CTSB
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| CTSB | Cathepsin B: a potential prognostic marker for inflammatory breast cancer | 21199580 | CTSB may initiate proteolytic pathways crucial for IBC invasion. Thus, our data demonstrate that CTSB may be a potential prognostic marker for lymph node metastasis in IBC | mechanism | BC/OC research |
| CTSB | Hormonal-receptor positive breast cancer: IL-6 augments invasion and lymph node metastasis via stimulating cathepsin B expression | 27482469 | IL-6-induced CTSB may play a role in lymph node metastasis, and that may possess future therapeutic implications for HRP-breast cancer patients with pLNs | mechanism | BC/OC research |
| CTSB | TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA | 29018571 | SAHA may stimulate TRAIL DR5-CTSB crosstalk, influence the activity of downstream TOR signalling pathway mainly through the AKTs pathway, and initiate the autophagy of breast cancer cells | mechanism | BC/OC research |
| CTSB | Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression | 29187882 | TgCTSB and tgCTSL both display a strong and distinct impact on proteome composition of lung macrometastases in the PyMT model | mechanism | BC/OC research |
| CTSB | Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice | 20133781 | Double deficiency of Ctsb and Ctsz exerts significant synergistic anticancer effects, whereas the single deficiencies demonstrate at least partial reciprocal compensation | mechanism | BC/OC research |
| CTSB | ErbB2-Driven Breast Cancer Cell Invasion Depends on a Complex Signaling Network Activating Myeloid Zinc Finger-1-Dependent Cathepsin B Expression | 22464443 | The identified signaling network activates the transcription of cathepsin B gene (CTSB) via myeloid zinc finger-1 transcription factor that binds to an ErbB2-responsive enhancer element in the first?intron?of?CTSB | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| CTSB | R-HSA-2132295 | Reactome |
| CTSB | hsa04142:Lysosome | KEGG |
| CTSB | hsa04612:Antigen processing and presentation | KEGG |
| CTSB | hsa04924:Renin secretion | KEGG |
| CTSB | MHC class II antigen presentation (Homo sapiens) | Wikipathway |
| CTSB | Collagen degradation (Homo sapiens) | Wikipathway |
| CTSB | Assembly of collagen fibrils and other multimeric structures (Homo sapiens) | Wikipathway |
| CTSB | Neutrophil degranulation (Homo sapiens) | Wikipathway |
| CTSB | Ebola Virus Pathway on Host (Homo sapiens) | Wikipathway |
| CTSB | R-HSA-1442490 | Reactome |