Validation
| Gene Symbol | Curated Descriptions | Cell Lines |
Isolations |
Validations | Control-case | Tumor Stage & Subtype | Clinical Use | PMID |
|---|---|---|---|---|---|---|---|---|
| hsa-miR-373 | In conclusion, our findings suggest cell-free miR-101 and miR-373 as breast cancer-specific markers | MCF7,MDA-MB-231 | ExoQuick exosome precipitation solution (BioCat,Heidelberg,Germany) | western blot (BioCat),BD Biosciences and Axiovert 200 microscope | 50 breast cancer samples (case) 12 healthy samples (control) | luminal,HER2(+),TN | 25333260 | |
| BIRC5 | Differential expression of exosomal-Survivin, particularly Survivin-2B, may serve as a diagnostic and/or prognostic marker | ExoQuick kit | laser-scanning confocal microscopy | 40 breast cancer samples (case) 10 healthy samples (control) | staging I-IV breast cancer | early diagnostic | 24620748 | |
| hsa-miR-939 | Hsa-miR-939 downregulates VE-cadherin and destroys the barrier function of endothelial monolayers and an extracellular tumorigenic effect | MDA-MB-231 | ExoQuick-TC | confocal microscopy | triple-negative breast cancer | recurrence | 27693459 | |
| hsa-miR-16 | miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes | 4T1 | ExoQuick-TCTM(System Bioscience,Mountain View,CA) | confocal laser microscopy | 24391924 | |||
| Dicer | Cancer exosomes induce tumor formation in a Dicer-dependent manner | MCF7,MDA-MB-231,4T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-10a | Hsa-miR-10a has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-10b | Hsa-miR-10b has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-155 | Hsa-miR-155 has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-21 | Hsa-miR-21 has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 | |
| hsa-miR-27a | Hsa-miR-27a has significantly up-regulated and has been extensively implicated in cancer progression | MCF7,MDA-MB-2314T1 | ultracentrifugation | transmission electron microscopy | 11 breast cancer samples (case) 8 healthy samples (control) | triple negative metastatic breast carcinoma | 25446899 |