GPBAR1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| GPBAR1 | Deficiency of G‐protein‐coupled bile acid receptor Gpbar1 (TGR5) enhances chemically induced liver carcinogenesis | 22911633 | TGR5 antagonizes the STAT3 pathway through suppressing STAT3 phosphorylation, its transcription activity, and DNA binding activity, which suggests that TGR5 antagonizes liver tumorigenesis at least in part by inhibiting STAT3 signaling | mechanism | BC/OC research |
| GPBAR1 | Pancreatic acinar cell nuclear factor κB activation because of bile acid exposure is dependent on calcineurin | 23744075 | Acinar cell exposure to bile acids and activation of Gpbar1 cause cell injury mediated by Ca2+?signaling and downstream NF-κB translocation | mechanism | BC/OC research |
| GPBAR1 | TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro | 26420419 | TGR5 is an important mediator of BA-induced cholangiocyte proliferation in vivo and in vitro. Furthermore, TGR5 protects cholangiocytes from death receptor-mediated apoptosis | mechanism | BC/OC research |
| GPBAR1 | Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia | 27510297 | TGR5 functions as a tumor-suppressor in patients with ampullary adenocarcinoma and preoperative hyperbilirubinemia | mechanism | BC/OC research |
| GPBAR1 | The deficiency of G-protein-coupled bile acid receptor Gpbar1 (TGR5) enhances chemically-induced liver carcinogenesis | 22911633 | TGR5 antagonizes STAT3 pathway through suppressing STAT3 phosphorylation, its transcription activity and DNA binding activity, which suggests that TGR5 antagonizes liver tumorigenesis at least in part by inhibiting STAT3 signaling | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| GPBAR1 | R-HSA-373076 | Reactome |
| GPBAR1 | R-HSA-418555 | Reactome |
| GPBAR1 | GPCR downstream signaling (Homo sapiens) | Wikipathway |
| GPBAR1 | GPCR ligand binding (Homo sapiens) | Wikipathway |
| GPBAR1 | Olfactory receptor activity (Homo sapiens) | Wikipathway |