Validation
Gene Symbol | Curated Descriptions | Cell Lines | Isolations | Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
---|---|---|---|---|---|---|---|---|
hsa-miR-105 | Hsa-miR-105 has significantly up-regulated and has been extensively implicated in cancer progression | MDA-MB-231 | ultracentrifugation | electron microscopy | metastasis | 24735924 | ||
hsa-miR-10b | Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells | MDA-MB-231 | centrifugation | scanning electron and confocal microscopy | metastasis | 25428807 | ||
hsa-miR-122 | Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis | MDA-MB-231 | centrifugation | transmission electron microscope | metastasis | 25621950 | ||
hsa-miR-1246 | Hsa-miR-1246 promotes cell proliferation,invasion and drug resistance by targeting CCNG2 in breast cancer | MDA-MB-231 | ultracentrifugation | scanning electron and confocal microscopy | metastasis | 29216623 | ||
hsa-miR-182 | Hsa-miR-182 expression and secretion changes with breast cancer cell line aggressiveness.dependent mechanism;detectable in exosomes from human sera and may be transferred between cells via a microvesicle-dependent mechanism | MDA-MB-231 | centrifugation | transmission electron microscopy | metastasis | 27446418 | ||
hsa-miR-222 | Hsa-miR-222 contributes to tumorigenicity of BCa cells through down-regulation of PDLIM2 and consequently activating NF-κB | MDA-MB-231 | Exoquick Exosome Isolation Kit | transmission electron microscopy | metastasis | 29778754 | ||
hsa-miR-223 | MiR-223 promoted the invasion of breast cancer cells via the Mef2c-β-catenin pathway | MDA-MB-231 | ultracentrifugation | electronic microscopy | 21939504 | |||
hsa-miR-939 | Hsa-miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers and an extracellular tumorigenic effect | MDA-MB-231 | ExoQuick-TC | confocal microscopy | triple-negative breast cancer | recurrence | 27693459 | |
S1PR2 | S1P2 is released from breast cancer cells in exosomes and is processed by fibroblasts to promote ERK signaling and proliferation of breast cancer cells | MDA-MB-231 | ultracentrifugation | electron microscopy | 30034630 | |||
CD47 | A differential CD47 expression in blood-derived individual circulating exosomes that is correlated with breast cancer status, demonstrating a great potential of individual exosome profiles in biomarker discovery | MDA-MB-231,MCF-12A | ultracentrifugation | electron microscopy | 50 breast cancer samples (case) 40 healthy samples (control) | diagnosis | 27819324 |