Validation
| Gene Symbol | Curated Descriptions | Cell Lines |
Isolations |
Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-373 | Hsa-miR-373 has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-231,4T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| Del-1 | As the current prospective cohort study demonstrated a normalization of exosomal Del-1 after curative surgery, exosomal Del-1 can be confirmed as a potent diagnostic biomarker for breast cancer. Plus, a high Del-1 level after surgery seems related with early relapse suggesting a potential prognostic marker by identifying the existence of residual tumor | ultracentrifugation | transmission electron microscopy | 114 breast cancer patients (case) | diagnosis | Link | ||
| TRPC5 | CirExo-TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance | ultracentrifugation | Immunofluorescence confocal laser scanning microscope | 131 breast cancer female patients (case) | Anthracycline/taxane-based chemotherapy | 28032400 | ||
| hsa-miR-223-3p | Exosomal miR-223-3p may be a useful preoperative biomarker to identify the invasive lesions of DCIS patients diagnosed by biopsy | MCF7 | ultracentrifugation | electron microscope | 175 breast cancer patients (case) 3 healthy controls (control) | ductal carcinoma in?situ (DCIS) breast cancer? | early diagnosis | 29805680 |
| hsa-miR-503 | Our data are the first to reveal the involvement of the endothelium in the modulation of tumor development via the secretion of circulating miR-503 in response to chemotherapy treatment | MDA-MB-231 | ultracentrifugation | electron microscopy | 29 breast cancer samples (case) | primary breast cancer | neoadjuvant chemotherapy | 25860935 |
| CD47 | A differential CD47 expression in blood-derived individual circulating exosomes that is correlated with breast cancer status, demonstrating a great potential of individual exosome profiles in biomarker discovery | MDA-MB-231,MCF-12A | ultracentrifugation | electron microscopy | 50 breast cancer samples (case) 40 healthy samples (control) | diagnosis | 27819324 | |
| POSTN | Periostin as a protein that is enriched in exosomes secreted by metastatic cells and validated its presence in a pilot cohort of breast cancer patient samples with localized disease or lymph node (LN) metastasis | MCF7,MDA-MB-231 | ultracentrifugation | electron microscopy | breast cancer samples (case) healthy samples (control) | primary breast cancer with lymph node metastasis at diagnosis | metastasis | 27589561 |
| ABCB1 | Exosomes are effective in transferring drug resistance as well as P-gp from drug-resistant breast cancer cells to sensitive ones. The delivery of P-gp via exosomes may be a mechanism of exosome-mediated drug resistance transfer | MCF7 | ultracentrifugation | electron microscopy | drug resistance | 25077924 | ||
| CDC42 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 | ||
| CP | Presumably aid in targeting the primary cancer cells to specific metastatic sites | 4T1 | ultracentrifugation | transmission electron microscopy | metastasis | 29115712 |