Validation
| Gene Symbol | Curated Descriptions | Cell Lines |
Isolations |
Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-191 | Preliminary data indicated that detection of cancer-specific miRNA (miR-103, miR-191, miR-195) in exosomes associated with the fraction of red blood cells allowed to discriminate HFs and BCPs more precisely compared to cell-free exosomes circulating in plasma | centrifugation | transmission electron microscopy | 10 patients (case) 10 healthy donors (control) | 30868953 | |||
| hsa-miR-195 | Preliminary data indicated that detection of cancer-specific miRNA (miR-103, miR-191, miR-195) in exosomes associated with the fraction of red blood cells allowed to discriminate HFs and BCPs more precisely compared to cell-free exosomes circulating in plasma | centrifugation | transmission electron microscopy | 10 patients (case) 10 healthy donors (control) | 30868953 | |||
| HER2 | The exosomal HER2 expression levels were almost consistent with that in tumor tissues assessed by immunohistochemical staining | MCF7,MDA-MB-231 | centrifugation | transmission electron microscopy | 19 breast cancer patients (case) | early diagnosis | 28369094 | |
| CD82 | CD82 expression in exosomes from breast cancer samples is a sensitive biomarker | centrifugation | western blot | 80 breast cancer patients (case) 80 patients with benign breast diseases (control) | stage 0 to stage IV | early diagnosis | 30604894 | |
| EEF1A1 | EEF1A1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | MDA-MB-436 ,MDA-MB-231 | centrifugation | transmission electron microscopy | 24255815 | |||
| FTH1 | FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | MDA-MB-436,MDA-MB-231 | centrifugation | transmission electron microscopy | 24255815 | |||
| FTL | FTL distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | MDA-MB-436,MDA-MB-231 | centrifugation | transmission electron microscopy | 24255815 | |||
| hsa-miR-10b | Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells | MDA-MB-231 | centrifugation | scanning electron and confocal microscopy | metastasis | 25428807 | ||
| hsa-miR-122 | Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis | MDA-MB-231 | centrifugation | transmission electron microscope | metastasis | 25621950 | ||
| hsa-miR-128 | Hsa-miR-128 negatively regulates the level of Bax in MCF7recipient cells and inhibits cell proliferation | MCF7 | centrifugation | transmission electron microscopy,Nanoparticle Tracking Analysis | 27322220 |