LDHA
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| LDHA | Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth | 19668225 | Overexpression of ErbB2 increased the expression of glycolysis-regulating molecules lactate dehydrogenase A (LDH-A) and heat shock factor 1 (HSF1). ErbB2 activated HSF1, indicated by the increased HSF1 trimer formation, and promoted HSF1 protein synthesis. HSF1 bound to LDH-A promoter and the downregulation of HSF1 reduced the expression of LDH-A and subsequently decreased cancer cell glycolysis and growth. | mechanism | BC/OC research |
| LDHA | High expressions of LDHA and AMPK as prognostic biomarkers for breast cancer | 27598996 | LDHA and AMPK as promising prognostic biomarkers for breast cancer. | biomarker | BC/OC research |
| LDHA | Tumor LDH-A expression and serum LDH status are two metabolic predictors for triple negative breast cancer brain metastasis | 28729678 | Tumor LDH-A expression, serum LDH status, and the slope of serum LDH status were closely associated with triple negative breast cancer brain metastasis and brain metastasis free survival. | mechanism | BC/OC research |
| LDHA | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential | 29115712 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| LDHA | hsa00010:Glycolysis / Gluconeogenesis | KEGG |
| LDHA | hsa00270:Cysteine and methionine metabolism | KEGG |
| LDHA | hsa00620:Pyruvate metabolism | KEGG |
| LDHA | hsa00640:Propanoate metabolism | KEGG |
| LDHA | hsa01100:Metabolic pathways | KEGG |
| LDHA | hsa01130:Biosynthesis of antibiotics | KEGG |
| LDHA | hsa04922:Glucagon signaling pathway | KEGG |
| LDHA | R-HSA-70268 | Reactome |