ITGB1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| ITGB1 | β1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth and distinguishes malignant from normal phenotype in three dimensional cultures and?in vivo | 16452209 | Beta(1) integrin is a promising therapeutic target, and that the three-dimensional lrECM culture assay can be used to effectively distinguish malignant and normal tissue response to therapy | biomarker | BC/OC research |
| ITGB1 | β1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth and distinguishes malignant from normal phenotype in three dimensional cultures and?in vivo | 16452209 | ITGB1 inhibition resulted in a significant loss of cancer cells, associated with a decrease in proliferation and increase in apoptosis, and a global change in the composition of residual colonies | mechanism | BC/OC research |
| ITGB1 | Gene expression profiling combined with functional analysis identify integrin beta1 (ITGB1) as a potential prognosis biomarker in triple negative breast cancer | 26675717 | Gene expression profiling combined with functional analysis identify integrin beta1 (ITGB1) as a potential candidate biomarker for breast cancer cells migration, invasion and TNBC patients’ survival ?in triple negative?breast cancer | biomarker | BC/OC research |
| ITGB1 | Gene expression profiling combined with functional analysis identify integrin beta1 (ITGB1) as a potential prognosis biomarker in triple negative breast cancer | 26675717 | Silencing of ITGB1 inhibited TNBC cell migration, invasion and store-operated calcium influx | mechanism | BC/OC research |
| ITGB1 | β1 Integrin is essential for fascin‐mediated breast cancer stem cell function and disease progression | 30719702 | There was a significant relationship between fascin and ITGB1 co‐expression and short disease‐free as well as overall survival in chemo‐treated breast cancer patients | biomarker | BC/OC research |
| ITGB1 | β1 Integrin is essential for fascin‐mediated breast cancer stem cell function and disease progression | 30719702 | Fascin‐mediated regulation of ITGB1 was critical for several breast cancer cell functions including adhesion to different extracellular matrix, self‐renewability and chemoresistance. | mechanism | BC/OC research |
| ITGB1 | Tenascin C interacts with integrin receptors to promote breast cancer metastasis to the lungs | Link | Two integrin receptors of the mammary gland (ITGB1 and ITGB3) as the receptors mediating the TNC pro-metastatic signaling in triple-negative breast cancer | mechanism | BC/OC research |
| ITGB1 | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential | 29115712 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| ITGB1 | JAK/STAT (Homo sapiens) | Wikipathway |
| ITGB1 | Hair Follicle Development: Organogenesis (Part 2 of 3) (Homo sapiens) | Wikipathway |
| ITGB1 | Mammary gland development pathway - Embryonic development (Stage 1 of 4) (Homo sapiens) | Wikipathway |
| ITGB1 | Syndecan interactions (Homo sapiens) | Wikipathway |
| ITGB1 | Extracellular matrix organization (Homo sapiens) | Wikipathway |
| ITGB1 | Elastic fibre formation (Homo sapiens) | Wikipathway |
| ITGB1 | Pathogenic Escherichia coli infection (Homo sapiens) | Wikipathway |
| ITGB1 | Neural Crest Differentiation (Homo sapiens) | Wikipathway |
| ITGB1 | Arrhythmogenic Right Ventricular Cardiomyopathy (Homo sapiens) | Wikipathway |
| ITGB1 | Ebola Virus Pathway on Host (Homo sapiens) | Wikipathway |