Validation
Gene Symbol |
Curated Descriptions | Cell Lines | Isolations | Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-93-5p | Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence | ExoQuick | nanosight LM10 instrumen western blottingt | 16 breast cancer plasma samples (case) 16 healthy plasma samples (control) | Luminal (ER and/or PR + and HER2 -),HER2 (ER and/or PR +/- and HER2 +),TN (ER and PR and HER2 -) | recurrence | 29050253 | |
| hsa-miR-939 | Hsa-miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers and an extracellular tumorigenic effect | MDA-MB-231 | ExoQuick-TC | confocal microscopy | triple-negative breast cancer | recurrence | 27693459 | |
| HTR7 | Stemness markers and enhance proliferation,migration and invasion abilities of neighboring cells | MDA-MB-231,T47D | centrifugationand filtration | transmission electron microscopy | metastasis | 26528758 | ||
| IGF1R | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| IL1RAP | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| ITGB1 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| KISS1R | Stemness markers and enhance proliferation,migration and invasion abilities of neighboring cells | MDA-MB-231,T47D | centrifugationand filtration | transmission electron microscopy | metastasis | 26528758 | ||
| KRT14 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| LDHA | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| MTDH | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 |