ABCB1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| ABCB1 | Exosomes mediate drug resistance transfer in MCF7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein | 25077924 | Exosomes are effective in transferring drug resistance as well as P-gp from drug-resistant breast cancer cells to sensitive ones. The delivery of P-gp via exosomes may be a mechanism of exosome-mediated drug resistance transfer | mechanism | BCEXO research |
| ABCB1 | Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women | 19672706 | Genetic variants in ABCB1 and BRCA1 may modify the effect of Menopausal hormone therapy(HT) on postmenopausal breast cancer risk. | mechanism | BC/OC research |
| ABCB1 | Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide | 20179710 | Variant alleles in the ABCB1, SLC22A16 and CYP2B6 genes are associated with response to Doxorubicin and cyclophosphamide(AC) therapy in the treatment of breast cancer. | mechanism | BC/OC research |
| ABCB1 | The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment | 27175090 | ABCB1 gene may be potential candidate in pharmacogenetic evaluation of breast cancer treatment outcomes and optimizing individualized therapy. | biomarker | BC/OC research |
| ABCB1 | The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment | 27175090 | ABCB1 is highly polymorphic, and three well-known single-nucleotide polymorphisms such as 1236C>T, 2677G>T/A, and 3435C>T have been found to be associated with altered messenger RNA levels, protein folding, and drug pharmacokinetics.And these polymorphisms are found to be correlated with phenotypic variation in P-gp expression levels of various tissues.P-gp is widely expressed in the tissues essential in drug disposition such as the intestinal epithelium, adrenal glands, canalicular membrane of the hepatocytes of the liver, kidney proximal tubules, and blood–brain barrier.Major functions of P-gp proteins include the transport of drugs such as colchicine, tacrolimus, and quinidine; chemotherapeutic agents such as etoposide, doxorubicin, taxol, and vinblastine; and various lipids, bile salts, toxic compounds, and peptides for antigen presentation across the membranes. | mechanism | BC/OC research |
| ABCB1 | ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines | 27588398 | ABCB1 and ABCC11 expression may be used as a biomarker for predicting the response to eribulin in patients with breast cancer | biomarker | BC/OC research |
| ABCB1 | Loss of constitutive ABCB1 expression in breast cancer associated with worse prognosis | 28670140 | The loss of constitutive ABCB1 expression in breast cancer, especially in triple-negative tumors, seems to indicate a subgroup of worse prognosis. | biomarker | BC/OC research |
| ABCB1 | Development of high resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma | 31173253 | Our data suggest the existence of functional epigenetic changes in the ABCB1 gene with prognostic value in tumor tissues of patients with breast and ovarian carcinoma | biomarker | BC/OC research |
Survival analysis