CASP7
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| CASP7 | IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis | 20457620 | This molecular signaling is associated with the activation of signal transducer and activator of transcription 1 and leads to increased mitochondrial membrane permeability; activation of caspase-7 (CASP7), CASP8, and CASP9; and induction of apoptosis but not autophagy. Whereas antiestrogen-resistant cells are capable of inducing autophagy through IFN-mediated signaling, their ability to do so through antiestrogen-regulated signaling is lost | mechanism | BC/OC research |
| CASP7 | Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins | 23562353 | Such pattern might be an indication of hsa-miR-29c miRNA functioning as a repressor of translation of CASP7 within the luminal-A subtype | mechanism | BC/OC research |
| CASP7 | Targeting the XIAP/caspase-7 complex selectively kills caspase-3-deficient malignancies | 23979166 | CASP3/DR combined with p19/p12-CASP7 accumulation correlated with the aggressive evolution of clinical malignancies and a poor prognosis in cancer patients | mechanism | BC/OC research |
| CASP7 | Overexpression of caspase 7 is ERα dependent to affect proliferation and cell growth in breast cancer cells by targeting p21(Cip) | 27089142 | CASP7 is aberrantly expressed in breast cancer and contributes to cell growth and proliferation by downregulating p21(Cip) protein, suggesting that targeting CASP7-positive breast cancer could be one of the potential therapeutic strategies | mechanism | BC/OC research |
| CASP7 | Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers | 30069746 | BCL2 levels are elevated in breast cancer where they are marker of good prognosis. BCL2 and active caspase levels correlate negatively; yet, active caspases indicate good outcome. Low BCL2 and low caspase-7 are highly prognostic of unfavourable outcome across all breast cancers. BCL2 levels indicate molecular subtype and tumour proliferation status in breast cancer | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| CASP7 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation (Homo sapiens) | Wikipathway |
| CASP7 | TNF alpha Signaling Pathway (Homo sapiens) | Wikipathway |
| CASP7 | Allograft Rejection (Homo sapiens) | Wikipathway |
| CASP7 | Parkinsons Disease Pathway (Homo sapiens) | Wikipathway |
| CASP7 | Oncostatin M Signaling Pathway (Homo sapiens) | Wikipathway |
| CASP7 | Nanomaterial induced apoptosis (Homo sapiens) | Wikipathway |
| CASP7 | Integrated Lung Cancer Pathway (Homo sapiens) | Wikipathway |
| CASP7 | Apoptosis (Homo sapiens) | Wikipathway |
| CASP7 | Apoptosis-related network due to altered Notch3 in ovarian cancer (Homo sapiens) | Wikipathway |
| CASP7 | ERK Pathway in Huntington's Disease (Homo sapiens) | Wikipathway |