GATA4
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| GATA4 | A Negative Feedback Regulatory Loop Associates the Tyrosine Kinase Receptor ERBB2 and the Transcription Factor GATA4 in Breast Cancer Cells | 19276186 | In agreement with a repressor role of GATA4 on ERBB2 gene expression balanced by ERBB2 activation of the GATA4 gene, a negative correlation between the relative levels of ERBB2 and GATA4 mRNA was observed in breast cancer cell lines and breast tumor samples | mechanism | BC/OC research |
| GATA4 | GATA4 promotes hepatoblastoma cell proliferation by altering expression of miR125b and DKK3 | 27788486 | GATA4 is therefore a potential therapeutic target or biomarker for progression in HB patients | biomarker | BC/OC research |
| GATA4 | GATA4 promotes hepatoblastoma cell proliferation by altering expression of miR125b and DKK3 | 27788486 | GATA4/miR125b/DKK3 axis may be a major regulator of growth, migration, invasion, and survival in hepatoma cells | mechanism | BC/OC research |
| GATA4 | GATA4 loss of function in liver cancer impedes precursor to hepatocyte transition | 28758902 | Thus, disruption of GATA4-mediated transactivation in HCC suppresses hepatocyte epithelial differentiation to sustain replicative precursor phenotype | mechanism | BC/OC research |
| GATA4 | GATA4 inhibits cell differentiation and proliferation in pancreatic cancer | 30142155 | GATA4 gene might play a role in cell proliferation and differentiation during the progression of pancreatic cancer | mechanism | BC/OC research |
| GATA4 | Restoration of GATA4 expression impedes breast cancer progression by transcriptional repression of ReLA and inhibition of NF-κB signaling | 30187949 | GATA4 is a potential prognostic biomarker and gene therapeutic target for human BrCa | biomarker | BC/OC research |
| GATA4 | Restoration of GATA4 expression impedes breast cancer progression by transcriptional repression of ReLA and inhibition of NF-κB signaling | 30187949 | GATA4 plays a tumor-suppressive role via repression of NF-κB signaling in BrCa cells | mechanism | BC/OC research |
| GATA4 | GATA4 is upregulated in nasopharyngeal cancer and facilitates epithelial-mesenchymal transition and metastasis through regulation of?SLUG | 30542490 | GATA4 acts as an oncogene and serves crucial roles in NPC and GATA4 may find a potential application as therapeutic option in NPC | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| GATA4 | Factors involved in megakaryocyte development and platelet production (Homo sapiens) | Wikipathway |
| GATA4 | Serotonin Receptor 2 and ELK-SRF/GATA4 signaling (Homo sapiens) | Wikipathway |
| GATA4 | Extracellular vesicles in the crosstalk of cardiac cells (Homo sapiens) | Wikipathway |
| GATA4 | Cardiac conduction (Homo sapiens) | Wikipathway |
| GATA4 | Endoderm Differentiation (Homo sapiens) | Wikipathway |
| GATA4 | YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens) | Wikipathway |
| GATA4 | Incretin synthesis, secretion, and inactivation (Homo sapiens) | Wikipathway |
| GATA4 | Cardiac Progenitor Differentiation (Homo sapiens) | Wikipathway |
| GATA4 | Adipogenesis (Homo sapiens) | Wikipathway |
| GATA4 | R-HSA-2032785 | Reactome |