous tissues than in adjacent healthy tissues (54.7+/-17.1 vs. 34.5+/-24.3 pmol/min per mg; P<0.001), but there was no difference in the activity of DAO (14.0+/-6.4 vs. 14.4+/-10.9 pmol/min per mg) | mechanism | BC/OC research |
| HDC | The Role of Cyclooxygenase-2 in Mediating the Effects of Histamine on Cell Proliferation and Vascular Endothelial Growth Factor Production in Colorectal Cancer | 16203768 | Histidine decarboxylase activity and histamine content were also significantly higher in metastatic tumors than in nonmetastatic ones | mechanism | BC/OC research |
| HDC | Metabolism of histamine in tissues of primary ductal breast cancer | 19375125 | A significant increase in the concentration of histamine in plasma (P < .01) and tissues of ductal breast cancers (P < .001), and in the activity of histidine decarboxylase (P < .01), aromatic L-amino acids (P < .05), and histamine methyltransferase (P < .05) was found | mechanism | BC/OC research |
| HDC | Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer | 24835231 | Polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer | biomarker | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| HDC | R-HSA-70921 | Reactome |
| HDC | hsa00340:Histidine metabolism | KEGG |
| HDC | hsa01100:Metabolic pathways | KEGG |
| HDC | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism (Homo sapiens) | Wikipathway |
| HDC | Amino Acid metabolism (Homo sapiens) | Wikipathway |
| HDC | Biogenic Amine Synthesis (Homo sapiens) | Wikipathway |