Validation

Gene Symbol Curated Descriptions Cell Linessort descending Isolations Validations Control-case Tumor Stage & Subtype Clinical Use PMID
hsa-miR-105 Hsa-miR-105 has significantly up-regulated and has been extensively implicated in cancer progression MDA-MB-231 ultracentrifugation electron microscopy metastasis 24735924
hsa-miR-10b Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells MDA-MB-231 centrifugation scanning electron and confocal microscopy metastasis 25428807
hsa-miR-122 Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis MDA-MB-231 centrifugation transmission electron microscope metastasis 25621950
hsa-miR-1246 Hsa-miR-1246 promotes cell proliferation,invasion and drug resistance by targeting CCNG2 in breast cancer MDA-MB-231 ultracentrifugation scanning electron and confocal microscopy metastasis 29216623
hsa-miR-182 Hsa-miR-182 expression and secretion changes with breast cancer cell line aggressiveness.dependent mechanism;detectable in exosomes from human sera and may be transferred between cells via a microvesicle-dependent mechanism MDA-MB-231 centrifugation transmission electron microscopy metastasis 27446418
hsa-miR-222 Hsa-miR-222 contributes to tumorigenicity of BCa cells through down-regulation of PDLIM2 and consequently activating NF-κB MDA-MB-231 Exoquick Exosome Isolation Kit transmission electron microscopy metastasis 29778754
hsa-miR-223 MiR-223 promoted the invasion of breast cancer cells via the Mef2c-β-catenin pathway MDA-MB-231 ultracentrifugation electronic microscopy 21939504
hsa-miR-939 Hsa-miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers and an extracellular tumorigenic effect MDA-MB-231 ExoQuick-TC confocal microscopy triple-negative breast cancer recurrence 27693459
S1PR2 S1P2 is released from breast cancer cells in exosomes and is processed by fibroblasts to promote ERK signaling and proliferation of breast cancer cells MDA-MB-231 ultracentrifugation electron microscopy 30034630
CD47 A differential CD47 expression in blood-derived individual circulating exosomes that is correlated with breast cancer status, demonstrating a great potential of individual exosome profiles in biomarker discovery MDA-MB-231,MCF-12A ultracentrifugation electron microscopy 50 breast cancer samples (case) 40 healthy samples (control) diagnosis 27819324

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