Validation
| Gene Symbol | Curated Descriptions | Cell Lines |
Isolations |
Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| TRPC5 | CirExo-TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance | ultracentrifugation | Immunofluorescence confocal laser scanning microscope | 131 breast cancer female patients (case) | Anthracycline/taxane-based chemotherapy | 28032400 | ||
| Del-1 | As the current prospective cohort study demonstrated a normalization of exosomal Del-1 after curative surgery, exosomal Del-1 can be confirmed as a potent diagnostic biomarker for breast cancer. Plus, a high Del-1 level after surgery seems related with early relapse suggesting a potential prognostic marker by identifying the existence of residual tumor | ultracentrifugation | transmission electron microscopy | 114 breast cancer patients (case) | diagnosis | Link | ||
| hsa-miR-373 | Hsa-miR-373 has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-231,4T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-27a | Hsa-miR-27a has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-21 | Hsa-miR-21 has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-155 | Hsa-miR-155 has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-10b | Hsa-miR-10b has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-10a | Hsa-miR-10a has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| Dicer | Cancer exosomes induce tumor formation in a Dicer-dependent manner | MCF7,MDA-MB-231,4T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| UCHL1 | UCH-L1-containing exosomes can transfer chemoresistance to recipient cells and these exosomes may be useful as non-invasive diagnostic biomarkers for detection of chemoresitance in breast cancer patients, achieving more effective and individualized chemotherapy | MCF7 | ultracentrifugation | transmission electron microscopy | chemotherapy | 28334432 |