hsa-miR-21
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| hsa-miR-21 | MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. | 18270520 | Mir-21 may promote tumor invasion and metastasis by simultaneously downregulating multiple metastasis-related tumor suppressor genes operating at distinct steps of tumor progression. | mechanism | BC/OC research |
| hsa-miR-21 | MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. | 18812439 | MiR-21 overexpression was correlated with specific breast cancer biopathologic features, such as advanced tumor stage, lymph node metastasis, and poor survival of the patients, indicating that miR-21 may serve as a molecular prognostic marker for BC and disease progression. | biomarker | BC/OC research |
| hsa-miR-21 | MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. | 18812439 | Among the 113 BC cases, high level expression of miR-21 was significantly correlated with advanced clinical stage (P = 0.006, Fisher's exact text), lymph node metastasis (P = 0.007, Fisher's exact text), and shortened survival of the patients (hazard ratio [HR]=5.476, P < 0.001). | mechanism | BC/OC research |
| hsa-miR-21 | High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. | 18932017 | High miR-21 was associated with poor disease-free survival in early stage patients (HR = 2.08, 95% CI: 1.08-4.00) despite no value for prognosis. | biomarker | BC/OC research |
| hsa-miR-21 | High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. | 18932017 | Elevated miR-21 expression may facilitate tumor progression, and TGF-beta may up-regulate its expression. | mechanism | BC/OC research |
| hsa-miR-21 | Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis | 25446899 | Hsa-miR-21 has significantly up-regulated and has been extensively implicated in cancer progression | mechanism | BCEXO research |
| hsa-miR-21 | Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy | 30728048 | Higher levels of exosomal miRNA-21, miRNA-222, and miRNA-155 were significantly associated with the presence of circulating tumor cells;Liquid biopsies based on exosomal miRNAs and circulating tumor cells can be a complementary clinical tool for improving breast cancer diagnosis and prognosis | biomarker | BCEXO research |
| hsa-miR-21 | Plasma exosome microRNAs are indicative of breast cancer | 27608715 | Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer | biomarker | BCEXO research |
Survival analysis
Pathways
| Enriched Terms | Cross Refer. |
|---|---|
| Dilated cardiomyopathy | KEGG |
| Glioma | KEGG |
| Prostate cancer | KEGG |
| Melanoma | KEGG |
| Bladder cancer | KEGG |
| Chronic myeloid leukemia | KEGG |
| Small cell lung cancer | KEGG |
| Acute myeloid leukemia | KEGG |
| Hypertrophic cardiomyopathy HCM | KEGG |
| Non small cell lung cancer | KEGG |