Validation

Gene Symbol Curated Descriptions Cell Lines Isolations Validations Control-case Tumor Stage & Subtypesort ascending Clinical Use PMID
hsa-miR-100 Target gene prediction and pathway analysis showed the involvement of miR-100, miR-222, and miR-30a in pathways implicated in cancer pathogenesis, membrane vesiculation and therapy failure，the transmition of chemoresistance by a horizontal transfer of miRNAs MCF7 ultracentrifugation transmission electron microscopy drug resistance 24740415
hsa-miR-105 Hsa-miR-105 has significantly up-regulated and has been extensively implicated in cancer progression MDA-MB-231 ultracentrifugation electron microscopy metastasis 24735924
hsa-miR-106b The mir-106b is found in higher levels in MCF-Eox as well, which can promote breast cancer invasion and metastasis by targeting BRMS1 and RB MCF7,MDA-MB231 ultracentrifugation electron microscopy 24468161
hsa-miR-10b Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells MDA-MB-231 centrifugation scanning electron and confocal microscopy metastasis 25428807
hsa-miR-122 Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis MDA-MB-231 centrifugation transmission electron microscope metastasis 25621950
hsa-miR-1246 Hsa-miR-1246 promotes cell proliferation,invasion and drug resistance by targeting CCNG2 in breast cancer MDA-MB-231 ultracentrifugation scanning electron and confocal microscopy metastasis 29216623
hsa-miR-128 Hsa-miR-128 negatively regulates the level of Bax in MCF7recipient cells and inhibits cell proliferation MCF7 centrifugation transmission electron microscopy,Nanoparticle Tracking Analysis 27322220
hsa-miR-130a Comparing the miRNAs in MDA-Exo to MCF-Exo showed a higher expression of tumorigenic mir-130a in MDA-Exo. it has been shown that mir-130a contribute to tumorigenesis of colon cancer by regulating TGB-β/Smad signaling MCF7,MDA-MB231 ultracentrifugation electron microscopy 24468161
hsa-miR-130a-3p Hsa-miR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells MCF7,MDA-MB-231 ExoQuick Exosomal Extraction Kit contrast microscope 29746865
hsa-miR-16 Hsa-miR-16 is characterized by excessive release from breast cancer cells while retaining relatively low concentrations of miRNA in the cells and could be used to detect the presence of malignant cells in the body MDA-MB-231,MCF7 centrifugation negative-staining electron microscopy 22772984

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