POLR2K
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| POLR2K | Identification of Potential Driver Genes in Human Liver Carcinoma by Genomewide Screening | 19366792 | Of the 11 genes, 5 siRNAs for SCRIB, NCSTN, HSF1, TATDN1, and?POLR2K?significantly reduced the viability of both HepG2 and HuH-7 liver cancer cell lines | mechanism | BC/OC research |
| POLR2K | An integrative genomic and transcriptomic analysis reveals molecular pathways and networks regulated by copy number aberrations in basal-like, HER2 and luminal cancers | 19688261 | In HER2 cancers, the ‘Nucleotide Excision Repair Pathway’ was significantly enriched for genes whose expression correlates with copy number (P = 0.0214), with recurrent gains and amplifications of POLR2K and losses of RPA2 ( | mechanism | BC/OC research |
| POLR2K | The role of tumor metabolism as a driver of prostate cancer progression and lethal disease: results from a nested case-control study | 27980733 | Oxidative phosphorylation and pyrimidine metabolism were identified as the most dysregulated pathways in lethal tumors (p?<?0.007), and within these pathways, a number of novel differentially expressed genes were identified including?POLR2K?and?APT6V1A | mechanism | BC/OC research |
| POLR2K | Identification of miRNA biomarkers of pneumonia using RNA sequencing and bioinformatics analysis | 28413462 | POLR2K and APP were predicted targets of has-let-7f-1. The results of the present study demonstrated that has-let-7f-1 may serve a role in the development of cancer and the Notch signaling pathway | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| POLR2K | hsa03020:RNA polymerase | KEGG |
| POLR2K | R-HSA-77075 | Reactome |
| POLR2K | hsa00230:Purine metabolism | KEGG |
| POLR2K | hsa00240:Pyrimidine metabolism | KEGG |
| POLR2K | hsa01100:Metabolic pathways | KEGG |
| POLR2K | hsa05016:Huntington's disease | KEGG |
| POLR2K | mRNA Capping (Homo sapiens) | Wikipathway |
| POLR2K | hsa05169:Epstein-Barr virus infection | KEGG |
| POLR2K | R-HSA-76071 | Reactome |
| POLR2K | hsa04623:Cytosolic DNA-sensing pathway | KEGG |