Gene symble Title Curated description Category Literature category Pubmed ID ABCB1 Exosomes mediate drug resistance transfer in MCF7 breast cancer cells and a probable mechanism is delivery of P-glycoprotein Exosomes are effective in transferring drug resistance as well as P-gp from drug-resistant breast cancer cells to sensitive ones. The delivery of P-gp via exosomes may be a mechanism of exosome-mediated drug resistance transfer molecular function MFBCE 25077924 ABCB1 Polymorphisms in the BRCA1 and ABCB1 genes modulate menopausal hormone therapy associated breast cancer risk in postmenopausal women Genetic variants in ABCB1 and BRCA1 may modify the effect of Menopausal hormone therapy(HT) on postmenopausal breast cancer risk. molecular function CBC 19672706 ABCB1 Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide "Variant alleles in the ABCB1, SLC22A16 and CYP2B6 genes are associated with response to Doxorubicin and cyclophosphamide(AC) therapy in the treatment of breast cancer." molecular function CBC 20179710 ABCB1 The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment ABCB1 gene may be potential candidate in pharmacogenetic evaluation of breast cancer treatment outcomes and optimizing individualized therapy. biomarker CBC 27175090 ABCB1 The effect of ABCB1 polymorphisms on the outcome of breast cancer treatment "ABCB1 is highly polymorphic, and three well-known single-nucleotide polymorphisms such as 1236C>T, 2677G>T/A, and 3435C>T have been found to be associated with altered messenger RNA levels, protein folding, and drug pharmacokinetics.And these polymorphisms are found to be correlated with phenotypic variation in P-gp expression levels of various tissues.P-gp is widely expressed in the tissues essential in drug disposition such as the intestinal epithelium, adrenal glands, canalicular membrane of the hepatocytes of the liver, kidney proximal tubules, and blood–brain barrier.Major functions of P-gp proteins include the transport of drugs such as colchicine, tacrolimus, and quinidine; chemotherapeutic agents such as etoposide, doxorubicin, taxol, and vinblastine; and various lipids, bile salts, toxic compounds, and peptides for antigen presentation across the membranes. " molecular function CBC 27175090 ABCB1 ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines ABCB1 and ABCC11 expression may be used as a biomarker for predicting the response to eribulin in patients with breast cancer biomarker CBC 27588398 ABCB1 Loss of constitutive ABCB1 expression in breast cancer associated with worse prognosis "The loss of constitutive ABCB1 expression in breast cancer, especially in triple-negative tumors, seems to indicate a subgroup of worse prognosis." biomarker CBC 28670140 ABCB1 Development of high resolution melting analysis for ABCB1 promoter methylation: Clinical consequences in breast and ovarian carcinoma Our data suggest the existence of functional epigenetic changes in the ABCB1 gene with prognostic value in tumor tissues of patients with breast and ovarian carcinoma biomarker CBC 31173253 ABCB11 Description of two new ABCB11 mutations responsible for type 2 benign recurrent intrahepatic cholestasis in a French-Canadian family The present report describes two individuals from the same family whose symptoms were typical of the clinical characteristics of type 2 benign recurrent intrahepatic cholestasis. Sequencing of the?ABCB11?gene revealed two previously unreported mutations that predict the absence of expression of the protein molecular function CBC 21766090 ABCB11 The role of ABC transporters in progression and clinical outcome of colorectal cancer ABCC11 may be a promising candidate marker for a validation study on 5-FU therapy outcome biomarker CBC 22294766 ABCB11 Paediatric hepatocellular carcinoma due to somatic CTNNB1 and NFE2L2 mutations in the setting of inherited bi-allelic ABCB11 mutations This is the first study to identify somatic CTNNB1 and NFE2L2 mutations in early childhood arisen in the setting of inherited bi-allelic ABCB11 mutations molecular function CBC 25016225 ABCB5 ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma "Our findings show that ABCB5 is a novel molecular marker for a distinct subset of chemoresistant, stem cell phenotype-expressing tumor cells among melanoma bulk populations and indicate that these chemoresistant cells can be specifically targeted via ABCB5 to enhance cytotoxic efficacy" molecular function CBC 15899824 ABCB5 p-Glycoprotein ABCB5 and YB-1 expression plays a role in increased heterogeneity of breast cancer cells: correlations with cell fusion and doxorubicin resistance "Our work provides valuable insight into the drug induced cell fusion event and outcome, and suggests YB-1, GST, ABCB5 and ERK3 could be potential targets for the anti-cancer drug development against drug resistant breast cancer cells" molecular function CBC 20649952 ABCB5 Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres The potential clinical significance of our findings is based on the ability of parthenolide to affect both bulk and melanoma stem-like cells with clonogenic capacity and high expression of the ABCB5 transporter molecular function CBC 23192276 ABCB5 ¡÷Np73 regulates the expression of the multidrug-resistance genes ABCB1 and ABCB5 in breast cancer and melanoma cells - a short report "In addition, we found that exogenous expression of ¡÷Np73 led to an increase in the expression of ABCB1 and ABCB5 in the breast cancer-derived cell lines tested, while knocking down of ¡÷Np73 resulted in a reduction in ABCB1 and ABCB5 expression" molecular function CBC 28677036 ABCB5 ABCB5-ZEB1 Axis Promotes Invasion and Metastasis in Breast Cancer Cells "The expression of ZEB1 in tissues is positively relevant to ABCB5 in breast cancer. Knocking down ZEB1 inhibits ABCB5 ectopic expression-induced migration and invasion, as well as EMT" molecular function CBC 28281973 ABCC9 Gene expression of membrane transporters: Importance for prognosis and progression of ovarian carcinoma "ABCA2, ABCA9, ABCA10, ABCC9, ABCG2 and SLC16A14 present novel putative markers of EOC progression and together with the revealed relationship between ABCA12, ABCC3, ABCC6, ABCD3, ABCG1 and SLC22A5 expression, and high grade serous type of EOC should be further examined by larger follow-up study" molecular function CBC 26820484 AC092620.3 LncRNA expression profiling and its relationship with DNA damage in Cr (VI)-treated 16HBE cells "AC092620.3 were nonlinearly decreasing with the change of the DNA content of comet tails (Tail DNA), tail length (TLL), tail moment (TM) and Olive Tail Moment (OTM), and the fitting results of Tail DNA and TM were statistically significant (P?T, ETS2 rs461155A>G, SORBS1 rs7081076C>A and POLR2A rs2071504C>T could predict both chemotherapy response and survival" biomarker CBC 26893365 APC1 SCaMC-1 Promotes Cancer Cell Survival by Desensitizing Mitochondrial Permeability Transition via ATP/ADP-mediated Matrix Ca(2+) Buffering "Knockdown of APC1 increased cancer cell sensitivity to oxidative stress-induced?apoptosis, while its overexpression protected them from death;Selective inhibition of APC1 was thus suggested to be a promising anticancer strategy " molecular function CBC 22015608 ARF6 The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis "GEP100 (BRAG2) to be responsible for the Arf6 activation to induce invasion and metastasis, by directly binding to ligand-activated epidermal growth factor receptor (EGFR)" molecular function CBC 19416474 ARF6 ARF6 promotes the formation of Rac1 and WAVE-dependent ventral F-actin rosettes in breast cancer cells in response to epidermal growth factor A role for ARF6 in linking EGF-receptor signaling to Rac1 recruitment and activation at the plasma membrane to promote breast cancer cell directed migration molecular function CBC 25799492 ARF6 Requirement for Arf6 in breast cancer invasive activities "GTP hydrolysis-defective mutant Arf6(Q67L) and the GTP-binding defective mutant Arf6(T27N) both blocked these invasive activities but not cell adhesion, suggesting the necessity of continued activation and cycling of the Arf6 GTPase cycle in invasion" molecular function CBC 25799492 ARF6 "Roles of Arf6 in cancer cell invasion, metastasis and proliferation" The ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6;the ability of tumor invasion and metastasis can be suppressed when Arf6 activity is blocked by the inhibitors or small-interfering RNAs of Arf6 molecular function CBC 28625359 BARD1 "BARD1, a possible biomarker for breast and ovarian cancer" "A blood test based on BARD1, a protein that interacts with the breast cancer gene product BRCA1, is a promising candidate for fulfilling these conditions" molecular function CBC 19959210 BARD1 Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers Interactors of BRCA1/2 have been implicated as modifiers of BRCA1/2-associated cancer risk. Our finding that BARD1 does not contribute to this risk modification may focus research on other genes that do modify BRCA1/2-associated cancer risk molecular function CBC 21393566 BARD1 Cancer predisposing BARD1 mutations affect exon skipping and are associated with overexpression of specific BARD1 isoforms Germline mutations of BARD1 may predispose to breast and/or ovarian cancer molecular function CBC 26329992 BARD1 Dualistic Role of BARD1 in Cancer Further evidence for a dualistic role came with the identification of BARD1 as a neuroblastoma predisposition gene in our genome wide association study which has demonstrated that single nucleotide polymorphisms in BARD1 can correlate with risk or can protect against cancer based on their association with the expression of FL and splice variants of BARD1 molecular function CBC 29292755 BARD1 BARD1 is A Low/Moderate Breast Cancer Risk Gene: Evidence Based on An Association Study of the Central European p.Q564X Recurrent Mutation Substantial evidence for the association of a deleterious BARD1 mutation with BC as a low/moderate risk allele molecular function CBC 31142030 BDKRB2 Mitogenic signalling by B2 bradykinin receptor in epithelial breast cells The bradykininin receptor B2 (BDKRB2) gene is known to induce mitosis in breast cells and enhance progression of cancer. molecular function CBC 15281091 BDKRB2 Bradykinin stimulates cell proliferation through an extracellular-regulated kinase 1 and 2-dependent mechanism in breast cancer cells in primary culture "The mitogenic effects of BK are retained in peritumour and tumour cells; hence, it is likely that BK has an important role in cancer endorsement and progression." molecular function CBC 16079255 BDKRB2 Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines Tissue kallikrein was found in malignant human breast tissue and bradykinin (BK) stimulates the proliferation of immortalised breast cancer cells. molecular function CBC 19584277 BDKRB2 "CLOCK in breast tumorigenesis: genetic, epigenetic, and transcriptional profiling analyses" "BDKRB2 (2.1-fold decrease, Q = 1.63 E 3), which induces proliferation in human epithelial breast cells." molecular function CBC 20124474 BID Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis "We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in the Fas apoptotic signaling pathway" molecular function CBC 9727492 BID BID-deficient breast cancer MCF-7 cells as a model for the study of autophagy in cancer therapy BID(+) and BID(-) breast cancer MCF-7 cells could be considered to be a useful model for the study of the molecular interdependences between apoptosis and autophagy and the role of both processes in cancer therapy. molecular function CBC 16874058 BID Controlled delivery of BID protein fused with TAT peptide sensitizes cancer cells to apoptosis TAT-BID may be delivered to cancer cells in controlled manner and efficiently sensitizes PC3 and A549 cells to TRAIL molecular function CBC 25326334 BID Synergy of BID with doxorubicin in the killing of cancer cells TAT-BID and doxorubicin may thus be considered as a potential therapeutic combination for cervical carcinoma and advanced prostate cancer treatment molecular function CBC 25760094 BIRC5 Early diagnostic value of survivin and its alternative splice variants in breast cancer "Differential expression of exosomal-Survivin, particularly Survivin-2B, may serve as a diagnostic and/or prognostic marker" biomarker BBCE 24620748 BIRC5 The expression of BIRC5 is correlated with loss of specific chromosomal regions in breast carcinomas. BIRC5 expression may induce breast tumor proliferation by promoting genetic instability. biomarker CBC 18181175 BIRC5 BIRC5 Genomic Copy Number Variation in Early-Onset Breast Cancer BIRC5 gene has the potential to be a marker for the detection and prognosis of cancer at an early age. biomarker CBC 27372966 BIRC5 BIRC5 (survivin): a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy. BIRC5 (survivin) as a main pejorative prognostic factor in patients with breast cancers with no pCR. biomarker CBC 27592112 BIRC5 Downregulation of BIRC5 inhibits the migration and invasion of esophageal cancer cells by interacting with the PI3K/Akt signaling pathway "BIRC5 is able to inhibit the migration and invasion of tumor cells, and regulate the expression of angiogenesis?associated factors." biomarker CBC 30127937 BLZF1 A Role for the Nucleosome Assembly Proteins TAF-I¦Â and NAP1 in the Activation of BZLF1 Expression and Epstein-Barr Virus Reactivation "Quantification of the percentage of BLZF1-expressing cells showed that, like TAF-I¦Â, NAP1 overexpression can induce BZLF1 expression, whereas TAF-I¦Á overexpression did not induce BZLF1 expression, despite being expressed at a higher level than TAF-I¦Â" molecular function CBC 23691099 BLZF1 BLZF1 expression is of prognostic significance in hepatocellular carcinoma BLZF1 is a novel unfavorable biomarker for prognosis of patients with HCC biomarker CBC 26342799 BLZF1 BLZF1 expression is of prognostic significance in hepatocellular carcinoma The prognostic value of BLZF1 was further confirmed by stratified analyses molecular function CBC 26342799 CACNB2 Randomness and preserved patterns in cancer network "CACNB2 was downregulated in breast cancer cells, thereby causing poor signaling by negatively affecting the calcium metabolism" molecular function CBC 25220184 CASC3 Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines "The amplification of the HER2/TOP2A region has been correlated with the overexpression of several additional genes, such as CASC3, CDC6, RARA, and?SMARCE1" molecular function CBC 18332872 CASC3 Identification of Novel Breast Cancer Subtype-Specific Biomarkers by Integrating Genomics Analysis of DNA Copy Number Aberrations and miRNA-mRNA Dual Expression Profiling "?In the luminal-A loss related Bayesian network motif, BRCA1 showed the most links with other biomarkers, including two miRNAs (miR-143 and miR-145) and 4 genes (CASC3, ITGA2B, BID, and LMNB1)" molecular function CBC 25961039 CASC3 Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3 "MiR-124-1-mediated downregulation of CASC3 resulted in the inactivation of p38-MAPK, JNK and ERK" molecular function CBC 27029030 CASP7 "IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis" "This molecular signaling is associated with the activation of signal transducer and activator of transcription 1 and leads to increased mitochondrial membrane permeability; activation of caspase-7 (CASP7), CASP8, and CASP9; and induction of apoptosis but not autophagy. Whereas antiestrogen-resistant cells are capable of inducing autophagy through IFN-mediated signaling, their ability to do so through antiestrogen-regulated signaling is lost" molecular function CBC 20457620 CASP7 Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins Such pattern might be an indication of hsa-miR-29c miRNA functioning as a repressor of translation of CASP7 within the luminal-A subtype molecular function CBC 23562353 CASP7 Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies CASP3/DR combined with p19/p12-CASP7 accumulation correlated with the aggressive evolution of clinical malignancies and a poor prognosis in cancer patients molecular function CBC 23979166 CASP7 Overexpression of caspase 7 is ER¦Á dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip) "CASP7 is aberrantly expressed in breast cancer and contributes to cell growth and proliferation by downregulating p21(Cip) protein, suggesting that targeting CASP7-positive breast cancer could be one of the potential therapeutic strategies" molecular function CBC 27089142 CASP7 Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers "BCL2 levels are elevated in breast cancer where they are marker of good prognosis. BCL2 and active caspase levels correlate negatively; yet, active caspases indicate good outcome. Low BCL2 and low caspase-7 are highly prognostic of unfavourable outcome across all breast cancers. BCL2 levels indicate molecular subtype and tumour proliferation status in breast cancer" molecular function CBC 30069746 CCKBR A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer Single nucleotide polymorphism (SNP) in the cholecystokinin B receptor (CCKBR) gene predicts survival and risk of pancreatic cancer biomarker CBC 22277584 CCKBR A single nucleotide polymorphism of the cholecystokinin-B receptor predicts risk for pancreatic cancer Growth of human pancreatic cancer is stimulated by gastrin through the CCKBR and an alternatively spliced isoform of the CCKBR gene called CCKCR molecular function CBC 22277584 CCKBR MiR-148a regulates the growth and apoptosis in pancreatic cancer by targeting CCKBR and Bcl-2 MiR-148a's targeting of CCKBR and Bcl-2 in the regulation of pancreatic cancer growth and apoptosis molecular function CBC 23975374 CCKBR Heterogeneous expression of cholecystokinin and gastrin receptor in stomach and pancreatic cancer: An immunohistochemical study Significantly higher expression of CCKAR and down regulation of CCKBR in PC as compared to control while CCKBR/GR was detected in majority of SC samples molecular function CBC 27072272 CCKBR Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells All eight NENs expressed CCKBR and neuroendocrine markers in a majority of tumor cells molecular function CBC 28980157 CCKBR Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling "CCKBR/ERK/P65 signaling function is generally tumor suppressive in ER+ BC, indicating therapies should focus on restoring, not inhibiting, CCKBR/ERK/P65 pathway activity" molecular function CBC 30115027 CD24 Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage We suggest that CD24 could be an additional marker for the enrichment of tumor-derived exosomes from blood biomarker BBCE 21601258 CD24 CD24 expression is a new prognostic marker in breast cancer. CD24 expression in primary breast cancer as detected by immunohistochemistry might be a new marker for a more aggressive breast cancer biology. biomarker CBC 14581365 CD24 CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer. "CD24 overexpression is an independent unfavourable prognostic factor in breast cancer, especially for luminal A and TNBC subtypes, and CD24 may be a promising therapeutic target for specific subtypes of breast cancer." biomarker CBC 26444008 CD24 CD24 Overexpression Is Associated with Poor Prognosis in Luminal A and Triple-Negative Breast Cancer. "CD24 gene expression was associated with histone acetylation independent of DNA methylation, suggesting its epigenetic regulation in breast cancer." molecular function CBC 26444008 CD24 Prognostic significance of CD24 and CD44 in breast cancer: a meta-analysis. CD24 may play a role in tumorigenesis and cancer progression. biomarker CBC 27470135 CD24 CD24 is a Potential Biomarker for Prognosis in Human Breast Carcinoma. CD24 and SDC1 can serve as prognostic indicators for breast cancer. biomarker CBC 30001552 CD47 "A rapid,automated surface protein profiling of single circulating exosomes in human blood" "A differential CD47 expression in blood-derived individual circulating exosomes that is correlated with breast cancer status, demonstrating a great potential of individual exosome profiles in biomarker discovery" biomarker BBCE 27819324 CD47 HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells High CD47 expression is correlated with increased HIF target gene expression and decreased patient survival. biomarker CBC 26512116 CD47 HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells CD47 expression contributes to the lethal breast cancer phenotype that is mediated by HIF-1. molecular function CBC 26512116 CD47 Significance of CD47 expression in gastric cancer. "Low expression of CD47 was associated with the advancement of gastric cancer, in contrast to other cancers, and it may be associated with a decrease in lymphocytes during later stages." biomarker CBC 28693236 CD47 Combined high expression of CD47 and CD68 is a novel prognostic factor for breast cancer patients. "Combined detection of CD47 and CD68 may provide guidance for the prognosis of breast cancer, especially hormone receptor-negative breast cancer." biomarker CBC 31528120 CD47 Prognostic significance of CD47 in human malignancies: a systematic review and meta-analysis CD47 could be a useful prognostic indicator in cancer patients and may be a useful therapeutic target. biomarker CBC CD47 Role of the expression of PD-L1 and CD47 on circulating tumor cells (CTCs) in the prediction of outcome in metastatic breast cancer (mBC) patients. "The detection of high CD47 and/or PD-L1 expression on CTCs is associated with triple-negative tumors, disease progression and poor patient outcome and could serve for the refinement of prognosis in mBC." biomarker CBC CD82 Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer CD82 expression in exosomes from breast cancer samples is a sensitive biomarker biomarker BBCE 30604894 CD82 Correlation of reduction in MRP-1/CD9 and KAI1/CD82 expression with recurrences in breast cancer patients. The expression of MRP-1/CD9 and KAI1/CD82genes are useful indicators of a poor prognosis in breast cancer patients. biomarker CBC 9736046 CD82 Prognostic significance of KAI1/CD82 in human melanoma and its role in cell migration and invasion through the regulation of ING4. KAI1 may be used as a promising prognostic marker and a possible therapeutic target for human melanoma. biomarker CBC 24130172 CD82 Prognostic significance of KAI1/CD82 in human melanoma and its role in cell migration and invasion through the regulation of ING4. Overexpression of KAI1 significantly inhibited melanoma cell migration through suppression of Rho-associated kinase-mediated formation of stress fiber.overexpression of KAI1 significantly inhibited melanoma cell invasion by reducing the activity of metalloproteinase-2.melanoma cell migration by KAI1 is mediated by another tumor-suppressor protein called inhibitor of growth 4 through the regulation of p65. molecular function CBC 24130172 CD82 Effect and prognostic significance of the KAI1 gene in human gastric carcinoma. "The expression of KAI1 protein and mRNA was associated with the differentiation degree of gastric cancer, presence of lymph node metastasis, tumor-node-metastasis stage, depth of invasion and the survival time of patients.Patients that expressed KAI1 may demonstrate an improved prognosis." biomarker CBC 26622792 CD82 Effect and prognostic significance of the KAI1 gene in human gastric carcinoma. "The tumor suppressor gene KAI1 inhibits the migration and invasion of gastric carcinoma cells, possibly by suppressing the expression of uPA." molecular function CBC 26622792 CD82 Prognostic role of CD82/KAI1 in multiple human malignant neoplasms: a meta-analysis of 31 studies "CD82 could be a promising biomarker for predicting the prognosis of patients with malignant neoplasms, and the biological functions of CD82 are of great research value of the subject." biomarker CBC 29263677 CD82 Exosomal protein CD82 as a diagnostic biomarker for precision medicine for breast cancer. "CD82 expression in breast cancer tissue was significantly lower than that in healthy and benign breast disease tissues. There was a significant negative correlation between CD82 expression in tissues and CD82 content in exosomes, which indicated that CD82 expression was redistributed from tissues to the blood with the development and metastasis of breast cancer." biomarker CBC 30604894 CDC23 CDC23 regulates cancer cell phenotype and is overexpressed in papillary thyroid cancer "CDC23 is a critical regulator of cell cycle and cell growth, and may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender" molecular function CBC 21990323 CDC23 Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells "The levels of CDC23, an important mediator in mitotic progression, were suppressed following miR-34c expression, and siRNAs targeting CDC23 mimicked the effect of miR-34c on G2/M arrest" molecular function CBC 25064703 CDC23 Low-dose staurosporine selectively reverses BCR-ABL-independent IM resistance through PKC-¦Á-mediated G2/M phase arrest in chronic myeloid leukaemia "The PKC-¦Á-dependent G2/M phase arrest was induced by down-regulation of CDC23, an important regulator of mitotic progression" molecular function CBC 30618318 CDC42 Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential Presumably aid in targeting the primary cancer cells to specific metastatic sites molecular function MFBCE 29115712 CDC42 Role of Activated Rac1/Cdc42 in Mediating Endothelial Cell Proliferation and Tumor Angiogenesis in Breast Cancer Rac1/Cdc42 is a vascular regulator of tumor angiogenesis and that it may reduce stability of the p53 protein to promote VEGF expression by enhancing p53 protein ubiquitin. molecular function CBC 23750283 CDC42 Cdc42 overexpression induces hyperbranching in the developing mammary gland by enhancing cell migration "Cdc42 overexpression disrupts mammary gland branching morphogenesis by altering Rho GTPase and MAPK signaling, leading to increased MEC contractility and migration in association with stromal alterations" molecular function CBC 24074261 CDC42 Role of p-21-activated kinases in cancer progression "PAK1, MLC, ERK1/2 and Cyclin D1 are the downstream effectors of Cdc42. The expression of the PAKs can be seen in all sorts of tissues and plays an essential role in promoting tumorigenesis in various human neoplasms including breast cancer" molecular function CBC 24529727 CDC42 Silencing of CDC42 inhibits neuroblastoma cell proliferation and transformation CdcC42 induces invasiveness and metastatic activity by breast cancer cells molecular function CBC 25264923 CDC42 MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42 "MALAT1 influenced the expression of Cdc42 by binding miR-1 competitively. There were ceRNA networks that co-regulated cell migration and invasion in breast cancer patients by MALALT1, miR-1 and Cdc42of the PAKs can be seen in all sorts of tissues and plays an essential role in promoting tumorigenesis in various human neoplasms including?breast cancer?" molecular function CBC 26926567 CHEK2 Cancer risks in first-degree relatives of CHEK2 mutation carriers: effects of mutation type and cancer site in proband The risk of cancer in a carrier of a CHEK2 mutation is dependent on the family history of cancer molecular function CBC 19401704 CHEK2 Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer Women with a truncating mutation in CHEK2 and a positive family history of breast cancer have a lifetime risk of breast cancer of greater than 25% and are candidates for magnetic resonance imaging screening and for tamoxifen chemoprevention biomarker CBC 21876083 CHEK2 CHEK2 contribution to hereditary breast cancer in non-BRCAfamilies "CHEK2 alleles make an appreciable contribution to breast cancer susceptibility, and their identification could help in the clinical management of patients carrying a?CHEK2?mutation" molecular function CBC 22114986 CHEK2 Genomic Biomarkers for Breast Cancer Risk "Genomic biomarkers for breast cancer are comprised of rare highly penetrant mutations of genes such as BRCA1 or BRCA2, moderately penetrant mutations of genes such as?CHEK2, as well as more common genomic variants, including single nucleotide polymorphisms, associated with modest effect sizes" biomarker CBC 26987529 CHEK2 Prognostic Significance of CHEK2 Mutation in Progression of Breast Cancer Detection of mutations in CHEK2 can be used as a prognostic factor for patient response to treatment and for targeting downstream molecules of CHEK2 that are involved in the proliferation of breast tumor cells biomarker CBC 31220302 CP Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential Presumably aid in targeting the primary cancer cells to specific metastatic sites molecular function MFBCE 29115712 CP Evidence for increased non-ceruloplasmin copper in early-stage human breast cancer serum "This high serum copper-to-ceruloplasmin ratio in BC patients may reflect disordered copper metabolism in this disease, which could also have implications for the origin of, or the response to, the cancer proces" biomarker CBC 1584712 CP Use of ceruloplasmin levels to monitor response to therapy and predict recurrence of breast cancer "In following patients with breast cancer, we noted that in those patients that recurred, the CP level became elevated 16-34 weeks prior to any clinical evidence of metastases" molecular function CBC 6616078 CP Copper and ceruloplasmin levels in serum of women with breast cancer Levels copper and ceruloplasmin may help in prognosis & diagnosis of disease biomarker CBC 9808908 CP Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study "With 2D-nanoLC-MS/MS, afamin, apolipoprotein E and isoform 1 of inter-alpha trypsin inhibitor heavy chain H4 (ITIH4) were found to be higher in pre-diagnostic breast cancer (p < 0.05), while alpha-2-macroglobulin and ceruloplasmin were lower (p < 0.05" biomarker CBC 21871081 CP The relationship between serum level of copper and ceruloplasmin and pathologic and clinical characteristics in early breast cancer patients "Copper and ceruloplasmin might also play an important role in early procedure of breast cancer, and need collect more data in the future to validate" molecular function CBC CSTB Identification of Cystatin B as a Potential Serum Marker in Hepatocellular Carcinoma CSTB or the combination of CSTB and alpha-fetoprotein may be a useful marker for diagnosing patients with HCC with a high sensitivity biomarker CBC 18281540 CSTB Identification of Cystatin B as a Potential Serum Marker in Hepatocellular Carcinoma CSTB is specifically overexpressed in most HCCs and is also elevated in the serum of a large proportion of HCC patients molecular function CBC 18281540 CSTB Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-¦Â signaling pathway CSTB may become a novel diagnostic intracellular biomarker for the early detection of ovarian cancer biomarker CBC 24452274 CSTB Cystatin B is a progression marker of human epithelial ovarian tumors mediated by the TGF-¦Â signaling pathway The increased CSTB expression in ovarian tissue represents tumor progression and is dysregulated by the TGF-¦Â signaling pathway. molecular function CBC 24452274 CSTB Expression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer CSTB might be a potential prognostic marker for patients with primary lung cancer biomarker CBC 29037838 CSTB Expression and epigenetic regulation of cystatin B in lung cancer and colorectal cancer "In colorectal tumors, CSTB was not linked to any clinicopathological parameters including age, size of tumor, lymph node metastasis and tumor grading" molecular function CBC 29037838 CSTB Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer "Assessing the protein profiles of large and small neoplastic islands and their surrounding stroma by combining laser microdissection (LMD) and proteomics reveals several proteins-including CSTB, NDRG1, LTA4H, PGK1, COL6A1, ITGAV, and MB-ith distinct expression patterns between ITF and inner tumor, suggesting a potential prognostic value by clinicopathological association analysis" molecular function CBC 30185791 CTSB Cathepsin B: a potential prognostic marker for inflammatory breast cancer "CTSB may initiate proteolytic pathways crucial for IBC invasion. Thus, our data demonstrate that CTSB may be a potential prognostic marker for lymph node metastasis in IBC" molecular function CBC 21199580 CTSB Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression "IL-6-induced CTSB may play a role in lymph node metastasis, and that may possess future therapeutic implications for HRP-breast cancer patients with pLNs" molecular function CBC 27482469 CTSB TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA "SAHA may stimulate TRAIL DR5-CTSB crosstalk, influence the activity of downstream TOR signalling pathway mainly through the AKTs pathway, and initiate the autophagy of breast cancer cells" molecular function CBC 29018571 CTSB Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression TgCTSB and tgCTSL both display a strong and distinct impact on proteome composition of lung macrometastases in the PyMT model molecular function CBC 29187882 CTSB Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice "Double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation" molecular function CBC 20133781 CTSB ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression The identified signaling network activates the transcription of cathepsin B gene (CTSB) via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first?intron?of?CTSB molecular function CBC 22464443 CUL4A A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors CUL4A and CUL4B are therefore components of a conserved Wnt-induced proteasome targeting (WIPT) complex that regulates p27KIP1 levels and cell cycle progression in mammalian cells. molecular function CBC 19056892 CUL4A Analysis of DNA Repair-related Genes in Breast Cancer Reveals CUL4A Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response Our observations support the notion of greater trabectedin activity in tumors exhibiting BRCAness and reveal CUL4A as a potential biomarker for definition of trabectedin target patients biomarker CBC 23364677 CUL4A CUL4A?contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response "In particular, we report a putative role of CUL4A in bypassing the immune system in breast cancer through the down-regulation of several molecules involved in the immune surveillance. These findings provide insight into the oncogenic properties of CUL4A in basal-like breast cancer and highlight the therapeutic opportunities to target CUL4A" molecular function CBC 24870930 CUL4A Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer CUL4A and CUL4B are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes biomarker CBC 27974468 CUL4A CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma "Overexpression of CUL4A plays an oncogenic role in iCCA and adversely affects disease-free survival. Thus, it may prove to be a powerful prognostic factor and a potential therapeutic target" molecular function CBC 28576144 CUL4A miR-377 targets CUL4A and regulates metastatic capability in ovarian cancer MiR-377 is a significant negative regulator of CUL4A that controls cancer cell progression in ovarian cancer cell lines molecular function CBC 29512715 CXCL13 Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients "CXCL13 is overexpressed within breast cancer tissues, and increased serum levels of this cytokine can be found in breast cancer patients with metastatic disease pointing to a role of CXCL13 in the progression of breast cancer, suggesting that CXCL13 might serve as a useful therapeutic target and/or diagnostic marker in this malignancy" biomarker CBC 18781150 CXCL13 Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients CXCL13 is overexpressed within breast cancer tissues at the mRNA and protein levels and that increased serum levels of this cytokine can be found in breast cancer patients. molecular function CBC 18781150 CXCL13 Improved outcome of high-risk early HER2 positive breast cancer with high CXCL13-CXCR5 messenger RNA expression "CXCL13-CXCR5 axis with classic determinants of poor prognosis, such as high grade, hormone receptor negativity, and axillary node involvement." biomarker CBC 22607768 CXCL13 Improved outcome of high-risk early HER2 positive breast cancer with high CXCL13-CXCR5 messenger RNA expression "CXCL13 were found to be negatively associated with estrogen receptor and microtubule-associated protein tau mRNA expression and with dense lymphocytic infiltration, and were positively associated with nuclear grade. CXCL13 was positively associated with HER2. Multivariate analysis revealed an association between high CXCL13 mRNA expression and improved DFS (hazard ratio [HR] 0.48 [95% CI, 0.25-0.90]; Wald, P = .023) but not OS; In the HER2 mRNA overexpressing subgroup, high CXCL13 mRNA expression was associated with improved DFS (P < .001)." molecular function CBC 22607768 CXCL13 CXCL13-CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis "The EMT-inducing potential of CXCL13 as well as demonstrated the prognostic value of CXCL13-CXCR5 co-expression in primary BC. Moreover, CXCL13-CXCR5-RANKL-Src axis may present a therapeutic target in LNM positive BC patients" biomarker CBC 24337540 CXCL13 CXCL13-CXCR5 co-expression regulates epithelial to mesenchymal transition of breast cancer cells during lymph node metastasis "In CXCL13-stimulated BC cells, expression of various mesenchymal markers (Vimentin, N-cadherin), EMT regulators (Snail, Slug), and matrix metalloproteinase-9 (MMP9) was increased, whereas the expression of epithelial marker E-cadherin was found to be decreased. In addition, expression of receptor activator of nuclear factor kappa-B ligand (RANKL), which is known to regulate MMP9 expression via Src activation, was also significantly increased after CXCL13 stimulation. Using specific protein kinase inhibitors, we confirmed that CXCL13 stimulated EMT and MMP9 expression via RANKL-Src axis in BC cell lines. To further validate this observation, we examined gene expression patterns in primary breast tumors and detected significantly higher expression of various mesenchymal markers and regulators in CXCL13-CXCR5 co-expressing patients" molecular function CBC 24337540 CYC1 CYC1 Silencing Sensitizes Osteosarcoma Cells to TRAIL-Induced Apoptosis "CYC1 plays an important role in OS tumorigenesis, and modulation of CYC1 may be an effective strategy to potentiate OS to apoptotic induction by TRAIL" biomarker CBC 25562155 CYC1 CYC1 Predicts Poor Prognosis in Patients with Breast Cancer CYC1 plays crucial roles in breast cancer progression and might be a predictive factor assisting future patient diagnosis biomarker CBC 27239088 CYC1 Genomic alterations underlie a pan-cancer metabolic shift associated with tumour hypoxia "These subtype-specific breast cancer metabolism signatures contained a common set of five genes (SQLE, PYCRL, TSTA3, CYC1 and SLC39A4) which were co-amplified with?MYC?on chromosome 8q24 and showed a positive correlation with hypoxia" molecular function CBC 27358048 CYC1 Cytochrome c1 in ductal carcinoma in situ of breast associated with proliferation and comedo necrosis CYC1 plays important roles in cell proliferation and comedo necrosis through the elevated oxidative phosphorylation activity in human DCIS molecular function CBC 28394473 CYP11A1 Population-based case-control study of CYP11A gene polymorphism and breast cancer risk The TAAAA repeat polymorphism near the promoter region of the CYP11A gene may be an important susceptibility factor for breast cancer risk. molecular function CBC 15159300 CYP11A1 Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women Our findings support the possibility that common allelic variation at the CYP11A1 D15S520 locus alters breast cancer risk in Chinese women. molecular function CBC 18483327 CYP11A1 Risk-Association of CYP11A1 Polymorphisms and Breast Cancer Among Han Chinese Women in Southern China Polymorphisms of CYP11A1 are related to breast cancer susceptibility in Han Chinese women of South China. molecular function CBC 22606018 CYP19A1 "Positive Association of Polymorphisms in Estrogen Biosynthesis Gene, CYP19A1, and Metabolism, GST, in Breast Cancer Susceptibility" "The effect of CYP19A1 T/C polymorphism in susceptibility to breast cancer development can be modulated by the presence of GSTM1 and GSTT1, but not GSTP1" molecular function CBC 22300440 CYP19A1 SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression "SIRT1 occupies the promoter regions PI.3/PII and PI.4, and its inhibition leads to increased acetylation of estrogen-related receptorα, a transcription factor that positively regulates CYP19A1 transcription in epithelial cells" molecular function CBC 23340254 CYP19A1 Influence of CYP19A1 polymorphisms on the treatment of breast cancer with aromatase inhibitors: a systematic review and meta-analysis "The effects of CYP19A1 polymorphisms on clinical outcomes were most often detected in individual studies, suggesting that longer-term studies will better clarify these associations" molecular function CBC 26067721 CYP19A1 The rs4646 and rs12592697 Polymorphisms in CYP19A1?Are Associated with Disease Progression among Patients with Breast Cancer from Different Racial/Ethnic Backgrounds "The rs4646 and the rs12592697 SNPs in CYP19A1 are associated with differences in disease progression in postmenopausal women. However, treatment appears to mitigate the differences in genetic risk." molecular function CBC 27994616 CYP19A1 Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ER¦Á metastatic breast cancer AI treatment itself selects for acquired CYP19A1amp and promotes local autocrine estrogen signaling in AI-resistant metastatic patients molecular function CBC 28112739 DCT The Role of DCT/TYRP2 in Resistance of Melanoma Cells to Drugs and Radiation Melanoma cells expressing very low levels of DCT are highly susceptible to either type of treatment. Overexpression of DCT in melanoma cells by transfection could confer both radioresistance and chemoresistance molecular function CBC Del-1 Exosomal Del-1 as a potent diagnostic marker for breast cancer: A prospective cohort study "As the current prospective cohort study demonstrated a normalization of exosomal Del-1 after curative surgery, exosomal Del-1 can be confirmed as a potent diagnostic biomarker for breast cancer. Plus, a high Del-1 level after surgery seems related with early relapse suggesting a potential prognostic marker by identifying the existence of residual tumor" biomarker BBCE Del-1 Identification of Developmental Endothelial Locus-1 on Circulating Extracellular Vesicles as a Novel Biomarker for Early Breast Cancer Detection. Del-1 on circulating EVs is a promising marker to improve identification of patients with early-stage breast cancer and distinguish breast cancer from benign breast tumors and noncancerous diseases. biomarker CBC 26603257 Del-1 Del-1 Expression as a Potential Biomarker in Triple-Negative Early Breast Cancer. "Based on its relationship to an unfavorable histology and worse survival trend, Del-1 could act as a molecular target in TNBC patients." biomarker CBC 29393238 Del-1 Del-1 Expression as a Potential Biomarker in Triple-Negative Early Breast Cancer. "A correlation was found between Del-1 expression and an aggressive histological grade, nuclear mitosis, and polymorphism, suggesting a possible role in tumor progression." molecular function CBC 29393238 Del-1 Exosomal Del-1 as a potent diagnostic marker for breast cancer: A prospective cohort study. Exosomal Del-1 can be confirmed as a potent diagnostic biomarker for breast cancer. biomarker CBC Del-1 Del-1 promotes the proliferation and migration of tamoxifen-resistant MCF7 breast cancer cells The expression of Del-1 promote tamoxifen resistance in breast cancer celils and coud be a novel targed for anti-breast cancer treatment biomarker CBC Del-1 Del-1 promotes the proliferation and migration of tamoxifen-resistant MCF7 breast cancer cells Down-regulation of Del-1 inhibited the proliferation and migration of TAM MCF 7 cells. molecular function CBC Dicer Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Cancer exosomes induce tumor formation in a Dicer-dependent manner molecular function MFBCE 25446899 Dicer Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype. Assessment of Dicer expression may facilitate prediction of distant metastases for patients suffering from breast cancer. biomarker CBC 19672267 Dicer Dysregulated expression of dicer and drosha in breast cancer. The decreased expression of Dicer and Drosha may play a role in down-regulation of miRNAs in breast cancer. biomarker CBC 21898071 Dicer Loss of Dicer expression is associated with breast cancer progression and recurrence. "Dicer protein plays a role in human BC progression and behaviour, and assessment of its expression could provide prognostic information in BC including the HER2-positive class.In invasive BC, loss of Dicer expression was associated with features of aggressive behaviour including higher histological grade, loss of hormone receptor and BRCA1 protein expression and with shorter disease-free survival (DFS). Moreover, loss of Dicer was predictive of better response to chemotherapy and to endocrine therapy." biomarker CBC 22821364 Dicer Prognostic Significance of Deregulated Dicer Expression in Breast Cancer Dicer is an important prognostic marker in breast cancer and that its prognostic role may be subtype specific. biomarker CBC 24386264 DMRT1 Genomic and Expression Profiling of Human Spermatocytic Seminomas: Primary Spermatocyte as Tumorigenic Precursor and DMRT1 as Candidate Chromosome 9 Gene "Based on the region of amplification defined on 9p and the associated expression plus confirmatory immunohistochemistry, DMRT1 (a male-specific transcriptional regulator) was identified as a likely candidate gene for involvement in the development of spermatocytic seminomas" molecular function CBC 16397242 DMRT1 "Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer" "A locus on chromosome 9 (rs755383, OR=1.37, P=1.12x10(-23)), containing the sex determination gene DMRT1, which has been linked to teratoma susceptibility in mice" molecular function CBC 20543847 DMRT1 A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility "In combined analysis that mutually conditions on both DMRT1 single nucleotide polymorphism markers, TGCT cases had elevated odds of carriage of the rs7040024 major A allele [per-allele odds ratio (OR) = 1.48, 95% confidence interval (CI) 1.23, 1.78; P = 2.52 × 10(-5)] compared with controls, while the association with rs755383 persisted (per allele OR = 1.26, 95% CI 1.08, 1.47, P = 0.0036)" molecular function CBC 21551455 DMRT1 "Associations between variants in?KITLG,?SPRY4,?BAK1, and?DMRT1?and pediatric germ cell tumors" "Recent genome wide association studies have identified susceptibility loci for adult testicular germ cell tumors (GCT) near KITLG, SPRY4, BAK1, and DMRT1" molecular function CBC 22072546 DMRT1 Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line "Involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease" molecular function CBC 23473982 DOK1 "Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer" "These analyses were also indicative for DOK1 protective role in EOC tumorigenesis, linked to DOK1-mediated induction of some tumor suppressor factors and its suppression of pro-metastasis genes" molecular function CBC 21856257 DOK1 Transcriptional regulation of the human tumor suppressor DOK1 by E2F1 E2F1 is a key factor in DOK1 expression and provide novel insights into the regulation of these events in cancer cells molecular function CBC 23028047 DOK1 BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration "A novel mechanism of action of BRK in the promotion of tumor formation, which involves the targeting of tumor suppressor Dok1 for degradation through the ubiquitin proteasomal pathway" molecular function CBC 24523872 DOK1 A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling "Knockdown of DOK1 and Rap1 inhibited PDGF-BB-induced chemotactic cell migration, and knockdown of DOK1 and Rap1 and expression of DOK1FF inhibited PDGF-mediated three-dimensional (3D) spheroid invasion" molecular function CBC 24762811 DOK1 Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation molecular function CBC 27183638 DOK1 Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer "DOK1 was identified as a prognostic factor for non-metastatic CRC, and, via its drugability by PPAR¦Ã-agonist, may constitute a potential target for future cancer treatments" biomarker CBC 27428427 DOK7 DNA methylation profiling in breast cancer discordant identical twins identifies DOK7 as novel epigenetic biomarker "Hypermethylation of DOK7 occurs years before tumor diagnosis, suggesting a role as a powerful epigenetic blood-based biomarker as well as providing insights into breast cancer pathogenesis." biomarker CBC 23054610 DOK7 The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancer. DOK7 was reduced in lung cancer and reduced DOK7 expression was associated with poorer survival. biomarker CBC 28393246 DOK7 The downstream of tyrosine kinase 7 is reduced in lung cancer and is associated with poor survival of patients with lung cancer. DOK7 isoform 1 plays an inhibitory role on the proliferation and migration of lung cancer cells in which Akt pathway may be involved. molecular function CBC 28393246 DOK7 Evidence for Tumour Suppressor Function of DOK7 in Human Breast Cancer Higher DOK-7 expression was correlated with longer disease free and overall survival times. biomarker CBC DTX3L DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. "Our data strongly indicate that a crosstalk between STAT1, DTX3L and ARTD-like mono-ADP-ribosyltransferases mediates proliferation and survival of metastatic Pca(mPCa) cells." biomarker CBC 24886089 DTX3L DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells. "DTX3L and ARTD9 act together as repressors of the tumor suppressor IRF1 in mPCa cells. Furthermore, the present study shows that DTX3L together with STAT1 and STAT3 is implicated in cell migration of mPCa cells." molecular function CBC 24886089 DTX3L DTX3L is upregulated in glioma and is associated with glioma progression. DTX3L could be a potential prognostic biomarker for glioma. biomarker CBC 28627634 DTX3L DTX3L is upregulated in glioma and is associated with glioma progression. "Knockdown of DTX3L by siRNA transfection increased glioma cell apoptosis. Moreover, suppression of DTX3L expression was shown to significantly inhibit the migration and invasion of glioma cells. " molecular function CBC 28627634 DUSP1 DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine "Gemcitabine-mediated upregulation of DUSP1 contributes to a negative feedback loop that attenuates its beneficial actions on stress pathways and apoptosis, raising the possibility that targeting DUSP1 in PDAC may have the advantage of enhancing gemcitabine chemosensitivity while suppressing angiogenesis" molecular function CBC 24409315 DUSP1 "Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy" "As a protein phosphatase, DUSP1 also downregulates p38?MAPKs and?JNKs signaling through directly dephosphorylating threonine and tyrosine. It has been detected that?DUSP1 is involved in various functions, including proliferation, differentiation, and apoptosis in normal cells. In various human cancers, abnormal expression of?DUSP1 was observed which was associated with prognosis of tumor patients" molecular function CBC 27227569 DUSP1 "DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer" The DUSP1-pERK-MMP2/VEGF signals may provide new biomarkers and/or therapeutic targets to better suppress GBC metastasis in the future molecular function CBC 28129656 DUSP1 DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system DUSP1 may be a promising target to overcome chemoresistance in GBC therapy molecular function CBC 30008878 DUSP1 DUSP1 is involved in the progression of small cell carcinoma of the prostate DUSP1 is involved in the progression of SCCP and may provide a new therapeutic target for SCCP treatment molecular function CBC 30108432 EEF1A1 Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing EEF1A1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) molecular function MFBCE 24255815 EEF1A1 Dissecting the expression of EEF1A1/2 genes in human prostate cancer cells: the potential of EEF1A2 as a hallmark for prostate transformation and progression "Eukaryotic elongation factor 1A2 switch-on, observed in cultured tumour prostate cells and in human prostate tumour samples, may represent a feature of prostate cancer; in contrast, a minor involvement is assigned to EEF1A1" molecular function CBC 22095224 EEF1A1 P21 activated kinase 4 binds translation elongation factor eEF1A1 to promote gastric cancer cell migration and invasion "PAK4 interacted with eEF1A1 to promote migration and invasion of gastric cancer cells, thereby providing new insights into the function of PAK4 and eEF1A1 in the progression of gastric cancer" molecular function CBC 28393218 EEF1A1 Contradictory mRNA and protein misexpression of EEF1A1 in ductal breast carcinoma due to cell cycle regulation and cellular stress "EEF1A1 mRNA levels in breast carcinomas are low due to EEF1A1 allelic copy number loss, found in 27% of tumors, and cell cycle-specific expression, because mRNA levels are high in G1 and low in proliferating cells" molecular function CBC 30224719 EEF1A1 Genome-wide target interactome profiling reveals a novel EEF1A1 epigenetic pathway for oncogenic lncRNA MALAT1 in breast cancer Knockdown of MALAT1 reduced cell proliferation and invasion by arresting cells at the G0/G1 phase. Ectopic overexpression of EEF1A1 reversed the altered tumor phenotypes induced by MALAT1 shRNA treatment molecular function CBC 31105998 EEF1A1 Isoforms of elongation factor eEF1A may be differently regulated at post-transcriptional level in breast cancer progression EEF1A1 and EEF1A2 mRNAs contain distinct motifs in the UTRs and are differently regulated in cancer suggesting the possibility of their control by different cellular signals molecular function CBC ELK1 Estrogen Receptor-mediated Activation of the Serum Response Element in MCF-7 Cells through MAPK-dependent Phosphorylation of Elk-1 Transcriptional activation of the SRE by E2 was due to ER¦Á activation of the MAPK pathway and increased binding of the serum response factor and Elk-1 to the SRE. molecular function CBC 11145955 ELK1 c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells BRCA1a/1b proteins function as growth/tumor suppressors is through inhibition of the expression of Elk-1 target genes like c-Fos molecular function CBC 11313879 ELK1 Genome-Wide Analysis Reveals PADI4 Cooperates with Elk-1 to Activate?c-Fos?Expression in Breast Cancer Cells "PADI4 interacts with Elk-1 at the c-Fos promoter and that, following Epidermal Growth Factor (EGF) stimulation, PADI4 catalytic activity facilitates Elk-1 phosphorylation, histone H4 acetylation, and c-Fos transcriptional activation." molecular function CBC 21655091 ELK1 Tumor-suppressive miRNA-135a inhibits breast cancer cell proliferation by targeting ELK1 and ELK3 oncogenes "MiR-135a regulates cell proliferation in breast cancer by targeting ELK1 and ELK3 oncogenes, and suggests that miR-135a potentially can act as a tumor suppressor" molecular function CBC 29892795 ELK1 Suppression of Elk1 inhibits thyroid cancer progression by mediating PTEN expression "Elk1 inhibition induced thyroid cancer cell apoptosis and restrained their proliferation by regulating Egr-1/PTEN, indicating a potential role for Elk1 in thyroid cancer treatment" molecular function CBC 30015900 ENPP1 Enpp1: A Potential Facilitator of Breast Cancer Bone Metastasis "By both routes of administration, increased expression of Enpp1 enhanced the ability of MDA-MB-231 cells to form tumors in the bone relative to cells expressing vector alone, as determined by digital radiography and histological analysisï¼›these data suggest a potential role for Enpp1 in the development of breast cancer bone metastasis" molecular function CBC 23861746 ENPP1 Identification of Gene Expression Signature in Estrogen Receptor Positive Breast Carcinoma "Significant over-expression of all the six genes in ER¦Á (+) breast tumors as compared to ER¦Á (-) breast tumors. In vitro studies using T-47D breast cancer cell line confirmed the estrogen dependant expression of four of the above six genes (SLC7A8, ENPP1, LAMB2, and PLAT)" molecular function CBC 24179381 ENPP1 Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma "A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state" molecular function CBC 27308351 ENPP1 Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma "A novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state" molecular function CBC 27308351 ENPP1 "Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer" ENPP1 mRNA expression in tissue samples from patients with triple-negative breast cancer was significantly inversely related to recurrence-free survival (RFS) and overall survival (OS) biomarker CBC 31536342 EPCAM Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC Tumour-derived exosomes interfere with the tumour-specific function of immune cells and constitute an additional mechanism how tumours escape from immune surveillance molecular function MFBCE 21293856 EPCAM Epithelial-to-mesenchymal transition induced by TGF-¦Â1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells EpCAM may be an attractive strategy to treat breast cancer.This study implicates the potential value of EpCAM as a molecular marker for breast cancer. biomarker CBC 25205054 EPCAM Epithelial-to-mesenchymal transition induced by TGF-¦Â1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells "EpCAM participated in TGF-¦Â1-induced EMT. TGF-¦Â1 treatment of MCF-7 breast cancer cells was shown to induce EpCAM expression, which promoted the EMT and cell migration. EpCAM overexpression further enhanced TGF-¦Â1-induced EMT and EpCAM knockdown inhibited TGF-¦Â1-induced EMT. We further demonstrated that TGF-¦Â1 treatment induced the phosphorylation of JNK that was in turn responsible for the increased expression of Jun and Fos. This result suggests an important role of the JNK to AP-1 signaling to EpCAM downstream of TGF-¦Â1 for the induction of EMT in the breast cancer cells." molecular function CBC 25205054 EPCAM "By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis" "Overexpression of EpCAM in breast cancer cells enhanced tumor cell growth in vitro and increased invasiveness, whereas small interfering RNA-mediated silencing of EpCAM (si-EpCAM) had the opposite effect. EpCAM knockdown led to decreased phosphorylation of Raf and ERK, suppression of malignant behavior of breast cancer cells, and inhibition of the Ras/Raf/ERK signaling pathway." molecular function CBC 26356670 EPCAM EpCAM and COX?2 expression are positively correlated in human breast cancer EpCAM may serve a role in the regulation of cancer cell growth and may hold potential as a prognostic marker in breast cancer. biomarker CBC 28393249 ERBB2 Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC Tumour-derived exosomes interfere with the tumour-specific function of immune cells and constitute an additional mechanism how tumours escape from immune surveillance molecular function MFBCE 21293856 ERBB2 Genetic alterations in ERBB2-amplified breast carcinomas Breast tumors showing erbB2 overexpression or gene amplification are genetically distinct from erbB2-negative tumors molecular function CBC 10632352 ERBB2 "ERBB2 and TOP2A in Breast Cancer: A Comprehensive Analysis of Gene Amplification, RNA Levels, and Protein Expression and Their Influence on Prognosis and Prediction" "ERBB2 gene expression was associated with the MFI only in estrogen receptor-positive carcinomas, whereas ERBB2 protein expression (P = 0.032) was associated with MFI in the entire cohort" molecular function CBC 20371687 ERBB2 The extracellular domain of Her2 in serum as a biomarker of breast cancer SHER2 ECD should be considered as a promising biomarker to detect cancer recurrence and metastasis biomarker CBC 29491426 ERBB2 Targeting promiscuous heterodimerization overcomes innate resistance to ERBB2 dimerization inhibitors in breast cancer "The interaction of ERBB2 with a number of non-canonical RTKs activates a compensatory signalling response following treatment with pertuzumab, although a counter-intuitive combination of ERBB2 antibody therapy and a kinase inhibitor can overcome this innate therapeutic resistance" molecular function CBC 30898150 FAM162A The usability of a 15-gene hypoxia classifier as a universal hypoxia profile in various cancer cell types "The gene expression analysis demonstrated cell line specific differences in the hypoxia response of the 15 genes, with BNIP3 not being upregulated at hypoxic conditions in 3 out of 6 colon cancer cell lines, and ALDOA in OE21 and FAM162A and SLC2A1 in SW116 only showing limited hypoxia induction" molecular function CBC 26169282 FAM87A Comprehensive analysis of lncRNA-associated competing endogenous RNA network in tongue squamous cell carcinoma " FAM87A was identified as novel, potential prognostic biomarkers and therapeutic targets for tongue squamous cell carcinoma" biomarker CBC 30755833 FAM87A CNV Primed lncRNAs Deregulation Contributes to Poor Prognosis in Colorectal Cancer "Comparing lncRNAs expression patterns between copy-deleted or copy-amplified and the normal samples, we identify 9 lncRNAs(FAM87A, LOC101927752, KBTBD11-OT1, LOC100287015, LOC101929066, CASC11, HM13-AS1, ABALON, NKILA),?" molecular function CBC FGF9 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling "Estrogen or FGF9 pretreatment induced CSC properties of breast cancer cell lines and freshly isolated breast cancer cells, whereas cotreatment of cells with tamoxifen or a small molecule inhibitor of FGFR signaling was sufficient to prevent the estrogen-induced expansion of CSCs" molecular function CBC 21098263 FGF9 Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer FGF9 may be a novel unfavorable prognostic indicator and a candidate therapeutic target of NSCLC molecular function CBC 24239165 FGF9 FGF9 from cancer-associated fibroblasts is a possible mediator of invasion and anti-apoptosis of gastric cancer cells FGF9 is a possible mediator secreted by CAFs that promotes the anti-apoptosis and invasive capability of gastric cancer cells molecular function CBC 25925261 FGF9 The anti-apoptotic and prognostic value of fibroblast growth factor 9 in gastric cancer FGF9 may provide the anti-apoptotic function and be useful as a novel independent marker for evaluating GC prognosis biomarker CBC 27166269 FGF9 "FGF9/FGFR2 increase cell proliferation by activating ERK1/2, Rb/E2F1, and cell cycle pathways in mouse Leydig tumor cells" "FGF9 interacts with FGFR2 to activate ERK1/2, Rb/E2F1 and cell cycle pathways to induce MA-10 cell proliferation in?vitro and tumor growth in vivo" molecular function CBC 30191630 FGFR2 Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential Presumably aid in targeting the primary cancer cells to specific metastatic sites molecular function MFBCE 29115712 FGFR2 The Breast Cancer Susceptibility Gene Product Fibroblast Growth Factor Receptor 2 Serves as a Scaffold for Regulation of NF-¦ÊB Signaling FGFR2 serves as a scaffold for multiple components of the NF-¦ÊB signaling complex molecular function CBC 22988296 FGFR2 Activating somatic FGFR2 mutations in breast cancer Somatic breast cancer mutations in FGFR2 providing evidence for the activating nature of FGFR2-mediated signalling in the pathogenesis of breast cancer molecular function CBC 23527311 FGFR2 Master regulators of FGFR2 signalling and breast cancer risk Fibroblast growth factor receptor 2 signalling has an important role in mediating breast cancer risk molecular function CBC 24043118 FGFR2 FGFR2 amplification in metastatic hormone-positive breast cancer and response to an mTOR inhibitor "GFR2 amplification to treatment with nab-paclitaxel and an mTOR inhibitor, whilst showing no significant benefit from endocrine therapy or treatment with a CDK4/6 inhibitor" molecular function CBC 28430863 FGFR2 FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness FGFR2 can confer increased breast cancer risk that is consistent with oestrogen exposure as a major driver of breast cancer risk molecular function CBC 27236187 FGFR2 Association of FGFR2 and TOX3 Genetic Variants With the Risk of Breast Cancer in Iranian Women Genetic variants of FGFR2 (rs1219648 AG) and TOX3 (rs8051542 TC) can be potential candidate biomarkers for breast cancer risk biomarker CBC FGFR3 Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential Presumably aid in targeting the primary cancer cells to specific metastatic sites molecular function MFBCE 29115712 FGFR3 Frequent activating mutations of FGFR3 in human bladder and cervix carcinomas Genomic alterations of FGFR3 are among the best described oncogenic pathway in UC molecular function CBC 10471491 FGFR3 Immunohistochemical detection of fibroblast growth factor receptor 3 in human breast cancer: correlation with clinicopathological/molecular parameters and prognosis "FGFR3 expression in invasive breast cancer was not found to be significantly associated with specific clinicopathological/molecular parameters, but might be used as a candidate marker for a poor prognosis" biomarker CBC 21116113 FGFR3 Mechanisms of FGFR3 actions in endocrine resistant breast cancer "FGFR3 activation in MCF7 cells stimulated activation of the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) signalling pathways, both of which have been implicated in tamoxifen resistance in breast cancer" molecular function CBC 21792889 FGFR3 FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium Some SNPs in FGFR3 gene were closely related to breast cancer risk biomarker CBC 24548884 FIBP Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential Presumably aid in targeting the primary cancer cells to specific metastatic sites molecular function MFBCE 29115712 FIBP Proteomic Analysis of the Human Cyclin-dependent Kinase Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration "CDK5-, KIAA0528-, or FIBP-depleted breast cancer cells displayed impaired proliferation and decreased migration, suggesting that this complex is required for cell growth and migration in non-neural cells" molecular function CBC 25096995 FIBP "A recessive syndrome of intellectual disability, moderate overgrowth, and renal dysplasia predisposing to Wilms tumor is caused by a mutation in FIBP gene" These findings provide convincing evidence implicating FIBP aberrations in the newly recognized overgrowth syndrome and expand the associated phenotypes to include possible Wilms tumor predisposition molecular function CBC 27183861 FIBP FIBP knockdown attenuates growth and enhances chemotherapy in colorectal cancer via regulating GSK3¦Â-related pathways DNA methylation profiling suggested that FIBP regulated the stemness of CRC cells via methylation activity that was dependent on GSK3¦Â but independent of ¦Â-catenin signaling molecular function CBC 30275459 FRS2 Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential Presumably aid in targeting the primary cancer cells to specific metastatic sites molecular function MFBCE 29115712 FRS2 MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor-positive breast cancer patients receiving tamoxifen as an adjuvant endocrine therapy biomarker CBC 27533459 FRS2 MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy "Fibroblast growth factor receptor substrate 2 (FRS2, also known as FRS2alpha) is a member of the adaptor/scaffold protein family. It was considered as an essential-conning center in FGFR signaling . FSR2 binds through its N-terminal phosphotyrosine-binding domain (PTB) to FGFR, resulting in phosphorylation of multiple tyrosine residues of FRS2 and subsequent activation of the downstream signaling (e.g., RAS/MAPK/ERK, PI3K/AKT/mTOR) and ubiquitination/degradation pathways . FRS2 acts as an oncogene in a variety of cancers, which regulates tumor cell differentiation, proliferation, and tumorigenesis . Inhibition of FRS2 could block the FGFR signaling and downstream biological functions" molecular function CBC 27533459 FRS2 Targeting FGFR pathway in breast cancer "Activated FRS2 promotes downstream signaling through the RAS-mitogen-activated protein kinase (MAPK) or the phosphoinositide 3-kinase (PI3K)-AKT pathways that regulate cell proliferation, differentiation, and survival" molecular function CBC 29156384 FTH1 Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) molecular function MFBCE 24255815 FTH1 Ferritin binds and activates p53 under oxidative stress Our findings show that ferroxidase activity is not required for FTH1 to increase p53 transcriptional activity molecular function CBC 19716362 FTH1 Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response "Our data provide evidence toward new immune regulatory properties of FTH1 in TNBC, which may facilitate development of novel therapeutic targets" molecular function CBC 24742827 FTH1 Regulation of iron homeostasis by the p53-ISCU pathway "In response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells. HCT116 p53+/+ cells were resistant to iron accumulation, but HCT116 p53 / cells accumulated intracellular iron after DNA damage" molecular function CBC 26560363 FTH1 Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells Real time quantitative polymerase chain reaction showed that iron up-regulated the expression of FTH1 and iron chelator DFOM reduced FTH1 expression of MCF-7 and MDA-MB-231 cells molecular function CBC 28476795 FTH1 A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer "?In this study, we utilize an unbiased screen to identify the ferritin heavy chain 1 (FTH1) transcript and multiple FTH1 pseudogenes as targets of several oncogenic miRNAs in prostate cancer (PCa). We characterize the critical role of this FTH1 gene:pseudogene:miRNA network in regulating tumorigenesis in PCa, whereby oncogenic miRNAs downregulate the expression of FTH1 and its pseudogenes to drive oncogenesis" molecular function CBC 29240947 FTL Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing FTL distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) molecular function MFBCE 24255815 FTL Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study "The validation of FTL as a breast tumor prognostic biomarker in node-negative patients, and second, the fact that FTL is stored in TAM" biomarker CBC 21898387 FTL Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin The increased levels of FTL in breast cancer indicate that FTL may be used as a diagnostic and prognostic marker for breast cancer biomarker CBC 23969999 FTL Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin Targeted downregulation of FTL protein by the microRNA miR-133a increases sensitivity of MCF-7/DOX and MCF-7/CDDP cells to doxorubicin and cisplatin molecular function CBC 23969999 FTL Ferritin Heavy Chain in Triple Negative Breast Cancer: A Favorable Prognostic Marker that Relates to a Cluster of Differentiation 8 Positive (CD8+) Effector T-cell Response "We observed that protein expression of FTH1 was significantly higher in good prognostic patients (n = 82) than those with poor prognosis (n = 44) (p = 0.001), whereas neither expression of FTL (p = 0.054) nor FTH1/FTL ratio (p = 0.566) showed significant difference between patients with different clinical outcome" biomarker CBC 24742827 FTL "Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway" FTL regulates the growth of GBM cells via the GADD45/JNK pathway molecular function CBC 26871431 FZD5 Expression and regulation of WNT5A and WNT5B in human cancer: Up-regulation of WNT5A by TNF¦Á in MKN45 cells and up-regulation of WNT5B by ¦Â-estradiol in MCF-7 cells Up-regulation of WNT5A and WNT5B in several types of human cancer expressing FZD5 might lead to more malignant phenotype through activation of the ¦Â-catenin - TCF pathway molecular function CBC 12165812 FZD5 Microrna-224 inhibits proliferation and migration of breast cancer cells by down-regulating fizzled 5 expression MiR-224 inhibited cell proliferation and migration by targeting FZD5 and inhibiting WNT/¦Â-catenin signaling in breast cancer molecular function CBC 27323393 FZD5 "MicroRNA-671-3p inhibits the development of breast cancer: A study based on in vitro experiments, in-house quantitative polymerase chain reaction and bioinformatics analysis" "WNT3A, CCND2, SFRP1, PRICKLE2, FZD5 and FZD4 were markedly downregulated in BC, suggesting that they may function as tumor suppressor genes in this tumor" molecular function CBC 29620195 FZD5 Role of WNT5A receptors FZD5 and RYK in prostate cancer cells WNT5A/FZD5 and WNT5A/RYK signaling are both involved in mediating the pro-apoptotic and anti-proliferative effects of WNT5A in prostate cancer molecular function CBC 29930766 GATA4 A Negative Feedback Regulatory Loop Associates the Tyrosine Kinase Receptor ERBB2 and the Transcription Factor GATA4 in Breast Cancer Cells "In agreement with a repressor role of GATA4 on ERBB2 gene expression balanced by ERBB2 activation of the GATA4 gene, a negative correlation between the relative levels of ERBB2 and GATA4 mRNA was observed in breast cancer cell lines and breast tumor samples" molecular function CBC 19276186 GATA4 GATA4 promotes hepatoblastoma cell proliferation by altering expression of miR125b and DKK3 GATA4 is therefore a potential therapeutic target or biomarker for progression in HB patients biomarker CBC 27788486 GATA4 GATA4 promotes hepatoblastoma cell proliferation by altering expression of miR125b and DKK3 "GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells" molecular function CBC 27788486 GATA4 GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition "Thus, disruption of GATA4-mediated transactivation in HCC suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype" molecular function CBC 28758902 GATA4 GATA4 inhibits cell differentiation and proliferation in pancreatic cancer GATA4 gene might play a role in cell proliferation and differentiation during the progression of pancreatic cancer molecular function CBC 30142155 GATA4 Restoration of GATA4 expression impedes breast cancer progression by transcriptional repression of ReLA and inhibition of NF-¦ÊB signaling GATA4 is a potential prognostic biomarker and gene therapeutic target for human BrCa biomarker CBC 30187949 GATA4 Restoration of GATA4 expression impedes breast cancer progression by transcriptional repression of ReLA and inhibition of NF-¦ÊB signaling GATA4 plays a tumor-suppressive role via repression of NF-¦ÊB signaling in BrCa cells molecular function CBC 30187949 GATA4 GATA4 is upregulated in nasopharyngeal cancer and facilitates epithelial-mesenchymal transition and metastasis through regulation of?SLUG GATA4 acts as an oncogene and serves crucial roles in NPC and GATA4 may find a potential application as therapeutic option in NPC molecular function CBC 30542490 GPBAR1 Deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis "TGR5 antagonizes the STAT3 pathway through suppressing STAT3 phosphorylation, its transcription activity, and DNA binding activity, which suggests that TGR5 antagonizes liver tumorigenesis at least in part by inhibiting STAT3 signaling" molecular function CBC 22911633 GPBAR1 Pancreatic acinar cell nuclear factor ¦ÊB activation because of bile acid exposure is dependent on calcineurin Acinar cell exposure to bile acids and activation of Gpbar1 cause cell injury mediated by Ca2+?signaling and downstream NF-¦ÊB translocation molecular function CBC 23744075 GPBAR1 TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro "TGR5 is an important mediator of BA-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis" molecular function CBC 26420419 GPBAR1 Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia TGR5 functions as a tumor-suppressor in patients with ampullary adenocarcinoma and preoperative hyperbilirubinemia molecular function CBC 27510297 GPBAR1 The deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis "TGR5 antagonizes STAT3 pathway through suppressing STAT3 phosphorylation, its transcription activity and DNA binding activity, which suggests that TGR5 antagonizes liver tumorigenesis at least in part by inhibiting STAT3 signaling" molecular function CBC 22911633 GSTP1 Predictive role of GSTP1-containing exosomes in chemotherapy-resistant breast cancer Affecting drug metabolism---Anthracycline/taxane-based neoadjuvant chemotherapy molecular function MFBCE 28438694 GSTP1 "Cruciferous vegetables, the GSTP1 Ile105Val genetic polymorphism, and breast cancer risk" Cruciferous vegetable intake consistent with high isothiocyanate exposure may reduce breast cancer risk. Cruciferous vegetable intake also may ameliorate the effects of the GSTP1 genotype molecular function CBC 18326615 GSTP1 GSTP1 methylation and polymorphism increase the risk of breast cancer and the effects of diet and lifestyle in breast cancer patients GSTP1 methylation is a major event in breast carcinogenesis and may act as a tumor-specific biomarker biomarker CBC 23226781 GSTP1 The GSTP1 105Val Allele Increases Breast Cancer Risk and Aggressiveness but Enhances Response to Cyclophosphamide Chemotherapy in North China GSTP1 Ile105Val genotype may help screen for high-risk populations and direct individualized therapy molecular function CBC 23826324 GSTP1 Association of GSTP1 Methylation with Aggressive Phenotype in ER-positive Breast Cancer GSTP1 methylation may well be associated with the pathogenesis of the biologically-aggressive phenotype in ER-positive breast cancer molecular function CBC 24324107 GSTP1 GSTP1 Is a Driver of Triple-Negative Breast Cancer Cell Metabolism and Pathogenicity GSTP1 inhibitors as a novel therapeutic strategy for combatting TNBCs through impairing key cancer metabolism and signaling pathways molecular function CBC 27185638 GSTP1 Prognostic significance of GSTP1 in patients with triple negative breast cancer GSTP1 protein may be a novel prognosis marker for TNBC patients in China biomarker CBC 28978147 GSTP1 CLDN6 promotes chemoresistance through GSTP1 in human breast cancer "High expression of CLDN6 confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53" molecular function CBC 29116019 GTF2I A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors "GTF2I mutation correlated with better survival. GTF2I ¦Â and ¦Ä isoforms were expressed in TETs, and both mutant isoforms were able to stimulate cell proliferation in vitro" molecular function CBC 24974848 GTF2I GTF2I mutation frequently occurs in more indolent thymic epithelial tumors and predicts better prognosis "The frequency of the GTF2I mutation is higher in more indolent TETs, and correlates with better prognosis. " molecular function CBC 28676218 GTF2I GTF2I Mutations Are Common in Thymic Epithelial Tumors But Not in Hematological Malignancies GTF2I mutation is not present or is uncommon in these diseases molecular function CBC 28982856 GTF2I The Integrated Genomic Landscape of Thymic Epithelial Tumors The Integrated Genomic Landscape of Thymic Epithelial Tumors molecular function CBC 29438696 GTF2I Comprehensive epigenetic analyses reveal master regulators driving lung metastasis of breast cancer "TFAP2C, GTF2I and LMO4 were found to have potential prognostic value for lung metastasis free (LMF) survival of breast cance" biomarker CBC 31215771 HDC Histamine synthesis and content in benign and malignant breast tumours. Its effects on other host tissues "The HDC-activity of cancerous tissue was significantly higher (P < 0.01) than that registered in the healthy mammary gland tissue of the same patient, being even more pronounced in benign tumour tissue (P < 0.001)" molecular function CBC 7952401 HDC Concentration of histamine in serum and tissues of the primary ductal breast cancers in women "The activity of HDC was significantly higher in cancerous tissues than in adjacent healthy tissues (54.7+/-17.1 vs. 34.5+/-24.3 pmol/min per mg; P<0.001), but there was no difference in the activity of DAO (14.0+/-6.4 vs. 14.4+/-10.9 pmol/min per mg)" molecular function CBC 15927833 HDC The Role of Cyclooxygenase-2 in Mediating the Effects of Histamine on Cell Proliferation and Vascular Endothelial Growth Factor Production in Colorectal Cancer Histidine decarboxylase activity and histamine content were also significantly higher in metastatic tumors than in nonmetastatic ones molecular function CBC 16203768 HDC Metabolism of histamine in tissues of primary ductal breast cancer "A significant increase in the concentration of histamine in plasma (P < .01) and tissues of ductal breast cancers (P < .001), and in the activity of histidine decarboxylase (P < .01), aromatic L-amino acids (P < .05), and histamine methyltransferase (P < .05) was found" molecular function CBC 19375125 HDC "Associations of polymorphisms in histidine decarboxylase, histamine N-methyltransferase and histamine receptor H3 genes with breast cancer" Polymorphisms of HDC gene were significantly associated with breast cancer in Chinese Han population and may be novel diagnostic or therapeutic targets for breast cancer biomarker CBC 24835231 HER2 Clinical application of a microfluidic chip for immunocapture and quantification of circulating exosomes to assist breast cancer diagnosis and molecular classification The exosomal HER2 expression levels were almost consistent with that in tumor tissues assessed by immunohistochemical staining molecular function MFBCE 28369094 HER2 "The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy" Human epidermal growth factor receptor 2 (HER2) is overexpressed in around 20-30% of breast cancer tumors molecular function CBC 23320171 HER2 HER2-targeted therapies -a role beyond breast cancer "HER2 is an established therapeutic target in a large subset of women with breast cancer; a variety of agents including trastuzumab, pertuzumab, lapatinib, neratinib and trastuzumab emtansine (T-DM1) have been approved for the treatment of HER2-positive breast cancer" molecular function CBC 30922362 HER2 Activating HER2 mutations in HER2 gene amplification negative breast cancer The majority of HER2 somatic mutations in breast cancer patients are activating mutations that likely drive tumorigenesis molecular function CBC 23220880 HER2 HER2 and responsiveness of breast cancer to adjuvant chemotherapy Amplification of HER2 in breast-cancer cells is associated with clinical responsiveness to anthracycline-containing chemotherapy molecular function CBC 16707747 HER2 Intratumoral heterogeneity of HER2 gene amplification in breast cancer: its clinicopathological significance "Intratumoral heterogeneity of HER2 gene amplification is present in a subset of HER2-amplified breast cancers, especially in cases with low-grade HER2 amplification and equivocal HER2 expression, indicating a need for HER2 testing on more representative, larger tumor samples for accurate assessment of HER2 status in such cases" molecular function CBC 22388760 HER2 HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells HER2-mediated prosurvival signaling network is responsible for the aggressive phenotype of BCSCs that could be targeted to control the therapy-resistant HER2(-/low) breast cancer molecular function CBC 23091114 HER2 HER2 and TOP2A as predictive markers for anthracycline-containing chemotherapy regimens as adjuvant treatment of breast cancer: a meta-analysis of individual patient data. "Although HER2 amplification and combined TOP2A amplification and deletion may have some value in the prediction of responsiveness to anthracycline-based chemotherapy, our findings do not support the use of anthracyclines only in patients with HER2-amplified or TOP2A-aberrated tumours" molecular function CBC 21917518 HEXA Hypermethylation contributes to down-regulation of lysosomal ¦Â-hexosaminidase ¦Á subunit in prostate cancer cells "The HEXA promoter region in LNCaP and PC3 cell lines had methylated CpG islands, as confirmed by 5'-Aza-2'-deoxycitidine treatment, in PC3 cells, used as cell cancer model" molecular function CBC 24389457 HLA-DQA1 "Contribution of the TP53, OGG1, CHRNA3, and HLA-DQA1 genes to the risk for lung squamous cell carcinoma" "Genotypes for two DNA repair genes, TP53 and OGG1, showed significant associations with SQC risk (p < 0.05), and those for two GWAS genes, CHRNA3 and HLA-DQA1, showed significant associations with SQC risk (P < 0.05) with odds ratios between 1.65 (95% confidence interval = 1.06-2.57 for OGG1) and 2.57 (95% confidence interval = 1.03-6.87 for CHRNA3)" molecular function CBC 21623257 HLA-DQA1 "HLA-DRB1,-DQA1 and -DQB1 allele and haplotype frequencies in female patients with early onset breast cancer" HLA-DQA1*0301 allele is mainly associated with increased risk of breast cancer including early-onset of the disease. HLA-DQA1*0505 and HLA-DRB1*1301 are involved in protection. We conclude that specific alleles of HLA class II influence breast cancer risk molecular function CBC 21720852 HLA-DQA1 "Association between HLA-DQA1, HLA-DQB1 and oral cancer" Both HLA-DQA1* and HLA-DQB1* allele frequencies in oral cancer patients revealed no significant difference from those of control groups molecular function CBC 21943816 HLA-DQA1 "HLA-DQA1 & DQB1 variants associated with hepatitis B virus-related chronic hepatitis, cirrhosis & hepatocellular carcinoma" Our results revealed HLA-DQA1*0101/2/4 - DQA1*0103 - DQB1*0302/3 and DQB1*0601 as protective and DQB1*0402 as risk alleles. The study suggests that various subtypes of HLA-DQA1 and DQB1 are associated with both HBV clearance and development of chronic HBV infections molecular function CBC 30168489 HLA-DQA1 High expression of HLA-DQA1 predicts poor outcome in patients with esophageal squamous cell carcinoma in Northern China "HLA-DQA1 plays an important role in ESCC progression and may be a biomarker for ESCC diagnosis and prognosis, as well as a potential target for the treatment of patients with ESCC" molecular function CBC 30813145 HOXC6 Exosomes enriched in stemness/metastatic-related mRNAS promote oncogenic potential in breast cancer "Stemness markers and enhance proliferation,migration and invasion abilities of neighboring cells" molecular function MFBCE 26528758 HOXC6 "Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer" " HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA, in vitro and in vivo" molecular function CBC 25725483 HOXC6 The role of HOXC6 in prostate cancer development HOXC6 is a novel candidate biomarker for PCa not only in early detection but also for monitoring of progression or response to therapy biomarker CBC 26310814 HOXC6 "Identification of activated enhancers and linked transcription factors in breast, prostate, and kidney tumors by tracing enhancer networks using epigenetic traits" HOXC6 and DLX1 are associated with different clusters of prostate tumor-specific enhancers and confer distinct transcriptomic changes upon knockdown in C42B prostate cancer cells molecular function CBC 27833659 HOXC6 Long noncoding RNA Linc00339 promotes triple-negative breast cancer progression through miR-77-p/HOXC6 signaling pathway Linc00339/miR-377-3p/HOXC6 axis played a critical role in TNBC progression and might be a promising therapeutic target for TNBC treatment molecular function CBC 30618083 HOXC6 Overexpression of HOXC6 promotes cell proliferation and migration via MAPK signaling and predicts a poor prognosis in glioblastoma HOXC6 promoted proliferation and migration of GBM cells via the activation of MAPK pathway molecular function CBC 31564976 HRNR Hornerin promotes tumor progression and is associated with poor prognosis in hepatocellular carcinoma HRNR promotes tumor progression and is correlated with a poor HCC prognosis. HRNR may contribute to HCC progression via the regulation of the AKT pathway. biomarker CBC 30103712 HRNR Hornerin promotes tumor progression and is associated with poor prognosis in hepatocellular carcinoma "The knockdown of HRNR by shRNAs significantly inhibited the proliferation, colony formation, migration and invasion of HCC tumor cells. HRNR silencing led to the decreased phosphorylation of AKT signaling." molecular function CBC 30103712 hsa-let-7a Plasma exosome microRNAs are indicative of breast cancer "Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer" biomarker BBCE 27608715 hsa-let-7a MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7 "Targeting of CCL21-CCR7 signaling is a valid approach for breast cancer therapy and that let-7a directly binds to the 3'UTR of CCR7 and blocks its protein expression, thereby suppressing migration and invasion of human breast cancer cells" molecular function CBC 22251626 hsa-let-7a Let-7a inhibits growth and migration of breast cancer cells by targeting HMGA1 "Let-7a plays an important role as a tumor suppressor gene by targeting HMGA1, which may open novel perspectives for clinical treatments against breast cancer" molecular function CBC 25846193 hsa-let-7a Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer MiR-195 and let-7a can be used as a non-invasive biomarker for breast cancer detection biomarker CBC 29995098 hsa-let-7a Role of let-7 family microRNA in breast cancer This article will provide the in-depth insight into the biology of let-7 miRNA and its role in the breast cancer progression molecular function CBC 30159414 hsa-let-7a "Plasma miR-21, miR-155, miR-10b, and Let-7a as the potential biomarkers for the monitoring of breast cancer patient" Hsa-let-7a might be considered as a respectable diagnostic tool for monitoring of breast cancer patients biomarker CBC 30568292 hsa-let-7a Robust expression of tumor suppressor miRNA- let-7 and miR-195 detected in plasma of Saudi female breast cancer patients "In order to facilitate earlier detection of breast cancer, blood based screening of hsa-miR-195 and let-7 may be beneficial in a female patient cohort" molecular function CBC 29183284 hsa-miR-100 Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs "Target gene prediction and pathway analysis showed the involvement of miR-100, miR-222, and miR-30a in pathways implicated in cancer pathogenesis, membrane vesiculation and therapy failure.The transmition of chemoresistance by a horizontal transfer of miRNAs" molecular function MFBCE 24740415 hsa-miR-100 EphB6 receptor modulates micro RNA profile of breast carcinoma cells MiR-100 and EphB6 involve in PI3K/Akt/mTOR pathways which is capable of initiating signal transduction from the cell surface to the nucleus resulting in the altered expression of a variety of genes involved in tumorigenesis and invasion molecular function CBC 21811619 hsa-miR-100 miR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling MiR-100 as a context-dependent master regulator of the IGF/mTOR pathway and a potential target for therapeutic approaches molecular function CBC 22926517 hsa-miR-100 "By promoting cell differentiation, miR-100 sensitizes basal-like breast cancer stem cells to hormonal therapy" MiR-100 is a negative prognostic factor and is associated with gene signatures of high grade undifferentiated tumors biomarker CBC 25537513 hsa-miR-100 The role of miR-100 in regulating apoptosis of breast cancer cells "Antagonism of miR-100 in SK-BR-3 cells increased the expression of MTMR3, a target gene of miR-100, which resulted in the activation of p27 and eventually led to G2/M cell-cycle arrest and apoptosi" molecular function CBC 26130569 hsa-miR-101 Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients "In conclusion, our findings suggest cell-free miR-101 and miR-373 as breast cancer-specific markers" biomarker BBCE 25333260 hsa-miR-101 miR-101 promotes breast cancer cell apoptosis by targeting Janus kinase 2 MiR-101 suppressed proliferation and promoted apoptosis in breast cancer cells by targeting Jak2. These findings indicate that manipulation of miR-101 expression may represent a novel therapeutic strategy in the treatment of breast cancer molecular function CBC 25059472 hsa-miR-101 MiRNA-101 inhibits breast cancer growth and metastasis by targeting CX chemokine receptor 7 STAT3 signaling downstream of CXCR7 is involved in miR-101 regulation of breast cancer cell behaviors. These findings have implications for the potential application of miR-101 in breast cancer treatment molecular function CBC 26360780 hsa-miR-101 "MicroRNA-101 Inhibits Growth, Proliferation and Migration and Induces Apoptosis of Breast Cancer Cells by Targeting Sex-Determining Region Y-Box 2" "SOX2 knockdown mimicked the effects of miR-101 overexpression on the malignant behaviors of BC cells, while SOX2 overexpression mitigated the miR-101-induced inhibition of these effects;miR-101 plays a critical role in suppressing tumor progression by directly targeting SOX2" molecular function CBC 28946143 hsa-miR-101 "MiR-101 may be a novel marker for diagnosis and prognosis in breast cancer, which might improve the clinical outcomes of patients with breast cancer" MicroRNA-101 is a novel biomarker for diagnosis and prognosis in breast cancer biomarker CBC hsa-miR-103 Blood Circulating Exosomes Contain Distinguishable Fractions of Free and Cell-Surface-Associated Vesicles "Preliminary data indicated that detection of cancer-specific miRNA (miR-103, miR-191, miR-195) in exosomes associated with the fraction of red blood cells allowed to discriminate HFs and BCPs more precisely compared to cell-free exosomes circulating in plasma" biomarker BBCE 30868953 hsa-miR-103 A MicroRNA targeting dicer for metastasis control "In human primary breast tumors, miR-103/107, but not Dicer mRNA, as prognostic marker. miR-103/107 with a better patient stratification capacity than Dicer transcripts." biomarker CBC 20603000 hsa-miR-103 A MicroRNA targeting dicer for metastasis control "In metastatic cells, high levels of miR-103/107 attenuate Dicer expression: this empowers invasive and metastatic properties without major impact on primary tumor growth.At the cellular level, a key event fostered by miR-103/107 is induction of epithelial-to-mesenchymal transition (EMT), attained by downregulating miR-200 levels." molecular function CBC 20603000 hsa-miR-103 Upregulation of serum miR-103 predicts unfavorable prognosis in patients with colorectal cancer. "Serum miR-103 was significantly correlated with worse clinical factors, as well as poorer recurrence-free survival or overall survival. Finally, multivariate analysis confirmed that serum miR-103 was an independent prognostic marker for CRC." biomarker CBC 30058684 hsa-miR-105 Cancer-secreted hsa-miR-105 destroys vascular endothelial barriers to promote metastasis Hsa-miR-105 has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 24735924 hsa-miR-105 Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy "Higher levels of exosomal miRNA-21, miRNA-222, and miRNA-155 were significantly associated with the presence of circulating tumor cells;Liquid biopsies based on exosomal miRNAs and circulating tumor cells can be a complementary clinical tool for improving breast cancer diagnosis and prognosis" biomarker BBCE 30728048 hsa-miR-105 Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis "MiR-105 can be detected in the circulation at the pre-metastatic stage, and its levels in the blood and tumor are associated with ZO-1 expression and metastatic progression in early-stage breast cancer" molecular function CBC 24735924 hsa-miR-105 miR-105/93-3p promotes chemoresistance and circulating miR-105/93-3p acts as a diagnostic biomarker for triple negative breast cancer MiR-105/93-3p levels represent a prime candidate for development into a diagnostic biomarker for both early- and late-stage TNBC biomarker CBC 29258605 hsa-miR-105 Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells MiR-105-mediated metabolic reprogramming of stromal cells contributes to sustained tumour growth by conditioning the shared metabolic environment molecular function CBC 29662176 hsa-miR-105 miR-195/miR-497 Regulate CD274 Expression of Immune Regulatory Ligands in Triple-Negative Breast Cancer "MiR-105, and miR-340 expression levels were associated with a poor prognosis in patients with breast cancer" biomarker CBC 30607158 hsa-miR-105 The Diverse Oncogenic and Tumor Suppressor Roles of microRNA-105 in Cancer This review may provide new ideas for applying miR-105 as a diagnostic and prognostic biomarker biomarker CBC 31281797 hsa-miR-105 The Diverse Oncogenic and Tumor Suppressor Roles of microRNA-105 in Cancer We emphasize the characteristics of miR-105 in cancer to elucidate various deadly tumors and discuss transcriptional regulations that may explain fluctuations in miR-105 expression molecular function CBC 31281797 hsa-miR-106b Molecular characterization of exosome-like vesicles from breast cancer cells "The mir-106b is found in higher levels in MCF-Eox as well, which can promote breast cancer invasion and metastasis by targeting BRMS1 and RB" molecular function MFBCE 24468161 hsa-miR-106b "The miR-106b-25 cluster targets Smad7, activates TGF-¦Â signaling, and induces EMT and tumor initiating cell characteristics downstream of Six1 in human breast cancer" "MiR-106b-25 may provide a novel molecular explanation, through the Six1 regulated miR-106b-25 cluster, by which TGF-¦Â signaling shifts from tumor suppressive to tumor promoting" molecular function CBC 22286770 hsa-miR-106b Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2 "MMP2 upregulation plays an important role in BC bone metastasis through ERK pathways, and miR-106b directly regulates MMP2 expression" molecular function CBC 24164962 hsa-miR-106b Prognostic value of miR-106b expression in breast cancer patients "MiR-106b was found to be associated with a high risk of recurrence of breast cancer, and miR-106b is a putative plasma marker for risk assessment in patients with breast cancer" biomarker CBC 25619461 hsa-miR-10a Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Hsa-miR-10a has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 25446899 hsa-miR-10a Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment MiR-126 and miR-10a are independent predictors for tumour relapse in early postmenopausal breast cancer patients treated with adjuvant tamoxifen. biomarker CBC 23968733 hsa-miR-10a The prognostic significance of RUNX2 and miR-10a/10b and their inter-relationship in breast cancer Higher expression of RUNX2 and miR-10a/b was associated with adverse outcome of breast cancer. Expression levels of RUNX2 and miR-10a/b individually or jointly are potential prognostic factors for predicting breast cancer recurrence. biomarker CBC 25266482 hsa-miR-10a miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis "Higher miR-10a levels are significantly correlated with less aggressive CRC phenotypes in patients, which may have prognostic and therapeutic value for CRC patients in the future." biomarker CBC 28383561 hsa-miR-10a miR-10a suppresses colorectal cancer metastasis by modulating the epithelial-to-mesenchymal transition and anoikis "MiR-10a promoted migration and invasion in vitro but inhibited metastasis in vivo by regulating the epithelial-to-mesenchymal transition and anoikis.Furthermore, matrix metalloproteinase 14 (MMP14) and actin gamma 1 (ACTG1) were validated as target genes of miR-10a in CRC cells.Ectopic expression of MMP14 and ACTG1 counteracted the decreased cell adhesion and anoikis resistance activities induced by miR-10a." molecular function CBC 28383561 hsa-miR-10b Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Hsa-miR-10b has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 25446899 hsa-miR-10b Exosome-mediated transfer of hsa-miR-10b promotes cell invasion in breast cancer Hsa-miR-10b secretes protein levels that inhibit its target genes such as HOXD10 and KLF4 and induces invasion of breast cancer cells molecular function MFBCE 25428807 hsa-miR-10b Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. MicroRNA-10b (miR-10b) is highly expressed in metastatic breast cancer cells and positively regulates cell migration and invasion.Overexpression of miR-10b in otherwise non-metastatic breast tumours initiates robust invasion and metastasis. The level of miR-10b expression in primary breast carcinomas correlates with clinical progression. biomarker CBC 17898713 hsa-miR-10b Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. "Expression of miR-10b is induced by the transcription factor Twist, which binds directly to the putative promoter of mir-10b (MIRN10B). The miR-10b induced by Twist proceeds to inhibit translation of the messenger RNA encoding homeobox D10, resulting in increased expression of a well-characterized pro-metastatic gene, RHOC." molecular function CBC 17898713 hsa-miR-10b "MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC." MiR-10b might play some role in the invasion of glioma cells. biomarker CBC 19536818 hsa-miR-10b "MicroRNA-10b is overexpressed in malignant glioma and associated with tumor invasive factors, uPAR and RhoC." "MiR-10b expression pattern in glioma. miR-10b inhibits the translation of mRNA encoding HOXD10, which modulates many genes that promote invasion, migration, extracellular matrix remodeling and tumor progression, including uPAR, RhoC, ¦Á3 integrin, ¦Â integrin and matrix metalloprotease-4 (MMP-4)." molecular function CBC 19536818 hsa-miR-10b The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers. Circulating miRNA-10b and miRNA-373 are potential biomarkers for detecting the lymph node status of breast cancer. biomarker CBC 23238818 hsa-miR-1207-5p miR-1207-5p and miR-1266 suppress gastric cancer growth and invasion by targeting telomerase reverse transcriptase "MiR-1207-5p and miR-1266 were determined to be hTERT suppressors in gastric cancer, and the delivery of these two miRNAs represents a novel therapeutic strategy for gastric cancer treatment" molecular function CBC 24481448 hsa-miR-1207-5p miR-1207-5p suppresses lung cancer growth and metastasis by targeting CSF1 MiR-1207-5p-CSF1 axis maybe a new regulator of lung cancer development through modulating the tumor microenvironment molecular function CBC 27107415 hsa-miR-1207-5p PVT1-derived miR-1207-5p promotes breast cancer cell growth by targeting STAT6 "PVT1-derived miR-1207-5p promotes the proliferation of breast cancer cells by targeting STAT6, which in turn controls CDKN1A and CDKN1B expression;miR-1207-5p might be a potential target for breast cancer therapy" molecular function CBC 28235236 hsa-miR-1207-5p miR-1207-5p regulates the sensitivity of triple-negative breast cancer cells to Taxol treatment via the suppression of LZTS1 expression There was a notable elevation in the expression of miR-1207-5p and a reduction in the expression of LZTS1 in the Taxol non-responsive TNBC tissues when compared with the Taxol-responsive TNBC tissues molecular function CBC 30655858 hsa-miR-1207-5p MicroRNA miR-1207-5p-repression of ATRA receptors determine retinoid-resistance in breast cancer MiR-1207-5p in the regulation of retinoid-resistance in the BLBC cells and reflects on potential use of a combination of miR-1207-5p antagonists (antagomir and sponges) and ATRA as potent chemotherapy against hard-to-cure BLBC molecular function CBC hsa-miR-122 Breast-cancer-secreted hsa-miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis Hsa-miR-122 suppresses glucose uptake by downregulating the glycolytic enzyme pyruvate kinase (PKM)to promote metastasis molecular function MFBCE 25621950 hsa-miR-122 Plasma exosome microRNAs are indicative of breast cancer "Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer" biomarker BBCE 27608715 hsa-miR-122 De novo sequencing of circulating miRNAs identifies novel markers predicting clinical outcome of locally advanced breast cancer "Certain miRNAs can serve as potential blood-based biomarkers for NCT response, and that miR-122 prevalence in the circulation predicts BC metastasis in early-stage patients" biomarker CBC 22400902 hsa-miR-122 MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R MiR-122 may serve as a novel therapeutic or diagnostic/prognostic-target for treating BC biomarker CBC 23056576 hsa-miR-122 MiR-122 inhibits cell proliferation and tumorigenesis of breast cancer by targeting IGF1R MiR-122 functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting IGF1R and regulating PI3K/Akt/mTOR/p70S6K pathway molecular function CBC 23056576 hsa-miR-122 Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis "By modifying glucose utilization by recipient premetastatic niche cells, cancer-derived extracellular miR-122 is able to reprogram systemic energy metabolism to facilitate disease progression" biomarker CBC 25621950 hsa-miR-122 Evaluation of miR-122 as a Serum Biomarker for Hepatotoxicity in Investigative Rat Toxicology Studies "Serum miR-122 levels can be utilized as a biomarker of hepatotoxicity in acute and subacute rat toxicology studies, and its performance can rival or exceed those of standard enzyme biomarkers such as the liver transaminases" biomarker CBC 26123229 hsa-miR-122 Inhibition of breast cancer cell proliferation and tumorigenesis by long non-coding RNA RPPH1 down-regulation of miR-122 expression Breast cancer progression can be promoted by directly targeting miR-122 through lncRNA RPPH1 molecular function CBC 29200969 hsa-miR-1228-5p A Serum MicroRNA Panel as Potential Biomarkers for Hepatocellular Carcinoma Related with Hepatitis B Virus "Tan and colleagues identified a serum of miRNA panel (hsa-miR-206, hsa-miR-141-3p, hsa-miR-433-3p, hsa-miR-1228-5p, hsa-miR-199a-5p, hsa-miR-122-5p, hsa-miR-192-5p, and hsa-miR-26a-5p) that has considerable clinical value in HCC diagnosis" biomarker CBC 25238238 hsa-miR-1233-5p Significance of microRNA-based biomarkers for pancreatic cancer "Fifteen miRNAs (miR-106b-3p, miR-1233*, miR-1271-5p, miR-1285-3p, miR-15b-3p*, miR-181c-5p, miR-26b-3p, miR-30d-3p, miR-335-3p*, miR-454-5p*, miR-589-3p, miR-616-3p, miR-663b, miR-664-3p, and miR-744-3p) were significantly dysregulated in patients with PC compared to HC on normalization to both U6 and miR-16" molecular function CBC 26605323 hsa-miR-124-3p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-124-3p Decreased miR-124-3p Expression Prompted Breast Cancer Cell Progression Mainly by Targeting Beclin-1 "Decreased miR-124-3p expression prompted breast cancer cell progression mainly by enhancing the expression of autophagy related protein, Beclin-1" molecular function CBC 27468577 hsa-miR-124-3p miR-124-3p functions as a tumor suppressor in breast cancer by targeting CBL MiR-124-3p and CBL regulate the proliferation and invasion of breast cancer cells molecular function CBC 27842510 hsa-miR-124-3p miR-124-3p acts as a potential marker and suppresses tumor growth in gastric cancer The underlying mechanism for the regulation of gastric cancer by miR-124-3p via targeting of Rac1 and SP1 molecular function CBC 30013778 hsa-miR-124-3p miR-124-3p could be used as biomarkers for HNSCC diagnosis in the high altitude mestizo Ecuadorian population Salivary MicroRNAs for Early Detection of Head and Neck Squamous Cell Carcinoma: A Case-Control Study in the High Altitude Mestizo Ecuadorian Population biomarker CBC 30584540 hsa-miR-1246 "Exosomal MicroRNA hsa-miR-1246 Promotes Cell Proliferation,Invasion and Drug Resistance by Targeting CCNG2 in Breast Cancer" "Hsa-miR-1246 promotes cell proliferation,invasion and drug resistance by targeting CCNG2 in breast cancer" molecular function MFBCE 29216623 hsa-miR-1246 Plasma exosome microRNAs are indicative of breast cancer "Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer" biomarker BBCE 27608715 hsa-miR-1246 Selective release of microRNA species from normal and malignant mammary epithelial cells MiR-1246 were also reported as valuable potential biomarkers of breast cancer biomarker CBC 20976003 hsa-miR-1246 "MiR-1246 promotes SiHa cervical cancer cell proliferation, invasion, and migration through suppression of its target gene thrombospondin 2" MiR-1246 might promote CSCC tumorigenesis and progression by the suppression of its target gene THBS2 molecular function CBC 24806621 hsa-miR-1246 Novel combination of serum microRNA for detecting breast cancer in the early stage "Combination of five miRNA (miR-246, miR-307-p, miR-634, miR-861-p and miR-875-p) was found to be able to detect breast cancer" biomarker CBC 26749252 hsa-miR-1246 Extracellular miR-1246 promotes lung cancer cell proliferation and enhances radioresistance by directly targeting DR5 "MiR-1246 could act as a signaling messenger between irradiated and non-irradiated cells, more importantly, it contributes to cell radioresistance by directly suppressing the DR5 gene" molecular function CBC 27129166 hsa-miR-1246 "Serum expression levels of microRNA-382-3p, -598-3p, -1246 and -184 in breast cancer patients" "MiR-382-3p, -598-3p, -1246 and -184 are all involved in the development of breast cancer, and are promising biomarkers for breast cancer detection" biomarker CBC 27347136 hsa-miR-1246 miRNA-1246 induces pro-inflammatory responses in mesenchymal stem/stromal cells by regulating PKA and PP2A "MiR-1246 led to a p65-dependent increase in transcription and release of pro-inflammatory mediators IL-6, CCL2 and CCL5 in MSCs, and increased NF-¦ÊB activity and promote inflammatory by direct targeting of the tumor-suppressors PRKAR1A and PPP2CB" molecular function CBC 28159925 hsa-miR-1246 MicroRNA-1246 inhibits cell invasion and epithelial mesenchymal transition process by targeting CXCR4 in lung cancer cells. miR-1246 inhibited cell invasion and EMT process by targeting CXCR4 and blocking JAK/STAT and PI3K/AKT signal pathways in lung cancer cells. biomarker CBC 29171984 hsa-miR-1246 MiR-1246 Promotes Metastasis and Invasion of A549 cells by Targeting GSK-3¦Â Mediated Wnt/¦Â-Catenin Pathway "miR-1246 regulates Wnt/¦Â-catenin pathway through targeting GSK-3¦Â/¦Â-catenin, which partly contributing to tumor metastasis.MiR-1246 may play an essential role in the diagnosis and therapeutic of lung cancer." molecular function CBC 30913872 hsa-miR-1246 microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer "Ex-miR-1246 expression correlated with increasing pathologic grade, positive metastasis, and poor prognosis" biomarker CBC 29437039 hsa-miR-1246 microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer "Overexpression of miR-1246 in a prostate cancer cell line significantly inhibited xenograft tumor growth in vivo and increased apoptosis and decreased proliferation, invasiveness, and migration in vitro miR-1246 inhibited N-cadherin and vimentin activities, thereby inhibiting epithelial-mesenchymal transition" molecular function CBC 29437039 hsa-miR-1246 Exosome-packaged miR-1246 contributes to bystander DNA damage by targeting LIG4. MiR-1246 packaged in exosomes could act as a transfer messenger and contribute to DNA damage by directly repressing the LIG4 gene molecular function CBC 30038324 hsa-miR-1246 In Situ Detection of Plasma Exosomal MicroRNA-1246 for Breast Cancer Diagnostics by a Au Nanoflare Probe "Using plasma miR-1246 level detected by our assay as a marker, we differentiated 46 breast cancer patients from 28 healthy controls with 100% sensitivity and 92.9% specificity at the best cutoff" biomarker CBC 30350935 hsa-miR-1268a Polymorphisms in the precursor microRNAs and aflatoxin B1-related hepatocellular carcinoma "Polymorphisms in pre-miRNAs, such as rs28599926 in miR-1268a, can be used as biomarkers for AFB1-related HCC" biomarker CBC 26152337 hsa-miR-1268a Prognostic significance of miR-1268a expression and its beneficial effects for post-operative adjuvant transarterial chemoembolization in hepatocellular carcinoma "MicroRNA-1268a may be an independent prognostic factor for HCC patients, and that decreasing microRNA-1268a expression may be beneficial for post-operative adjuvant TACE treatment in HCC" biomarker CBC 27796321 hsa-miR-1268a miR-1268a regulates ABCC1 expression to mediate temozolomide resistance in glioblastoma MiR-1268a and elucidated its role in modulating TMZ-resistance of GBM cells by targeting ABCC1 molecular function CBC 29876787 hsa-miR-1268a Distinct shed microvesicle and exosome microRNA signatures reveal diagnostic markers for colorectal cancer MiR-1268a was specifically enriched in SW480-Exos and miR-107 was enriched in only SW480-CL released EVs molecular function CBC 30608951 hsa-miR-1268a The microRNA-1268a rs28599926 polymorphism modified diffusely infiltrating astrocytoma risk and prognosis MiR-1268a rs28599926 polymorphism may be associated with DIA risk and prognosis biomarker CBC hsa-miR-128 Shikonin Inhibits the Proliferation of Human Breast Cancer Cells by Reducing Tumor-Derived Exosomes Hsa-miR-128 negatively regulates the level of Bax in MCF7recipient cells and inhibits cell proliferation molecular function MFBCE 27322220 hsa-miR-128 Reduced miR-128 in breast tumor-initiating cells induces chemotherapeutic resistance via Bmi-1 and ABCC5 "Reduction in miR-128 leading to Bmi-1 and ABCC5 overexpression is a stem cell-like feature of BT-ICs, which contributes to chemotherapeutic resistance in breast cancers. Ectopic expression of miR-128 sensitizes BT-ICs to the proapoptotic and DNA-damaging effects of doxorubicin, indicating therapeutic potential" molecular function CBC 21953503 hsa-miR-128 Loss of SNAIL regulated miR-128-2 on chromosome 3p22.3 targets multiple stem cell factors to promote transformation of mammary epithelial cells "In summary, we have identified a novel TGF-¦Â/SNAIL/miR-128 axis that provides a new avenue to understand the basis for oncogenic transformation of mammary epithelial cells" molecular function CBC 23019226 hsa-miR-128 miR-128 and its target genes in tumorigenesis and metastasis "Aberrant expression of miR-128 has been detected in many types of human tumors and its validated target genes are involved in cancer-related biological processes such as cell proliferation, differentiation and apoptosis" molecular function CBC 23958464 hsa-miR-128 miR-128 and miR-149 enhance the chemosensitivity of temozolomide by Rap1B-mediated cytoskeletal remodeling in glioblastoma "The expression of miR-128 and miR-149 was downregulated in glioblastoma, and their overexpression inhibited the invasion of glioblastoma cells by targeting Rap1B-mediated cytoskeletal and related molecular alterations" molecular function CBC 25017996 hsa-miR-128 MiR-128 regulation of glucose metabolism and cell proliferation in triple-negative breast cancer MiR-128 might be a prognostic marker and possible molecular target for therapy in patients with TNBC biomarker CBC 29116653 hsa-miR-128 MiR-128 regulation of glucose metabolism and cell proliferation in triple-negative breast cancer MiR-128 targeting inhibition of the insulin receptor and insulin receptor substrate 1 molecular function CBC 29116653 hsa-miR-130a Molecular characterization of exosome-like vesicles from breast cancer cells Comparing the miRNAs in MDA-Exo to MCF-Exo showed a higher expression of tumorigenic mir-130a in MDA-Exo. it has been shown that mir-130a contribute to tumorigenesis of colon cancer by regulating TGB-β/Smad signaling molecular function MFBCE 24468161 hsa-miR-130a "MicroRNA-130a inhibits cell proliferation, invasion and migration in human breast cancer by targeting the RAB5A" "MiR-130a is an important tumor suppressor in breast cancer, and imply that miR-130a/RAB5A axis have potential as therapeutic targets for breast cancer" molecular function CBC 25755726 hsa-miR-130a MiR-130a and MiR-374a Function as Novel Regulators of Cisplatin Resistance in Human Ovarian Cancer A2780 Cells The deregulation of miR-374a and miR-130a may be involved in the development and regulation of cisplatin resistance in ovarian cancer cells; miR-130a may be achieved by regulating the MDR1 and PTEN gene expression molecular function CBC 26043084 hsa-miR-130a miR-130a Deregulates PTEN and Stimulates Tumor Growth "MiR-130a overexpression in human breast cancer cells promoted Akt phosphorylation, cell survival, and tumor growth;MiR-130a as an oncogenic miRNA that targets PTEN to drive malignant cell survival and tumor growth" molecular function CBC 28935812 hsa-miR-130a microRNA-130a suppresses breast cancer cell migration and invasion by targeting FOSL1 and upregulating ZO-1 "MiR-130a directly targets FOSL1 and suppresses the inhibition of ZO-1, thus inhibiting cancer cell migration and invasion, in TNBCs" molecular function CBC 29384218 hsa-miR-130a miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity MiR-130a targeted molecular networks including TGF¦Â and IGF1R pathways were correlated with higher tumor stages in cancer patients to enhance host antitumor immunity molecular function CBC 29973593 hsa-miR-130a The MYB/miR-130a/NDRG2 axis modulates tumor proliferation and metastatic potential in salivary adenoid cystic carcinoma "MYB/miR-130a/NDRG2 axis, which modulates proliferation and metastasis in SACC, provides promising targets for the treatment of SACC" molecular function CBC 30206227 hsa-miR-130a MicroRNA-130a modulates a radiosensitivity of rectal cancer by targeting SOX4 MiR-130a functions as a radiosensitizer in rectal cancer and reveals a potential therapeutic target and preoperative prognostic marker for radiotherapy biomarker CBC 31387015 hsa-miR-130a-3p hsa-miR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells Hsa-miR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells molecular function MFBCE 29746865 hsa-miR-130a-3p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-130a-3p miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program MiR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation molecular function CBC 26436920 hsa-miR-130a-3p LncRNA CCAT1/miR-130a-3p axis increases cisplatin resistance in non-small-cell lung cancer cell line by targeting SOX4 "CCAT1/miR-130a-3p axis enhanced DDP resistance of NSCLC cells by targeting SOX4, providing potential targets to overcome DDP resistance and improve efficacy of chemotherapy for patients with NSCLC" molecular function CBC 29020498 hsa-miR-130a-3p MiR-130a-3p inhibits migration and invasion by regulating RAB5B in human breast cancer stem cell-like cells MiR-130a-3p may act as a disease progression monitoring indicator and therapeutic target in breast cancer molecular function CBC 29746865 hsa-miR-130a-3p H19 Functions as a Competing Endogenous RNA to Regulate EMT by Sponging miR-130a-3p in Glioma H19 and SOX4 are both direct target of miR-130a-3p. H19 could compete with SOX4 via sponging miR-130a-3p molecular function CBC 30282068 hsa-miR-130a-3p Complex role of miR-130a-3p and miR-148a-3p balance on drug resistance and tumor biology in esophageal squamous cell carcinoma A similar effect was observed for miR-130a-3p regulating Bcl-2 and XIAP. Our data provide the first evidence that miRNA modulation in both directions may lead to similar effects on chemotherapy response and tumor biology in esophageal squamous cell carcinoma molecular function CBC 30510209 hsa-miR-135a-3p MicroRNA-135a-3p as a promising biomarker and nucleic acid therapeutic agent for ovarian cancer MiR-135a-3p may be considered as a biomarker and a therapeutic agent in ovarian cancer biomarker CBC 28231414 hsa-miR-135a-3p miR-135a inhibits tumor metastasis and angiogenesis by targeting FAK pathway MiR-135a is a novel downstream gene of tumor suppressor p53;the expression and function of miR-135a in gastric cancer and uncovers a novel regulatory mechanism of miR-135a molecular function CBC 28415713 hsa-miR-135a-3p MicroRNA-135a-3p is downregulated and serves as a tumour suppressor in ovarian cancer by targeting CCR2 MiR-135a-3p serves as a tumour suppressor gene in ovarian cancer by regulating CCR2 molecular function CBC 30138893 hsa-miR-135a-3p miR-135a-3p as a promising biomarker and nucleic acid therapeutic agent for ovarian cancer MiR-135a-3p expression could be used as a noninvasive biomarker in serum of patients with ovarian carcinoma in the diagnosis and follow-up of the disease biomarker CBC hsa-miR-145 "Presence of Circulating hsa-miR-145, hsa-miR-155, and hsa-miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors" "Our study showed that serum-circulating miR-145, miR-155, and miR-382 are present in exosomes. These miRNAs were previously proposed as noninvasive biomarkers to distinguish between BC patients and healthy individuals" biomarker BBCE 30891102 hsa-miR-145 MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1. MiR-145 as a potential new diagnostic and therapeutic target for the treatment of breast cancer. biomarker CBC 26715279 hsa-miR-145 MicroRNA-145 inhibits growth and migration of breast cancer cells through targeting oncoprotein ROCK1. MiR-145 acts as a tumor suppressor and its downregulation in tumor tissues may contribute to the progression of breast cancer through a mechanism involving ROCK1 molecular function CBC 26715279 hsa-miR-145 MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer. MiR-145 might be potential therapeutic and diagnostic targets for TNBC. biomarker CBC 27364572 hsa-miR-145 MicroRNA-145 functions as a tumor suppressor by targeting matrix metalloproteinase 11 and Rab GTPase family 27a in triple-negative breast cancer. MiR-145 has an inhibitory role in TNBC malignancy by targeting MMP11 and Rab27a molecular function CBC 27364572 hsa-miR-145 miR-145 suppresses breast cancer cell migration by targeting FSCN-1 and inhibiting epithelial-mesenchymal transition. Ectopic expression of miR-145 significantly inhibited breast cancer cell migration. biomarker CBC 27508031 hsa-miR-145 miR-145 suppresses breast cancer cell migration by targeting FSCN-1 and inhibiting epithelial-mesenchymal transition. "MiR-145 mimic transfection enhanced the expression of FSCN-1 in Bcap-37 and HCC-1937 cells,up-regulation of miR-145 blocked EMT and decreased the expression of MMP-2/9 in breast cancer cells." molecular function CBC 27508031 hsa-miR-145 miR-145 inhibits proliferation and migration of breast cancer cells by directly or indirectly regulating TGF-¦Â1 expression. "MiR-145 may act as a tumor-suppressor miRNA in breast cancer through inhibiting proliferation and migration of breast cancer cells. In addition, miR-145 inhibits the protein expression of TGF-¦Â1 which may in turn contribute to tumor formation." molecular function CBC 28393176 hsa-miR-149-3p 18¦Â-glycyrrhetinic acid suppresses gastric cancer by activation of miR-149-3p-Wnt-1 signaling GRA inhibits the initiation and progression of gastric tumors by ameliorating the inflammatory microenvironment through downregulation of COX-2 expression and by inhibiting Wnt-1 expression through the upregulation of tumor suppressor miR-149-3p molecular function CBC 27713126 hsa-miR-149-3p "Regulation of PLK1 through competition between hnRNPK, miR-149-3p and miR-193b-5p" "HnRNPK regulates PLK1 expression by competing with the PLK1-targeting miRNAs, miR-149-3p and miR-193b-5p" molecular function CBC 28708135 hsa-miR-149-3p Dual Strands of Pre-miR-149?Inhibit Cancer Cell Migration and Invasion through Targeting?FOXM1?in Renal Cell Carcinoma Dual strands of pre-miR-149 (miR-149-5p and miR-149-3p) acted as antitumor miRNAs through the targeting of FOXM1 in ccRCC cells molecular function CBC 28902136 hsa-miR-149-3p "Expression of miR-149-3p inhibits proliferation, migration, and invasion of bladder cancer by targeting S100A4" "S100A4 promotes cell growth, migration, and invasion and can by reversed by miR-149-3p in BCa" molecular function CBC 29218245 hsa-miR-149-3p Characterizing the landscape of peritoneal exosomal microRNAs in patients with ovarian cancer by high-throughput sequencing MiR-149-3p and miR-222-5p might be novel biomarkers for evaluating the prognosis of patients with EOC and that these two miRNAs might have potential therapeutic values biomarker CBC 30655799 hsa-miR-149-3p ZEB1-AS1 initiates a miRNA-mediated ceRNA network to facilitate gastric cancer progression "ZEB1-AS1 can interact with specific miRNAs, forming a miRNA-mediated ceRNA network and promoting GC progress, partly through a ZEB1-AS1/miR-149-3p axis" molecular function CBC 30774556 hsa-miR-150-3p Antitumor miR-150-5p and miR-150-3p inhibit cancer cell aggressiveness by targeting SPOCK1 in head and neck squamous cell carcinoma Downregulation of both strands of pre-miR-150 (miR-150-5p and miR-150-3p) and overexpression of SPOCK1 contribute to the aggressive nature of HNSCC. The involvement of passenger strand miRNA in the regulation of HNSCC pathogenesis is a novel concept in RNA research molecular function CBC 29233721 hsa-miR-150-3p MiR-150-3p targets SP1 and suppresses the growth of glioma cells "The abundance of phosphatase and tension homolog deleted on chromosome ten (PTEN), a negative downstream target of SP1, was increased with the ectopic?miR-150-3p. Collectively, these results suggested that?miR-150-3p?suppressed the growth of glioma cells partially via regulating SP1 and possibly PTEN" molecular function CBC 29654167 hsa-miR-150-3p Molecular Pathogenesis of Gene Regulation by the miR-150 Duplex: miR-150-3p Regulates TNS4 in Lung Adenocarcinoma Expression of TNS4 was directly regulated by miR-150-3p in LUAD cells. Aberrant expression of TNS4 was detected in LUAD clinical specimens and its aberrant expression increased the aggressiveness of LUAD cells molecular function CBC 31052206 hsa-miR-155 Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Hsa-miR-155 has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 25446899 hsa-miR-155 "Presence of Circulating hsa-miR-145, hsa-miR-155, and hsa-miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors" "Our study showed that serum-circulating miR-145, miR-155, and miR-382 are present in exosomes. These miRNAs were previously proposed as noninvasive biomarkers to distinguish between BC patients and healthy individuals" biomarker BBCE 30891102 hsa-miR-155 miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. The location of tumor cells overexpressing miR-155 is a critical factor: in mammary fat pads miR-155 prevents tumor dissemination; whereas in the lung miR-155 apparently maintains the epithelial phenotype of tumor cells that is critical for macroscopic tumor formation. biomarker CBC 21460854 hsa-miR-155 miR-155 promotes macroscopic tumor formation yet inhibits tumor dissemination from mammary fat pads to the lung by preventing EMT. "Stable expression of miR-155 in 4T1 breast tumor cells reduces significantly the aggressiveness of tumor cell dissemination as a result of preventing epithelial-to-mesenchymal transition (EMT) of tumor cells in vivo. Further, miR-155 directly suppresses the expression of the transcription factor TCF4, which is an important regulator of EMT. However, when tumor cells are injected directly into the bloodstream, miR-155 remarkably promotes macroscopic tumor formation in the lung." molecular function CBC 21460854 hsa-miR-155 "MicroRNA-155 Regulates Cell Survival, Growth, and Chemosensitivity by Targeting FOXO3a in Breast Cancer" MiR-155 is a critical therapeutic target in breast cancer. biomarker CBC 27825093 hsa-miR-155 "MicroRNA-155 Regulates Cell Survival, Growth, and Chemosensitivity by Targeting FOXO3a in Breast Cancer" "The critical role of miR-155 in regulation of cell survival and chemosensitivity through down-regulation of FOXO3a in breast cancer. Ectopic expression of miR-155 induces cell survival and chemoresistance to multiple agents, whereas knockdown of miR-155 renders cells to apoptosis and enhances chemosensitivity." molecular function CBC 27825093 hsa-miR-155 "MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer" A transcriptional axis of FOXP3-BRCA1-miR-155 in breast cancer cells and show that plasma miR-155 may serve as a non-invasive biomarker for detection of early stage breast cancer. biomarker CBC 28562349 hsa-miR-155 "MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancer" "There was a positive correlation between expression of FOXP3 and miR-155 in breast cancer cell lines and primary breast cancers. In breast cancer cells, FOXP3 induced miR-155 through transcriptional repression of BRCA1." molecular function CBC 28562349 hsa-miR-16 MicroRNAs are exported from malignant cells in customized particles Hsa-miR-16 is characterized by excessive release from breast cancer cells while retaining relatively low concentrations of miRNA in the cells and could be used to detect the presence of malignant cells in the body molecular function MFBCE 22772984 hsa-miR-16 Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells "miR-16, a miRNA known to target VEGF, was enriched in MSC-derived exosomes and it was partially responsible for the anti-angiogenic effect of MSC-derived exosomes" molecular function MFBCE 24391924 hsa-miR-16 Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development MiR-16 is a tumor suppressor in progestin- and growth factor-induced growth in breast cancer molecular function CBC 22583478 hsa-miR-16 Circulating microRNAs as Specific Biomarkers for Breast Cancer Detection "MiR-16, miR-21 and miR-451 in plasma of breast cancer patients has been reported as biomarker " biomarker CBC 23301032 hsa-miR-16 MiR-16 family as potential diagnostic biomarkers for cancer: a systematic review and meta-analysis The clinical application of miR-16 family profiling for cancers diagnosis still needs further large-scale studies and additional improvements of substantiation biomarker CBC 25932099 hsa-miR-16 miR-16 promotes the apoptosis of human cancer cells by targeting FEAT MiR-16 is a tumor suppressor in cancer cells through the inhibition of FEAT translation molecular function CBC 26031775 hsa-miR-16 Global Analysis of miRNA-mRNA Interaction Network in Breast Cancer with Brain Metastasis "Hsa-miR-17-5p targeted mRNAs [such as BCL2, SMAD3,SOCS1 ]and pathways associated with epithelial-esenchymal transitions and other processes linked with cancer metastasis " biomarker CBC 28739740 hsa-miR-16 "MiR-16-5p targets SESN1 to regulate the p53 signaling pathway, affecting myoblast proliferation and apoptosis, and is involved in myoblast differentiation" "MiR-16-5p directly targets SESN1 to regulate the p53 signaling pathway, and therefore affecting myoblast proliferation and apoptosis" molecular function CBC 29511169 hsa-miR-17-5p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-17-5p Mir-17-5p Regulates Breast Cancer Cell Proliferation by Inhibiting Translation of AIB1 mRNA "Mir-17-5p, a potential translational repressor of the AIB1 oncogene, in the control of breast cancer cell proliferation" molecular function CBC 16940181 hsa-miR-17-5p miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1 MiR-17-5p plays an important role in breast cancer cell invasion and migration by suppressing HBP1 and subsequent activation of Wnt/¦Â-catenin molecular function CBC 20505989 hsa-miR-17-5p Global Analysis of miRNA-mRNA Interaction Network in Breast Cancer with Brain Metastasis "Hsa-miR-17-5p targeted mRNAs such as BCL2, SMAD3,SOCS1 and pathways associated with epithelial-esenchymal transitions and other processes linked with cancer metastasis " molecular function CBC 28739740 hsa-miR-17-5p miR-17-5p suppresses cell proliferation and invasion by targeting ETV1 in triple-negative breast cancer "MiR-17-5p acts as a tumour suppressor in TNBC by targeting ETV1, and a low-abundance of miR-17-5p may be involved in the pathogenesis of triple-negative breast cancer" molecular function CBC 29126392 hsa-miR-17-5p miR-106b-5p and miR-17-5p could predict recurrence and progression in breast ductal carcinoma in situ based on the transforming growth factor-beta pathway "MiR-106b-5p and miR-17-5p might have a role in breast cancer recurrence and progression by suppressing TGF-¦Â activity, leading to early breast cancer carcinogenesis" molecular function CBC 30989460 hsa-miR-181a-2-3p "let-7i-5p, miR-181a-2-3p and EGF/PI3K/SOX2 axis coordinate to maintain cancer stem cell population in cervical cancer" "While the EGF pathway promotes CSC formation in cervical cancer by inducing SOX2, miR-181a-2-3p/let-7i-5p counteracts the EGF pathway by inhibiting SOX2, thereby reducing the CSC population" molecular function CBC 29777148 hsa-miR-181d-3p Identification of common oncogenic and early developmental pathways in the ovarian carcinomas controlling by distinct prognostically significant microRNA subsets "For seven miRNAs (hsa-miR-134-3p, hsa-miR-134-5p, hsa-miR-181d-3p, hsa-miR-181d-5p, hsa-miR-494-3p, hsa-miR-494-5p, hsa-miR-517c-3p,hsa-miR-98-3p, hsa-miR-98-5p) the target mRNAs were found in micro-T-CDS only" molecular function CBC 28984201 hsa-miR-181d-3p "Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients" "MiR 125b-5p, miR 181d-3p, and miR 221-3p are useful in predicting poor prognosis in patients with MGMT-unmethylated glioblastomas" biomarker CBC 29538610 hsa-miR-181d-3p MiR-376b-3p Is Associated With Long-term Response to Sunitinib in Metastatic Renal Cell Carcinoma Patients "Out of these miRNAs, miR-488-3p, miR-186-3p, miR-122-5p, miR-181d-3p, miR-615-5p and miR376b-3p were selected for further validation based on the pvalue, fold-change, average expression and available literature evidence" molecular function CBC 31467229 hsa-miR-182 "hsa-miR-182,of the hsa-miR-183 cluster family,is packaged in exosomes and is detected in human exosomes from serum,breast cells and prostate cells" Hsa-miR-182 expression and secretion changes with breast cancer cell line aggressiveness.dependent mechanism;detectable in exosomes from human sera and may be transferred between cells via a microvesicle-dependent mechanism molecular function MFBCE 27446418 hsa-miR-182 Up-regulation of miR-182 by ¦Â-catenin in breast cancer increases tumorigenicity and invasiveness by targeting the matrix metalloproteinase inhibitor RECK "Our data demonstrate for the first time that miR-182 expression is controlled by ¦Â-catenin. In addition, we identify a new miR-182 target RECK which is important for miR-182-induced tumorigenesis" molecular function CBC 23333633 hsa-miR-182 Higher expression of circulating miR-182 as a novel biomarker for breast cancer The current study highlights results consistent with miR-182 as a novel and valuable biomarker for the diagnosis of BC biomarker CBC 24260062 hsa-miR-182 High expression of microRNA-183/182/96 cluster as a prognostic biomarker for breast cancer Our findings improve our understanding of the expression level of the miR-183/182/96 cluster in breast cancer and clarify the role of the miR-183/182/96 cluster as a novel prognostic biomarker for breast cancer biomarker CBC 27071841 hsa-miR-182 MiR-182 promotes proliferation and invasion and elevates the HIF-1¦Á-VEGF-A axis in breast cancer cells by targeting FBXW7 "In conclusion, our study explores a novel mechanism by which miR-182 elevates HIF-1¦Á expression to promote breast cancer progression" molecular function CBC 27648365 hsa-miR-182 MicroRNA-182 promotes proliferation and metastasis by targeting FOXF2 in triple-negative breast cancer MiR-182 plays an important role in the initiation and progression of TNBC by targeting FOXF2 and the miR-182/FOXF2 axis may present a new therapeutic strategy for TNBC in the future molecular function CBC 29085483 hsa-miR-187-5p MicroRNA deregulation in triple negative breast cancer reveals a role of miR-498 in regulating BRCA1 expression "In silico prediction revealed that miR-498 and miR-187-5p target BRCA1, and these results were confirmed by luciferase reporter assay,while miR-187-5p was found overexpressed in a luminal B cell line, miR-498 was highly expressed in a triple negative cell line, Hs578T, and its expression was negatively correlated with the levels of?BRCA1" molecular function CBC 26933805 hsa-miR-187-5p miR-187-5p Regulates Cell Growth and Apoptosis in Acute Lymphoblastic Leukemia via DKK2 "MiR-187-5p-DKK2 pathway regulates Wnt/¦Â-catenin signaling, cell growth, and apoptosis. Our findings provide the first evidence of a role for miR-187-5p in promotion of B-cell ALL" molecular function CBC 27296949 hsa-miR-187-5p "Oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer" "Oncogene miR-187-5p is associated with cellular proliferation, migration, invasion, apoptosis and an increased risk of recurrence in bladder cancer" molecular function CBC 29883941 hsa-miR-187-5p MicroRNAs as possible indicators of drug sensitivity in breast cancer cell lines By doing so hsa-miR-187-5p was linked to the cell cycle G2-M checkpoint in line with this checkpoint being the target of taxanes molecular function CBC 31063487 hsa-miR-18a-5p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-18a-5p MicroRNA-18a-5p functions as an oncogene by directly targeting IRF2 in lung cancer "MiR-18a-5p can not only promote NSCLC by suppressing IRF2, but also will be a promising target in the near future" molecular function CBC 28471447 hsa-miR-18a-5p "SREBP1, targeted by miR-18a-5p, modulates epithelial-mesenchymal transition in breast cancer via forming a co-repressor complex with Snail and HDAC1/2" "Due to crucial role of miR-18a-5p and SREBP1 in the EMT and metastasis, they provide promising drug targets for tailored therapy in the advanced breast cancer setting" molecular function CBC 29988076 hsa-miR-18a-5p "Long noncoding RNA GAS5 regulates the proliferation, migration, and invasion of glioma cells by negatively regulating miR-18a-5p" One miR-18a-5p-binding site within exon 2 of GAS5 that is partially responsible for the tumor-suppressor functions of GAS5 molecular function CBC 30078184 hsa-miR-18a-5p Carcinogenesis of miR-18a-5p was reversed by the overexpression of IRF2 in OS MiR-18a-5p promotes cell invasion and migration of osteosarcoma by directly targeting IRF2 biomarker CBC 30127908 hsa-miR-18a-5p miR-18a-5p promotes cell invasion and migration of osteosarcoma by directly targeting IRF2 MiR-18a-5p promoted the invasion and migration of OS cells through inhibiting IRF2 expression molecular function CBC 30127908 hsa-miR-191 Blood Circulating Exosomes Contain Distinguishable Fractions of Free and Cell-Surface-Associated Vesicles "Preliminary data indicated that detection of cancer-specific miRNA (miR-103, miR-191, miR-195) in exosomes associated with the fraction of red blood cells allowed to discriminate HFs and BCPs more precisely compared to cell-free exosomes circulating in plasma" biomarker BBCE 30868953 hsa-miR-191 "Differential expression of miR-21, miR-125b and miR-191 in breast cancer tissue." Two miRNA (miR-125b/miR-191 and miR-21/miR-191) can discriminate between breast cancer and non-tumor tissue with high specificity and sensitivity. biomarker CBC 22898264 hsa-miR-191 Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. "MiR-191 and miR-425 reduced proliferation, impaired tumorigenesis and metastasis, and increased expression of epithelial markers in aggressive breast cancer cells." biomarker CBC 23505378 hsa-miR-191 Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status. MiR-191 protects ER¦Á positive breast cancer cells from hormone starvation-induced apoptosis through the suppression of tumor-suppressor EGR1. molecular function CBC 23505378 hsa-miR-191 "MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer." "MiR-191 as an estrogen-inducible onco-miR in breast cancer, which promotes several hallmarks of cancer including enhanced cell proliferation, migration, chemoresistance and survival in tumor microenvironment." biomarker CBC 23542418 hsa-miR-191 "MicroRNA-191, an estrogen-responsive microRNA, functions as an oncogenic regulator in human breast cancer." The identification of estrogen/ER/miR-191/SATB1 cascade seems to be a significant pathway in estrogen signaling in breast cancer with miR-191 as oncogenic player. molecular function CBC 23542418 hsa-miR-191 HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGF¦Â-signaling in hypoxic microenvironment. "MiR-191 enhances breast cancer aggressiveness by promoting cell proliferation, migration and survival under hypoxia." biomarker CBC 25867965 hsa-miR-191 HIF-inducible miR-191 promotes migration in breast cancer through complex regulation of TGF¦Â-signaling in hypoxic microenvironment. "MiR-191 is a critical regulator of transforming growth factor beta (TGF¦Â)-signaling and promotes cell migration by inducing TGF¦Â2 expression under hypoxia through direct binding and indirectly by regulating levels of a RNA binding protein, human antigen R (HuR)." molecular function CBC 25867965 hsa-miR-195 Blood Circulating Exosomes Contain Distinguishable Fractions of Free and Cell-Surface-Associated Vesicles "Preliminary data indicated that detection of cancer-specific miRNA (miR-103, miR-191, miR-195) in exosomes associated with the fraction of red blood cells allowed to discriminate HFs and BCPs more precisely compared to cell-free exosomes circulating in plasma" biomarker BBCE 30868953 hsa-miR-195 Potentially predictive microRNAs of gastric cancer with metastasis to lymph node. MiR-212 and miR-195 could be independent biomarkers in predicting the gastric cancer with metastasis to lymph node(LN). biomarker CBC 21987613 hsa-miR-195 Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1 "Induction of miR-195 expression promoted tumor cell apoptosis and inhibited breast cancer cell viability, but induced the sensitivity of breast cancer cells to Adriamycin treatment and was associated with inhibition of Raf-1 expression in breast cancer cells. " biomarker CBC 23760062 hsa-miR-195 Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1 Expression of miR-195 or knockdown of Raf-1 can similarly reduce tumor cell survival but increase apoptosis through downregulation of Raf-1 and Bcl-2 and P-glycoprotein expression. molecular function CBC 23760062 hsa-miR-195 "MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1" "Hsa-miR-195 targets the genes of de novo lipogenesis, inhibits cell proliferation, migration, and invasion which potentially opens new avenues for the treatment of breast cancer." biomarker CBC 26632252 hsa-miR-195 "MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1" "Ectopic expression of hsa-miR-195 in MCF-7 and MDA-MB-231 cells not only altered cellular cholesterol and triglyceride levels significantly but also resulted in reduced proliferation, invasion and migration. Over expression of hsa-miR-195 decreased the Mesenchymal markers expression and enhanced Epithelial markers. " molecular function CBC 26632252 hsa-miR-195 Expression of tumor suppressors miR-195 and let-7a as potential biomarkers of invasive breast cancer The analysis of miR-195 and let-7a can be used as a non-invasive biomarker for breast cancer detection. biomarker CBC 29995098 hsa-miR-195-3p Identification of miR-195-3p as an oncogene in RCC Knockdown of miR-195-3p induces cell apoptosis;miR-195-3p promotes cell proliferation and increases cell mobility molecular function CBC 28260025 hsa-miR-195-3p Prostate cancer small non-coding RNA transcriptome in Arabs "Five miRNAs are newly found to be associated with PCa namely, miR-671-3p, miR-143-5p, miR-145-3p, miR-195-3p and miR-320b. Except for miR-671-3p, all other miRNAs were found down-regulated in tumor tissues" molecular function CBC 29268752 hsa-miR-195-3p Chemokine CCL4 induces vascular endothelial growth factor C expression and lymphangiogenesis by miR-195-3p in oral squamous cell carcinoma MiR-195-3p mimic reversed CCL4-enhanced VEGF-C expression. CCL4 stimulation of oral cancer cells augmented JAK2 and STAT3 phosphorylation molecular function CBC 29599774 hsa-miR-195-5p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-195-5p Upregulation of miR-195 increases the sensitivity of breast cancer cells to Adriamycin treatment through inhibition of Raf-1 Expression of miR-195 or knockdown of Raf-1 can similarly reduce tumor cell survival but increase apoptosis through downregulation of Raf-1 and Bcl-2 and P-glycoprotein expression molecular function CBC 23760062 hsa-miR-195-5p MicroRNA-195-5p is a potential diagnostic and therapeutic target for breast cancer "Overexpression of miR-195-5p inhibited cell proliferation, reduced cell colony formation, suppressed cell migration and caused an accumulation of cells in the G1 phase of the cell cycle" molecular function CBC 24402230 hsa-miR-195-5p Upregulation of miR-195 enhances the radiosensitivity of breast cancer cells through the inhibition of BCL-2 Exogenetic miR-195 expression could significantly enhance the radiosensitivity of human breast cancer cells; this finding may be attributed to BCL-2 downregulation to promote radiation-induced apoptosi molecular function CBC 26309570 hsa-miR-195-5p "MicroRNA-195 inhibits proliferation, invasion and metastasis in breast cancer cells by targeting FASN, HMGCR, ACACA and CYP27B1" "Hsa-miR-195 targets the genes of de novo lipogenesis, inhibits cell proliferation, migration, and invasion which potentially opens new avenues for the treatment of breast cancer" molecular function CBC 26632252 hsa-miR-1972 Identification and functional characterization of the miRNA-gene regulatory network in chronic myeloid leukemia lineage negative cells MiR-1972 induces G2-M cell cycle arrest and miR-1469 moderately arrested G1 cell cycle when overexpressed in KCL22 cells molecular function CBC 27586591 hsa-miR-1972 "Long noncoding RNA DANCR, working as a competitive endogenous RNA, promotes ROCK1-mediated proliferation and metastasis via decoying of miR-335-5p and miR-1972 in osteosarcoma" DNACR promoted ROCK1-meidated proliferation and metastasis through decoying both miR-335-5p and miR-1972 molecular function CBC 29753317 hsa-miR-197-5p "Comparative analysis of microRNA expression profiles between A549, A549/DDP and their respective exosomes" "The expression level of 5 microRNAs (miR-197-5p, miR-4443, miR-642a-3p, miR-27b-3p and miR-100-5p) with the most differential expression were verified by qRT-PCR;microRNAs in exosomes may be involved in the drug resistance of lung cancer cells to cisplatin" molecular function CBC 28178672 hsa-miR-197-5p miR-197-5p inhibits sarcomagenesis and induces cellular senescence via repression of KIAA0101 "MiR-197-5p acts as an oncosuppressor miRNA in fibrosarcoma through target regulation of KIAA0101, which can be exploited for developing RNA-based therapeutic strategies for the cure of this malignancy" molecular function CBC 31001891 hsa-miR-200 hsa-miR-200-containing extracellular vesicles promote breast cancer cell metastasis Promote mesenchymal-to-epithelial transition and colonisation of metastatic sites molecular function MFBCE 28038441 hsa-miR-200 miR-200 enhances mouse breast cancer cell colonization to form distant metastases "Expression of miR-200, which promotes a mesenchymal to epithelial cell transition (MET) by inhibiting Zeb2 expression, unexpectedly enhances macroscopic metastases in mouse breast cancer cell lines" molecular function CBC 19787069 hsa-miR-200 Epigenetic modulation of the miR-200 family is associated with transition to a breast cancer stem-cell-like state These results indicate that the miR-200 family plays a crucial role in the transition between stem-like and non-stem phenotypes and that distinct epigenetic-based mechanisms regulate each miR-200 gene in this process molecular function CBC 23525011 hsa-miR-200 MiR-200 can repress breast cancer metastasis through ZEB1-independent but moesin-dependent pathways "These findings highlight the context-dependent effects of miR-200 in breast cancer metastasis and demonstrate the existence of a moesin-dependent pathway, distinct from the ZEB1-E-cadherin axis, through which miR-200 can regulate tumour cell plasticity and metastasis" molecular function CBC 24037528 hsa-miR-200 miR-200-containing extracellular vesicles promote breast cancer cell metastasis "In murine cancer and human xenograft models, miR-200-expressing tumors and extracellular vesicles from these tumors promoted metastasis of otherwise weakly metastatic cells either nearby or at distant sites and conferred to these cells the ability to colonize distant tissues in a miR-200-dependent manner" molecular function CBC 25401471 hsa-miR-200 "MicroRNA-200, associated with metastatic breast cancer, promotes traits of mammary luminal progenitor cells" "We propose that microRNAs of the miR-200 family promote traits of highly proliferative breast luminal progenitor cells, thereby exacerbating the growth and metastatic properties of transformed mammary epithelial cells" molecular function CBC 29137351 hsa-miR-20b-5p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-20b-5p miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells The VEGF expression in breast cancer cells is mediated by HIF-1 and STAT3 in a miR-20b-dependent manner. molecular function CBC 20232316 hsa-miR-20b-5p MicroRNA-20b promotes cell growth of breast cancer cells partly via targeting phosphatase and tensin homologue (PTEN) "Dysregulation of miR-20b plays critical roles in the breast cancer tumorigenesis, at least in part via targeting the tumor suppressor PTEN" molecular function CBC 25364498 hsa-miR-20b-5p "miR-20b-5p may be a biomarker for early detection and prognosis prediction, as well as a therapeutic target for RCC" "MicroRNA-20b-5p functions as a tumor suppressor in renal cell carcinoma by regulating cellular proliferation, migration and apoptosis" biomarker CBC 26708577 hsa-miR-20b-5p Decreased expression of microRNA-17 and microRNA-20b promotes breast cancer resistance to taxol therapy by upregulation of NCOA3 "MiR-17, miR-20b and NCOA3 may serve as some predictive biomarkers and potential therapeutic targets in taxol-resistant breast cancer treatmen" molecular function CBC 27831559 hsa-miR-21 Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Hsa-miR-21 has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 25446899 hsa-miR-21 Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy "Higher levels of exosomal miRNA-21, miRNA-222, and miRNA-155 were significantly associated with the presence of circulating tumor cells;Liquid biopsies based on exosomal miRNAs and circulating tumor cells can be a complementary clinical tool for improving breast cancer diagnosis and prognosis" biomarker BBCE 30728048 hsa-miR-21 Plasma exosome microRNAs are indicative of breast cancer "Based on the selective enrichment and absolute abundance, we identified miR-1246, miR-122, miR-21, and let-7a as candidate exosome microRNAs that may serve as biomarkers indicative of breast cancer" biomarker BBCE 27608715 hsa-miR-21 MicroRNA-21 targets tumor suppressor genes in invasion and metastasis. Mir-21 may promote tumor invasion and metastasis by simultaneously downregulating multiple metastasis-related tumor suppressor genes operating at distinct steps of tumor progression. molecular function CBC 18270520 hsa-miR-21 "MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis." "MiR-21 overexpression was correlated with specific breast cancer biopathologic features, such as advanced tumor stage, lymph node metastasis, and poor survival of the patients, indicating that miR-21 may serve as a molecular prognostic marker for BC and disease progression." biomarker CBC 18812439 hsa-miR-21 "MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis." "Among the 113 BC cases, high level expression of miR-21 was significantly correlated with advanced clinical stage (P = 0.006, Fisher's exact text), lymph node metastasis (P = 0.007, Fisher's exact text), and shortened survival of the patients (hazard ratio [HR]=5.476, P < 0.001)." molecular function CBC 18812439 hsa-miR-21 High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. "High miR-21 was associated with poor disease-free survival in early stage patients (HR = 2.08, 95% CI: 1.08-4.00) despite no value for prognosis." biomarker CBC 18932017 hsa-miR-21 High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. "Elevated miR-21 expression may facilitate tumor progression, and TGF-beta may up-regulate its expression." molecular function CBC 18932017 hsa-miR-210 Visualization of exosome-mediated hsa-miR-210 transfer from hypoxic tumor cells Hsa-miR-210 can proliferate endothelial cells and promote tumor growth and invasion molecular function MFBCE 28038441 hsa-miR-210 Hypoxic enhancement of exosome release by breast cancer cells The hypoxically regulated miR-210 was identified to be present at elevated levels in hypoxic exosome fractions molecular function MFBCE 22998595 hsa-miR-210 hsa-miR-210 overexpression is induced by hypoxia in a HIF-1alpha- and VHL-dependent fashion Hsa-miR-210 Is induced by hypoxia and is an independent prognostic factor in breast cancer biomarker CBC 18316553 hsa-miR-210 hsa-miR-210 Is Induced by Hypoxia and Is an Independent Prognostic Factor in Breast Cancer Hsa-miR-210 overexpression is induced by hypoxia in a HIF-1¦Áand VHL-dependent fashion and its expression levels in breast cancer samples are an independent prognostic factor. biomarker CBC 18316553 hsa-miR-210 hsa-miR-210 overexpression is induced by hypoxia in a HIF-1alpha- and VHL-dependent fashion Expression levels of hsa-miR-210 in breast cancer samples are an independent prognostic factor molecular function CBC 18316553 hsa-miR-210 High Expression Levels of miR-21 and miR-210 Predict Unfavorable Survival in Breast Cancer: A Systemic Review and Meta-Analysis MiRNAs such as miR-21 and miR-210 can predict poor survival rates in breast cancer patients biomarker CBC 26349663 hsa-miR-222 Exosome-mediated hsa-miR-222 transferring: An insight into NF-B-mediated breast cancer metastasis Hsa-miR-222 contributes to tumorigenicity of BCa cells through down-regulation of PDLIM2 and consequently activating NF-¦ÊB molecular function MFBCE 29778754 hsa-miR-222 Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs Hsa-miR-222-rich D/exo could alter PTEN expression in acquired cells that may spread resistance capacity molecular function MFBCE 24740415 hsa-miR-222 Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy "Higher levels of exosomal miRNA-21, miRNA-222, and miRNA-155 were significantly associated with the presence of circulating tumor cells;Liquid biopsies based on exosomal miRNAs and circulating tumor cells can be a complementary clinical tool for improving breast cancer diagnosis and prognosis" biomarker BBCE 30728048 hsa-miR-222 MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer "MiR-221/222 in breast cancer metastasis, drug resistance and RAS pathways could potentially have applications in medical practice" molecular function CBC 21888691 hsa-miR-222 miR-221/222: promising biomarkers for breast cancer MiR-221/222 act as promising biomarkers for BCa and they would offer a new way in molecular targeting cancer treatment biomarker CBC 23529451 hsa-miR-222 MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway Inhibition of miR-222 may improve the prognosis of breast cancer patients biomarker CBC 27746366 hsa-miR-222 MiR-222 promotes drug-resistance of breast cancer cells to adriamycin via modulation of PTEN/Akt/FOXO1 pathway MiR-222 mediated ADR-resistance of breast cancer cells partly through regulation of PTEN/Akt/FOXO1 signaling pathway molecular function CBC 27746366 hsa-miR-222 Expression Analysis of MicroRNA-222 in Breast Cancer Our findings on miR-222 suggest that it could be a potentially useful target for control and management of breast malignancy biomarker CBC 29739090 hsa-miR-222 miR-221/222 activate the Wnt/¦Â-catenin signaling to promote triple-negative breast cancer "MiR-221/222 activate the Wnt/¦Â-catenin signaling to promote the aggressiveness and TNBC properties of breast cancers, and thus reveal a new prospect for TNBC treatment" molecular function CBC 30053090 hsa-miR-223 Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells MiR-223 promoted the invasion of breast cancer cells via the Mef2c-¦Â-catenin pathway molecular function MFBCE 21939504 hsa-miR-223 Identification and validation of oncologic miRNA biomarkers for luminal A-like breast cancer "MiR-29a, miR-181a, miR-223 and miR-652 were validated with altered expression in the blood of women with Luminal A-like breast cancer" biomarker CBC 24498016 hsa-miR-223-3p Exosome-encapsulated microRNA-223-3p as a minimally invasive biomarker for the early detection of invasive breast cancer Exosomal miR-223-3p may be a useful preoperative biomarker to identify the invasive lesions of DCIS patients diagnosed by biopsy biomarker BBCE 29805680 hsa-miR-223-3p MiR-223-3p targeting SEPT6 promotes the biological behavior of prostate cancer "Increasing SEPT6 expression might reverse the biological activity induced by miR-223-3p, which might be a potential therapeutic target for PCa" molecular function CBC 25519054 hsa-miR-223-3p MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion "MiR-223-3p as a previously unrecognized microRNA that inhibits bladder carcinoma invasiveness via nuclear receptor coactivator 1, and this finding may be important for developing innovative therapeutic targets in treating bladder carcinoma" molecular function CBC 28222670 hsa-miR-223-3p MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression MiR-223-3p could be a potential therapeutic for ovarian cancer biomarker CBC 28587313 hsa-miR-223-3p MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression MiR-223-3p regulated OC cell proliferation and invasion through targeting SOX11 expression molecular function CBC 28587313 hsa-miR-223-3p MiR-223-3p inhibits angiogenesis and promotes resistance to cetuximab in head and neck squamous cell carcinoma Expression levels of miR-223-3p can be evaluated as an indicator of eligibility for non-treatment of HNSCC patients with cetuximab biomarker CBC 28915663 hsa-miR-223-3p MiR-223-3p functions as a tumor suppressor in lung squamous cell carcinoma by miR-223-3p-mutant p53 regulatory feedback loop "MiR-223-3p, as a tumor suppressor gene, markedly inhibited cell proliferation and migration via miR-223-3p-mutant p53 feedback loop, which suggested miR-223-3p might be a new therapeutic target in LSCC bearing p53 mutations" molecular function CBC 30755230 hsa-miR-223-3p MiR223-3p promotes synthetic lethality in BRCA1-deficient cancers MiR223-3p is a negative regulator of the aNHEJ DNA repair and represents a therapeutic pathway for BRCA1- or BAP1-deficient cancers molecular function CBC 31395736 hsa-miR-25-5p Genome-Wide Uncovering of STAT3-Mediated miRNA Expression Profiles in Colorectal Cancer Cell Lines MiR-25-5p was the most abundant miRNA among those significantly downregulated miRNAs in both samples molecular function CBC 25126546 hsa-miR-25-5p Silencing protein kinase C ¦Æ by microRNA-25-5p activates AMPK signaling and inhibits colorectal cancer cell proliferation "Exogenous expression of miR-25-5p silenced PKC¦Æ to activate AMPK signaling, which inhibited HT-29 cell proliferation. In vivo studies showed that HT-29 xenograft growth in mice was inhibited after expressing PKC¦Æ shRNA or miR-25-5p" molecular function CBC 29029434 hsa-miR-27a Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Hsa-miR-27a has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 25446899 hsa-miR-27a MiR-27 as a prognostic marker for breast cancer progression and patient survival. "High miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression." biomarker CBC 23240057 hsa-miR-27a microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. MiR-27a and miR-27b expression may be pharmacologically relevant modulators of DPD enzyme function in the liver. biomarker CBC 24401318 hsa-miR-27a microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. Increased accumulation of RNA-induced silencing complex (RISC) proteins on DPYD mRNA in cells overexpressing the highly homologous microRNAs (miRNA) miR-27a and miR-27b. These miRNAs were shown to repress DPD expression through two conserved recognition sites in DPYD. molecular function CBC 24401318 hsa-miR-27a MicroRNA-27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. MiR-27a exhibits an essential role in tumor development and progression in TNBC and may be used as a potential biomarker to predict radiotherapy response and prognosis for the disease. biomarker CBC 29115608 hsa-miR-27a MicroRNA-27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. "MiR-27a inhibited radiation induced apoptosis in TNBC cells by regulation of caspase 3/7 and Bcl-2 expression. Furthermore, the expression levels of PTEN and phosphorylated protein kinase B in MDA-MB-231 and MDA?MB?468 cells was altered following overexpression of miR-27a. The luciferase assay demonstrated that miR?27a regulated PTEN and BAX expression by binding to 3'?untranslated regions." molecular function CBC 29115608 hsa-miR-27a miR-27a promotes human breast cancer cell migration by inducing EMT in a FBXW7-dependent manner "The important function of miR-27a in regulating the metastasis of breast cancer in a FBXW7-dependent manner, and provide evidence for the potential application of miR-27a in breast cancer therapy." biomarker CBC 30365154 hsa-miR-27a miR-27a promotes human breast cancer cell migration by inducing EMT in a FBXW7-dependent manner "Overexpression of miR-27a resulted in enhanced cell migration by inducing epithelial-to-mesenchymal transition, while its knockdown effectively reversed these cellular events.F-box and WD repeat domain containing 7 (FBXW7) is a downstream target gene of miR-27a in human breast cancer cells.the ectopic expression of FBXW7 may effectively suppress the epithelial-to-mesenchymal transition and migratory activity of breast cancer cells, in addition to reversing the cell migration mediated by miR-27a." molecular function CBC 30365154 hsa-miR-29b-3p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-29b-3p LncRNA H19/miR-29b-3p/PGRN Axis Promoted Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Acting on Wnt Signaling The lncRNA H19/miR-29b-3p/PGRN/Wnt axis counted a great deal for seeking appropriate diagnostic biomarkers and treatment targets for CRC biomarker CBC 29754471 hsa-miR-29b-3p The role of lncRNA MSC-AS1/miR-29b-3p axis-mediated CDK14 modulation in pancreatic cancer proliferation and Gemcitabine-induced apoptosis MSC-AS1/miR-29b-3p axis modulates the cell proliferation and GEM-induced cell apoptosis in PDAC cell lines through CDK14 molecular function CBC 30915884 hsa-miR-29b-3p miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3 "The miR-29b-3p expression was significantly increased in MDA-MB-231 compare with MCF-10A. miR-29b-3p inhibitor reduced the cell viability of MDA-MB-231 and inhibited cell migration and invasion. Cell cytoskeleton integrity destroyed after miR-29b-3p inhibitor treatment. Furthermore, we identified the mechanism and found miR-29b-3p targets the TRAF3 and activates NF-κB signaling pathway" molecular function CBC 31349873 hsa-miR-29b-3p "Sulforaphane modulates microRNA expression in colon cancer cells to implicate the regulation of oncogenes CDC25A, HMGA2 and MYC" "MiR-29b-3p is predicted to target a number of tumour-suppressing genes, further investigation of which could be informative regarding the potential of sulforaphane to suppress tumour progression" molecular function CBC hsa-miR-301a Molecular characterization of exosome-like vesicles from breast cancer cells "MCF-Exo contains a higher amount of hsa-miR-301a,and overexpression has been considered a negative prognostic indicator in lymph node-negative (LNN) invasive ductal breast cancer" molecular function MFBCE 24468161 hsa-miR-301a MicroRNA-301 mediates proliferation and invasion in human breast cancer MiR-301 as a crucial oncogene in human breast cancer that acts through multiple pathways and mechanisms to promote nodal or distant relapses molecular function CBC 21393507 hsa-miR-301a Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/¦Â-catenin signaling MiR-301a might be a potential target in breast cancer therapy biomarker CBC 24315818 hsa-miR-301a Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/¦Â-catenin signaling "MiR-301a directly targeted and suppressed PTEN, one negative regulator of the Wnt/¦Â-catenin signaling cascade" molecular function CBC 24315818 hsa-miR-301a Elevated miR-301a expression indicates a poor prognosis for breast cancer patients "MiR-301a should be considered, and novel therapeutic options are needed to target this aggressive miR-301a-positive type of breast cancer to reduce recurrence and the mortality rate" biomarker CBC 29396508 hsa-miR-301a MiR-301a-3p Suppresses Estrogen Signaling by Directly Inhibiting ESR1 in ER¦Á Positive Breast Cancer "ESR1 as a direct target of miR-301a-3p and suggest that miR-301a-3p likely contributes to development of estrogen independence, which leads to a more invasive phenotype of breast cancer" molecular function CBC 29763890 hsa-miR-301a hsa-miR-301a- and SOX10-dependent miRNA-TF-mRNA regulatory circuits in breast cancer Regulatory motifs involving miRNAs and TFs may be useful for understanding breast cancer regulation and for predicting new biomarkers biomarker CBC 30814872 hsa-miR-301a hsa-miR-301a- and SOX10-dependent miRNA-TF-mRNA regulatory circuits in breast cancer "The following significant circuits were characterized and validated bioinformatically by using web-based tools: SOX10-sa-miR-301a-OXA3, SOX10-sa-miR-301a-IT, and SOX10-sa-miR-301a-FIB" molecular function CBC 30814872 hsa-miR-30a Exosomes from Drug-Resistant Breast Cancer Cells Transmit Chemoresistance by a Horizontal Transfer of MicroRNAs "Target gene prediction and pathway analysis showed the involvement of miR-100, miR-222, and miR-30a in pathways implicated in cancer pathogenesis, membrane vesiculation and therapy failure,the transmition of chemoresistance by a horizontal transfer of miRNAs" molecular function MFBCE 24740415 hsa-miR-30a MicroRNA miR-30 family regulates non-attachment growth of breast cancer cells MiR30-family regulates the growth of breast cancer cells in non-attachment conditions molecular function CBC 23445407 hsa-miR-30a miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2 MiR-30a/Eya2 axis may play an important role in breast cancer development and progression and that miR-30a activation or Eya2 inhibition may be a useful strategy for cancer treatment molecular function CBC 24508260 hsa-miR-30a The Versatile Role of microRNA-30a in Human Cancer MiR-30a may serve as a potential target in the diagnosis and therapy of human cancer biomarker CBC 28359057 hsa-miR-30a miR-30a inhibits the biological function of breast cancer cells by targeting Notch1 "MiR-30a attenuates the development of breast cancer by regulating the expression of the downstream target gene, Notch1" molecular function CBC 28765900 hsa-miR-30a A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness "The existence of a novel axis linking p53 to EMT via miR-30a, and adds support to the notion that miRNAs represent key elements of the complex network whereby p53 inactivation affects TNBC clinical behavior" molecular function CBC 29666469 hsa-miR-31 hsa-miR-31 shuttled by halofuginone-induced exosomes suppresses MFC-7 cell proliferation by modulating the HDAC2/cell cycle signaling axis Hsa-miR-31 modulates MCF-7 cells growth by specially targeting the histone deacetylase 2 molecular function MFBCE 30916359 hsa-miR-31 "A Pleiotropically Acting microRNA, miR-31, Inhibits Breast Cancer Metastasis" MiR-31 uses multiple mechanisms to oppose metastasis molecular function CBC 19524507 hsa-miR-31 miR-155 and miR-31 are differentially expressed in breast cancer patients and are correlated with the estrogen receptor and progesterone receptor status These results suggest that miR-155 and miR-31 are differentially expressed in breast cancer patients. Their correlation with the clinicopathological characteristics may aid the diagnosis and treatment of invasive intraductal breast cancer biomarker CBC 23162645 hsa-miR-31 A novel mechanism of regulation of the anti-metastatic miR-31 by EMSY in breast cancer "This regulation is dependent on the DNA-binding transcription factor ETS-1 which recruits EMSY and the histone demethylase KDM5B to the miR-31 promoter, thus repressing its transcription" molecular function CBC 25927669 hsa-miR-31 MiR-31 inhibits migration and invasion by targeting SATB2 in triple negative breast cancer MiR-31 inhibited TNBC cells migration and invasion through suppressing SATB2 expression molecular function CBC 27593563 hsa-miR-3126-3p Evaluation of Plasma Extracellular Vesicle MicroRNA Signatures for Lung Adenocarcinoma and Granuloma With Monte-Carlo Feature Selection Method "In EV, the top 10 discriminative miRNAs were hsa-miR-23b-3p, hsa-miR-548ac, hsa-miR-3126-3p, hsa-miR-15b-5p, hsa-miR-205-5p, hsa-miR-5010-5p, hsa-miR-331-5p, hsa-miR-1249-3p, hsa-miR-548c-5p, and hsa-miR-1827" molecular function CBC 31105742 hsa-miR-3147 Serum microRNA expression levels can predict lymph node metastasis in patients with early-stage cervical squamous cell carcinoma Serum miR-3147 expression levels can predict metastasis in patients with early-stage cervical squamous cell carcinoma biomarker CBC 23799609 hsa-miR-3147 miR-3147 serves as an oncomiR in vulvar squamous cell cancer via Smad4 suppression MiR-3147 may represent a novel potential therapeutic target marker for VSCC. biomarker CBC 29512734 hsa-miR-3147 miR-3147 serves as an oncomiR in vulvar squamous cell cancer via Smad4 suppression MiR-3147 may serve an oncogenic role in VSCC by targeting Smad4 molecular function CBC 29512734 hsa-miR-3151-5p MicroRNAs Responsible for Inflammation in Obesity "The analysis identified 19 high scoring microRNAs (miR-146, miR-378, miR-143, miR-145, miR-194, miR-1273, miR-190, miR-561, miR-151, miR-215, miR-196, miR-328, miR-208, miR-3155A, miR-933, miR-4685, miR-640, miR-4659, and miR-877)" molecular function CBC hsa-miR-3153 Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles "Twelve miRNAs were downregulated (miR-10a, miR-135a, miR-299-3p, miR-3126-5p, miR-3153, miR-411, miR-4321, miR-486-5p, miR-505, miR-598, miR-601, miR-939) after antroquinonol treatment" molecular function CBC 21185843 hsa-miR-3153 Plasma microRNA alterations between EGFR-activating mutational NSCLC patients with and without primary resistance to TKI "MiRNA microarray of plasma from patients' blood identified 16 differentially expressed miRNAs of which 15 (hsv2-miR-H19, hsa-miR-744-5p, hsa-miR-3196, hsa-miR-3153, hsa-miR-4791, hsa-miR-4803, hsa-miR-4796-3p, hsa-miR-372-5p, hsa-miR-138-2-3p, hsa-miR-16-1-3p, hsa-miR-1469, hsa-miR-585-3p, ebv-miR-BART14-5p, hsa-miR-769-3p, hsa-miR-548aq-5p) were down regulated while only hsa-miR-503-3p was up regulated in primary resistant patients' plasma" molecular function CBC 29179454 hsa-miR-3155a MiRNA-3670 and miR-8078 Induce the Apoptosis Mediated by SERPINB5 in Lung Cancers MiRNA-3670 and miR-8078 Induce the Apoptosis Mediated by SERPINB5 in Lung Cancers molecular function CBC hsa-miR-3161 Differential exosomal microRNA profile in the serum of a patient with depression NCBI "There were 12 up-regulated miRNAs: hsa-miR-1255a, hsa-miR-3161, hsa-miR-99a-3p, hsa-miR-205-5p, hsa-miR-26a-1-3p, hsa-miR-139-5p, hsa-miR-7849-3p, hsa-miR-195-5p, hsa-miR-125b-2-3p, hsa-miR-664a-3p, hsa-let-7c-5p, and hsa-miR-197-3p." molecular function CBC 29050253 hsa-miR-3161 Overexpression of miRNA 4451 is Associated With a Poor Survival of Patients With Hypopharyngeal Cancer After Surgery With Postoperative Radiotherapy "MiR-200c, miR-429, and miR-4701 were down-regulated, whereas miR-3161, miR-3605-5p, miR-378b, and miR-4451 were up-regulated in the death group compared with those in the alive group" molecular function CBC 30103154 hsa-miR-3161 Identification of miR-708-5p in peripheral blood monocytes: Potential marker for postmenopausal osteoporosis in Mexican-Mestizo population "We identified six candidate microRNAs: four were up-regulated (miR-708-5p, miR-34b-5p, miR-3161, miR-328-5p), while two were down-regulated (miR-4422 and miR-939-3p) in osteoporotic women" molecular function CBC 30322266 hsa-miR-3175 Primary analysis and screening of microRNAs in gastric cancer side population cells "There are key miRNAs expressed within the SP cells of the gastric cancer cell line MKN-45, and include hsa-miR-3175, hsa-miR-203, hsa-miR-130a, hsa-miR-324-5p, hsa-miR-34a, and hsa-miR-25-star" molecular function CBC 25834316 hsa-miR-3175 Detection of Potential Metastatic Prostate Cancer Circulating Biomarkers by Comparison of miRNA Profiles in DU145 Cells and Culture Medium "Three of these miRNA, hsa-miR-4417, hsa-miR-3175, and hsa-miR-6782-5p, exhibit the highest expression and are candidate circulating biomarkers for metastatic activity of prostate cancer." biomarker CBC 28429232 hsa-miR-3176 Exosome-derived microRNAs contribute to prostate cancer chemoresistance "The hub AR and PTEN target genes mainly regulated by upregulated miRNAs (hsa-miR-16-5p, -23c, -32-5p, -3915, -5004-5p, -488-3p, -3673 and -3654) and downregulated miRNAs (hsa-miR-3176 and -141-3p)" molecular function CBC 27278879 hsa-miR-3176 A microRNA expression signature for clinical response in locally advanced cervical cancer "The miRNAs reported here, including miR-3176, miR-3676, miR-502, miR-128, miR-145, miR-651, miR-299, miR-548, and miR-345, are for the first time associated with the development of resistance in LACC patients" molecular function CBC 27423381 hsa-miR-3185 MicroRNA expressions associated with progression of prostate cancer cells to antiandrogen therapy resistance "MiRNAs -454, -3131 and -3185 are noted for the first time to be deregulated during progression of CRPC" molecular function CBC 24387052 hsa-miR-3185 "MicroRNAs are part of the regulatory network that controls EGF induced apoptosis, including elements of the JAK/STAT pathway, in A431 cells" "MiRNAs (miR-663, miR-499-5p, miR-494, miR-602, miR-2861, miR-675 and miR-3185) may have crucial functions in A431 cell apoptosis through a process involving epidermal growth factor (EGF) involvement" molecular function CBC 25781916 hsa-miR-3185 microRNA miR-3185 mediated alternative translation initiation of peroxiredoxin 5 mRNA in human breast cancer cells Increase in the oxidation state leads to an increased expression of hsa-miR-3185. Increase amount of miR-3185 leads to an increase in short form of PRDX5 translation from the second AUG perhaps by blocking the translation initiation from the first AUG codon molecular function CBC hsa-miR-3188 miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR-PI3K/AKT-c-JUN "As a tumour suppressor, miR-3188 directly targets mTOR to stimulate its own expression and participates in FOXO1-mediated repression of cell growth, tumorigenesis and NPC chemotherapy resistance" molecular function CBC 27095304 hsa-miR-3188 "miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway" MiR-3188 may serve as a potential therapeutic agent for the treatment of breast cancer biomarker CBC 28560951 hsa-miR-3188 "miR-3188 Regulates Cell Proliferation, Apoptosis, and Migration in Breast Cancer by Targeting TUSC5 and Regulating the p38 MAPK Signaling Pathway" "MiR-3188 affects breast cancer cell proliferation, apoptosis, and migration by targeting TUSC5 and activating the p38 MAPK signaling pathway" molecular function CBC 28560951 hsa-miR-3188 Hepatitis B virus X protein promotes CREB-mediated activation of miR-3188 and Notch signaling in hepatocellular carcinoma The HBx-miR-3188-ZHX2-Notch1 signaling pathway plays an important role in the pathogenesis and progression of HBV-related HCC with family history of HCC molecular function CBC 28574502 hsa-miR-3188 MiR-3188 Inhibits Non-small Cell Lung Cancer Cell Proliferation Through FOXO1-Mediated mTOR-p-PI3K/AKT-c-JUN Signaling Pathway MiR-3188 interacts with mTOR and FOXO1 to inhibit NSCLC cell proliferation through a mTOR-p-PI3K/AKT-c-JUN signaling pathway molecular function CBC 30618730 hsa-miR-3188 Loss of exosomal miR-3188 in cancer-associated fibroblasts contributes to HNC progression The potential therapeutic value of exosomal miR-3188 for inhibiting HNC growth. molecular function CBC 30961650 hsa-miR-3196 MicroRNA-3196 is inhibited by H2AX phosphorylation and attenuates lung cancer cell apoptosis by downregulating PUM H2AX phosphorylation regulates apoptosis in lung cancer cells via the miR-3196/PUMA pathway molecular function CBC 27780918 hsa-miR-3196 Overexpression of miR-3196 suppresses cell proliferation and induces cell apoptosis through targeting ERBB3 in breast?cancer MiR-3196 can serve as a potential biomarker and therapeutic target for breast cancer biomarker CBC 30556879 hsa-miR-3196 Overexpression of miR-3196 suppresses cell proliferation and induces cell apoptosis through targeting ERBB3 in breast?cancer MiR-3196 was lowly expressed in breast cancer tissues. Overexpression of miR-3196 could repress the proliferation and induce the apoptosis of breast cancer cells via targeting the 3'UTR of ERBB3 molecular function CBC 30556879 hsa-miR-3196 "Long noncoding RNA ADPGK-AS1 promotes cell proliferation, migration, and EMT process through regulating miR-3196/OTX1 axis in breast cancer" ADPGK-AS1 acted as a competing endogenous RNA (ceRNA) via modulating miR-3196/OTX1 axis in BC molecular function CBC 31264061 hsa-miR-3196 Genome-wide analysis of microRNA signature in lung adenocarcinoma with EGFR exon 19 deletion MicroRNAs associate with EGFR exon 19 deletion and miR-3196 can be further explored for potential predictor and targeted biomarker when it is difficult to get the tumors biomarker CBC hsa-miR-328 Molecular characterization of exosome-like vesicles from breast cancer cells "MDA-Exo also contains significant amounts of hsa-miR-328,which has been shown to target CD44,reduce cell adhesion,enhance cell migration and regulate capillary structure formation" molecular function MFBCE 24468161 hsa-miR-328 MicroRNA-328 negatively regulates the expression of breast cancer resistance protein (BCRP/ABCG2) in human cancer cells MiR-328 targets ABCG2 3'-UTR and controls ABCG2 protein expression and influences drug disposition in human breast cancer cells molecular function CBC 19270061 hsa-miR-328 "Breast cancer resistance protein BCRP/ABCG2 regulatory microRNAs (hsa-miR-328, -519c and -520h) and their differential expression in stem-like ABCG2+ cancer cells" "MiR-519c and -328 have greater impact on ABCG2 expression than miR-520h in MCF-7 human breast cancer cells, and the presence of proximal miR-519c MRE explains the action of miR-519c on shortened ABCG2 3'UTR" molecular function CBC 21219875 hsa-miR-328 Prognostic microRNA/mRNA signature from the integrated analysis of patients with invasive breast cancer "The prognostic RNAs included PIK3CA, one of the two most frequently mutated genes in IDC, and miRNAs such as hsa-miR-328, hsa-miR-484, and hsa-miR-874" biomarker CBC 23589849 hsa-miR-338-3p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-338-3p miR-338-3p Suppresses Gastric Cancer Progression through a PTEN-AKT Axis by Targeting P-REX2a "MiR-338-3p affects gastric cancer progression through PTEN-AKT signaling by targeting P-Rex2a in gastric cancer cells, which posits miR-338-3p as a novel strategy for gastric cancer treatment" molecular function CBC 24375644 hsa-miR-338-3p MicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4 "MiR-338-3p may act as a tumor suppressor in breast cancer by targeting SOX4, suggesting miR?338-3p as a novel strategy for breast cancer treatment" molecular function CBC 26252944 hsa-miR-338-3p The EGFR/miR-338-3p/EYA2 axis controls breast tumor growth and lung metastasis MiR-338-3p/EYA2 axis contributes to EGFR-mediated tumor growth and lung metastasis and that miR-338-3p activation or EYA2 inhibition or combination therapy targeting EGFR/miR-338-3p/EYA2 axis may be a promising way to treat patients with metastatic cancer molecular function CBC 28703807 hsa-miR-338-3p miR-338-3p inhibits the invasion of renal cell carcinoma by downregulation of ALK5 MiR-338-3p acts as a novel tumor suppressor to inhibit the invasion of RCC by regulating ALK5 expression molecular function CBC 28969055 hsa-miR-338-3p miR-338-3p targets RAB23 and suppresses tumorigenicity of prostate cancer cells MiR-338-3p acts as a tumor suppressor in prostate cancer by directly targetingRAB23 molecular function CBC 30662812 hsa-miR-340-5p Differential expression of exosomal miRNAs between breast cancer patients with and without recurrence "Of 384 miRNAs, three miRNAs (miR-338-3p, miR-340-5p, and miR-124-3p) were significantly upregulated and eight (miR-29b-3p, miR-20b-5p, miR-17-5p, miR-130a-3p, miR-18a-5p, miR-195-5p, miR-486-5p, and miR-93-5p) were significantly downregulated in the patients with recurrence" biomarker BBCE 29050253 hsa-miR-340-5p MicroRNA-340-5p modulates cisplatin resistance by targeting LPAAT¦Â in osteosarcoma MiR-340-5p enhanced the sensitivity to CDDP by targeting LPAAT¦Â molecular function CBC 28443990 hsa-miR-340-5p MiR-340-5p is a potential prognostic indicator of colorectal cancer and modulates ANXA3 MiR-340-5p might represent a novel prognostic biomarker and therapeutic target for CRC biomarker CBC 30070320 hsa-miR-340-5p MiR-340-5p is a potential prognostic indicator of colorectal cancer and modulates ANXA3 MiR-340-5p exerted its tumor-suppressive function by directly targeting ANXA3 in CRC molecular function CBC 30070320 hsa-miR-340-5p MicroRNA-340-5p suppresses non-small cell lung cancer cell growth and metastasis by targeting ZNF503 MiR-340-5p inhibits NCI-H1650 cell proliferation and invasion by directly targeting ZNF503 and that miR-340-5p can serve as a potential therapeutic target for treating NSCLC molecular function CBC 31160893 hsa-miR-340-5p miR-340-5p Suppresses Aggressiveness in Glioblastoma Multiforme by Targeting Bcl-w and Sox2 Our novel findings highlight the potential utility of miR-340-5p as a therapeutic agent for glioblastoma multiforme through inhibitory effects on Bcl-w-induced PDGF-A and Sox2 activation molecular function CBC 31272074 hsa-miR-34a Molecular characterization of exosome-like vesicles from breast cancer cells "MCF-Exo also contains mir-34a, which regulates several genes including p53" molecular function MFBCE 24468161 hsa-miR-34a MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer MiR-34a expression activation is a marker of aggressive breast tumour phenotype it exerts an independent effect for a lower risk of recurrence or death from breast cancer biomarker CBC 22102859 hsa-miR-34a MicroRNA-34a: a potential therapeutic target in human cancer "Early studies have shown that miR-34a acts as a tumor-suppressor gene by targeting many oncogenes related to proliferation, apoptosis and invasion" molecular function CBC 25032850 hsa-miR-34a The diagnostic role of microRNA-34a in breast cancer: a systematic review and meta-analysis MiR-34a is a promising non-invasive biomarker in diagnosing BC biomarker CBC 28423566 hsa-miR-34a "miR-34a directly targets tRNAiMet?precursors and affects cellular proliferation, cell cycle, and apoptosis" "MiR-34a directly targets tRNAiMet precursors via AGO2-mediated cleavage, and that tRNAiMet functions as an oncogene, potentially representing a target molecule for therapeutic intervention" molecular function CBC 29941603 hsa-miR-34a MicroRNA-34 family in breast cancer: from research to therapeutic potential MiR-34s will open new opportunities for the development of novel therapeutic strategies and define a new approach in identifying potential biomarkers for early diagnosis of breast cancer molecular function CBC 30405848 hsa-miR-34a Evaluation of miRNA-9 and miRNA-34a as potential biomarkers for diagnosis of breast cancer in Iranian women MiR-9 and miR-34a have the capability for distinguishing tumor tissues from healthy tissues and the study of their expression levels in tissue may be used as a biomarker for the diagnosis of breast cancer patients from healthy women biomarker CBC 30468908 hsa-miR-34a MicroRNA 34a suppresses breast cancer cell proliferation and invasion by targeting Notch1 "MiR-34a inhibitor transfection resulted in the opposite effects. In conclusion, the presented data indicated that miR-34a suppressed breast cancer cell proliferation and invasion, and its effect may partly be exerted by targeting Notch1" molecular function CBC 30542388 hsa-miR-34a Overexpression of miR-34a and miR-16 Synergistically Promotes Apoptosis in Breast Cancer Cells MiR-16 or miR-34a induced apoptosis individually molecular function CBC hsa-miR-3622a-5p A novel microRNA regulator of prostate cancer epithelial-esenchymal transition "Here we provide the first direct evidence that miR-3622a-5p (major form of miR-3622a, referred to as miR-3622a) inhibits PCa EMT, progression and metastasis;we found that miR-3622a directly targets EMT effectors ZEB1 and SNAI2;miR-3622a is a novel PCa biomarker and potential drug target for developing therapeutic regimens against advanced PCa" molecular function CBC 28498363 hsa-miR-3622a-5p Aberrantly Expressed Genes and miRNAs in Slow Transit Constipation Based on RNA-Seq Analysis Downregulated expression of hsa-miR-3622a-5p in colon tissue of STC. And adrenoceptor alpha (ADRA1D) was one of target genes of hsa-miR-3622a-5p in STC molecular function CBC 30186855 hsa-miR-3654 Exosome-derived microRNAs contribute to prostate cancer chemoresistance "We found that hub hsa-16-5p, hsa-miR-3915, hsa-miR-488-3p, hsa-miR-5004-5p, hsa-miR-23c, hsa-miR-3673, hsa-miR-3654, and hsa-miR-32-5p were potential targets to hub androgen receptor (AR) and phosphatase and tensin homolog (PTEN)" molecular function CBC 27278879 hsa-miR-3654 In Silico Identification of Human miR 3654 and its Targets Revealed its Involvement in Prostate Cancer Progression MiR-3654 involved in prostate cancer progression using computational approach and hypothesized that the down regulation of miR-3654 could be responsible for a solid tumor to get cancer stem-like cell phenotype molecular function CBC 27297584 hsa-miR-3663-3p "Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases, and benign melanocytic nevi" Hsa-miR-3663-3p and -4281 conversely were found upregulated in malignant melanoma molecular function CBC 23111773 hsa-miR-3663-3p MicroRNA expression profiling in placenta and maternal plasma in early pregnancy loss "The comparison between EPL and control group samples by microarray and RT-qPCR revealed that miR-125a-3p, miR-3663-3p and miR-575 were significantly upregulated in tissue samples" molecular function CBC 29393376 hsa-miR-3667-5p Association of Cigarette Smoking and microRNA Expression in Rectal Cancer: Insight into Tumor Phenotype "Eight of the miRNAs (hsa-miR-139-3p, hsa-miR-3667-5p, hsa-miR-425-3p, hsa-miR-4298, hsa-miR-4429, hsa-miR-4481, hsa-miR-4685-5p, and hsa-miR-4783-3p) increased risk of colorectal cancer death among rectal cancer cases with expression increases in carcinoma tissue, and these miRNAs had higher expression in carcinoma tissue with subjects who smoked more pack-years" molecular function CBC 27780077 hsa-miR-3690 Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma "MiR-3164 and miR-3690 demonstrate no previous connections to cancer, establishing them as potentially fruitful targets for future investigation" molecular function CBC 26472042 hsa-miR-3690 Integrated genomic analysis for prediction of survival for patients with liver cancer using The Cancer Genome Atlas "MiR-3690, miR-561 and miR-621 were independent prognostic factors for the liver cancer patients" biomarker CBC 30065560 hsa-miR-372 Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients The levels of exosomal miR-101 and miR-372 were tumor-specifically increased and higher in breast cancer patients than in healthy women molecular function MFBCE 25333260 hsa-miR-372 Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells Hsa-miR-302b and hsa-miR-372 promote human somatic cell reprogramming molecular function CBC 21490602 hsa-miR-372 miR-372 down-regulates the oncogene ATAD2 to influence hepatocellular carcinoma proliferation and metastasis "MiR-372 suppressed the expression of ATAD2, which was highly expressed in HCC and exerted a proto-oncogene effect in hepatic carcinogenesis" molecular function CBC 24552534 hsa-miR-372 Low mir-372 expression correlates with poor prognosis and tumor metastasis in hepatocellular carcinoma MiR-372 may play an important role in hepatic carcinogenesis and may serve as a new target or method to detect and treat HCC in the future molecular function CBC 25880458 hsa-miR-372 miR-372 suppresses tumour proliferation and invasion by targeting IGF2BP1 in renal cell carcinoma MiR-372 seemed to function as a tumour suppressor in renal cell carcinoma progression by inhibiting the IGF2BP1 expression molecular function CBC 26332146 hsa-miR-372 miR-372 promotes breast cancer cell proliferation by directly targeting LATS2 MiR-372 functions as an oncogenic miRNA in breast cancer by targeting LATS2 molecular function CBC 29456685 hsa-miR-372 MicroRNA expression profile in HER2-positive breast cancer patients submitted to neoadjuvant chemotherapy. "Mir-135b, mir-372 and mir-520h as potential candidates markers for trastuzumab resistance in HER2-positive breast cancer." biomarker CBC hsa-miR-373 Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis Hsa-miR-373 has significantly up-regulated and has been extensively implicated in cancer progression molecular function MFBCE 25446899 hsa-miR-373 Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients "In conclusion, our findings suggest cell-free miR-101 and miR-373 as breast cancer-specific markers" biomarker BBCE 25333260 hsa-miR-373 The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. "MiR-373 and miR-520c stimulated cancer cell migration and invasion in vitro and in vivo, and that certain cancer cell lines depend on endogenous miR-373 activity to migrate efficiently." biomarker CBC 18193036 hsa-miR-373 The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis. "The migration phenotype of miR-373 and miR-520c can be explained by suppression of CD44,significant upregulation of miR-373 in clinical breast cancer metastasis samples that correlated inversely with CD44 expression." molecular function CBC 18193036 hsa-miR-373 The level of circulating miRNA-10b and miRNA-373 in detecting lymph node metastasis of breast cancer: potential biomarkers. Circulating miRNA-10b and miRNA-373 are potential biomarkers for detecting the lymph node status of breast cancer. biomarker CBC 23238818 hsa-miR-373 Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. Serum levels of exosomal miR-373 are linked to triple negative and more aggressive breast carcinomas. biomarker CBC 25333260 hsa-miR-373 Increased serum levels of circulating exosomal microRNA-373 in receptor-negative breast cancer patients. "Overexpression of miR-373 by transfection of MCF-7 cells showed downregulated protein expression of the estrogen receptor, and inhibition of apoptosis induced by camptothecin. Our data indicate that serum levels of exosomal miR-373 are lin" molecular function CBC 25333260 hsa-miR-378d Exosomes from bulk and stem cells from human prostate cancer have a differential microRNA content that contributes cooperatively over local and pre-metastatic niche "Thirteen miRNAs were overexpressed in exosomes from bulk cells: hsa-miR-218-5p, hsa-miR-7-5p, hsa-miR-1290, hsa-miR-17-5p, hsa-miR-20a-5p, hsa-miR-503-5p, hsa-miR-30c-5p, hsa-miR-125b-1, hsa-miR-21-5p, hsa-miR-93-5p, hsa-miR-378c, hsa-miR-378d and hsa-miR-25-3p" molecular function CBC 26675257 hsa-miR-378d Genomic characterization of liver metastases from colorectal cancer patients "In turn, the CLCA4, CA1, SLC4A4, AQP8, and ZG16 mRNAs together with the miR-215, miR-139, miR-133a, miR-378c and miR-378d miRNAs were those genes showing the strongest down-regulated levels across all primary tumor samples analyzed" molecular function CBC 27662660 hsa-miR-378e Identification of microRNA signature and potential pathway targets in prostate cancer The miRNAs 378e and 378i can potentially target homeobox?NKX-3.1?mRNA and inhibit its selective prostate tumor suppressor activity molecular function CBC 27903835 hsa-miR-378e Cancer-associated fibroblasts?release?exosomal?microRNAs that dictate an aggressive phenotype in breast cancer "Breast cancer cells exposed to CAF exosomes containing miR-21, miR-378e, and miR-143, exhibited a significantly increased capacity to promote stemness properties, EMT phenotype, and anchorage-independent cell growth" molecular function CBC 28121625 hsa-miR-378e Exosomal microRNA: a novel biomarker for breast?cancer "MiR-21, miR-378e, miR-143, miR-222, miR-223, miR-16, miR-100, miR-23b, miR-19a and miR-503 from breast stromal cells increased stemness, epithelial-esenchymal transition, brain metastasis, drug resistance, and dormancy and regulated angiogenesis of cancer cells" molecular function CBC 29151358 hsa-miR-382 "Presence of Circulating hsa-miR-145, hsa-miR-155, and hsa-miR-382 in Exosomes Isolated from Serum of Breast Cancer Patients and Healthy Donors" "Our study showed that serum-circulating miR-145, miR-155, and miR-382 are present in exosomes. These miRNAs were previously proposed as noninvasive biomarkers to distinguish between BC patients and healthy individuals" biomarker BBCE 30891102 hsa-miR-382 miR-382 inhibits tumor growth and enhance chemosensitivity in osteosarcoma "A novel functional pathway controlled by miR-382 and its direct targets, KLF12 and HIPK3, that coordinate tumor growth and chemosensitivity, respectively, in OS." molecular function CBC 25344865 hsa-miR-3922-5p Identification of dysregulated microRNAs associated with diagnosis and prognosis in triple?negative breast cancer: An in silico study "A 4 miRNA signature consisting of hsa-miR-148b, hsa-miR-203a, hsa-miR-203b and hsa-miR-3922 was constructed for prediction of prognosis" molecular function CBC 30942465 hsa-miR-3922-5p miR-1915-3p inhibits Bcl-2 expression in the development of gastric cancer "Previous microRNA microarray results suggest that miR-338-5p, miR-1915-3p, miR-3621, miR-3178 and miR-3196 were down-regulated in MKN-45 cells, whereas the expression of miR-3173-3p, miR-3922-5p and miR-609 were up-regulated" molecular function CBC 31036603 hsa-miR-3936 Variation in MicroRNA Expression Profile of Uterine Leiomyoma with Endometrial Cavity Distortion and Endometrial Cavity Non-Distortion "The qRT-PCR results showed that miR-1260b, miR-3936, miR-4267, miR-4638-5p, miR-4695-3p, miR-4734, miR-5096, and miR-8603 were significantly up-regulated in LNG-treated cells" molecular function CBC ?30149651 hsa-miR-3960 MiR-3960 binding sites with mRNA of human genes MiR-3960 has more than 1000mRNA binding sites with high affinity (with ¡÷G/¡÷Gm values greater than or equal to 90%) for 375genes. The miR-3960 has 565 binding sites in the 5'UTRs and 515 sites in theCDS of mRNAs;miR-3960 has binding sites in 73 mRNAs of target genesencoded transcription factors molecular function CBC 25187682 hsa-miR-3960 Runx2/miR-3960/miR-2861 Positive Feedback Loop Is Responsible for Osteogenic Transdifferentiation of Vascular Smooth Muscle Cells Runx2/miR-3960/miR-2861 positive feedback loop plays an important role in osteogenic transdifferentiation of VSMCs and contributes to vascular calcification biomarker CBC 26221600 hsa-miR-3960 Downregulation of long noncoding RNA HOTAIRM1 promotes monocyte/dendritic cell differentiation through competitively binding to endogenous miR-3960 "HOTAIRM1 competitively binds to miR-3960 and finally regulates the process of hematopoiesis, which reveals a novel regulatory mechanism of lncRNA function" biomarker CBC 28280365 hsa-miR-3960 Circulating miRNA panels for specific and early detection in bladder cancer "We found that a combination of 7 miRNA (7-miRNA panel: miR-6087, miR-6724-5p, miR-3960, miR-1343-5p, miR-1185-1-3p, miR-6831-5p and miR-4695-5p) could discriminate bladder cancer from non-cancer and other types of tumors with the highest accuracy" biomarker CBC 30382619 hsa-miR-4261 Tumor heterogeneity in the recurrence of epithelial ovarian cancer demonstrated by polycomb group proteins "MiR-4261 and miR-298 had seed match with ZNF207 3'-UTR and ILF3 3'-UTR, and in turn, ZNF207 and ILF3 are transcription factors of EZH2 promoter, suggesting that miR-4261 and miR-298 might indirectly regulate the expression of EZH2 through intermediate factors" molecular function CBC 25285018 hsa-miR-4261 Therapeutic Suppression of miR-4261 Attenuates Colorectal Cancer by Targeting MCC Inhibition of miR-4261 through targeting of MCC might exert a therapeutic effect for colorectal cancer molecular function CBC 28918036 hsa-miR-4261 "Downregulated MEG3 contributes to tumour progression and poor prognosis in oesophagal squamous cell carcinoma by interacting with miR-4261, downregulating DKK2 and activating the Wnt/¦Â-catenin signalling" "Our study for the first time elaborated the critical role of MEG3-miR-4261-DKK2-Wnt/¦Â-catenin signalling axis in ESCC, and MEG3 could represent a novel diagnostic and prognostic biomarker and therapeutic target in ESCC" molecular function CBC 30990378 hsa-miR-4269 Long noncoding intronic RNAs are differentially expressed in primary and metastatic pancreatic cancer "We found four putative extended EST sequences that show high similarity to seven additional small RNAs: hsa-mir-1259, hsa-mir-326, hsa-mir-4269, hsa-mir-675, SNORD12, SNORD12B and SNORD12C" molecular function CBC 22078386 hsa-miR-4269 TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis The nuclear accumulated TEAD4 and downregulated miR-4269 are proposed to serve as novel prognostic biomarkers in GC biomarker CBC 28759040 hsa-miR-4269 TEAD1/4 exerts oncogenic role and is negatively regulated by miR-4269 in gastric tumorigenesis Downregulation of miR-4269 was associated with poor disease-specific survival and showed a negative correlation with TEAD4 molecular function CBC 28759040 hsa-miR-4269 Targeting BTK through microRNA in chronic lymphocytic leukemia "A set of six miRNAs predicted to target BTK with high specificity by several algorithms (miR-147b, miR-210, miR-425, miR-1253, miR-4269, and miR-4667-3p) substantially decreased BTK expression in Mec2 cell lines derived from CLL patients" molecular function CBC ?27756747 hsa-miR-4271 "When the T minor allele is present in the cell, miR-4271 is able to bind to the 3'UTR of APOC3, and this leads to a decreased translation of APOC3" "When the T minor allele is present in the cell, miR-4271 is able to bind to the 3'-UTR of APOC3, and this leads to a decreased translation of APOC3" molecular function CBC 28381629 hsa-miR-4277 Identification of chemoresistance-associated miRNAs in breast cancer "Expression levels of miR-3617-3p, miR-3136-3p, miR-4277, and miR-92a-1-5p in Bats-72 cell were obviously much higher than the Bcap37 cell, whereas miR-520b was significantly downregulated in the Bats-72 cell?" molecular function CBC 30425571 hsa-miR-4278 SNP rs3202538 in 3'UTR region of ErbB3 regulated by miR-204 and miR-211 promote gastric cancer development in Chinese population "Further genotyping was performed to detect the distribution of allele gene of the SNP in our research, among all this SNPs, rs3202538 which can be potentially regulated by miR-204 miR-211 and miR-4278 were in Hardy-Heinberg equilibrium distribution pattern in the healthy control group (P?