CUL4A
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| CUL4A | A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors | 19056892 | CUL4A and CUL4B are therefore components of a conserved Wnt-induced proteasome targeting (WIPT) complex that regulates p27KIP1 levels and cell cycle progression in mammalian cells. | mechanism | BC/OC research |
| CUL4A | Analysis of DNA Repair–Related Genes in Breast Cancer Reveals?CUL4A?Ubiquitin Ligase as a Novel Biomarker of Trabectedin Response | 23364677 | Our observations support the notion of greater trabectedin activity in tumors exhibiting BRCAness and reveal CUL4A as a potential biomarker for definition of trabectedin target patients | biomarker | BC/OC research |
| CUL4A | CUL4A?contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response | 24870930 | In particular, we report a putative role of CUL4A in bypassing the immune system in breast cancer through the down-regulation of several molecules involved in the immune surveillance. These findings provide insight into the oncogenic properties of CUL4A in basal-like breast cancer and highlight the therapeutic opportunities to target CUL4A | mechanism | BC/OC research |
| CUL4A | Dysregulation of CUL4A and CUL4B Ubiquitin Ligases in Lung Cancer | 27974468 | CUL4A and CUL4B are differentially associated with etiologic factors for pulmonary malignancies and are independent prognostic markers for the survival of distinct lung cancer subtypes | biomarker | BC/OC research |
| CUL4A | CUL4A overexpression as an independent adverse prognosticator in intrahepatic cholangiocarcinoma | 28576144 | Overexpression of CUL4A plays an oncogenic role in iCCA and adversely affects disease-free survival. Thus, it may prove to be a powerful prognostic factor and a potential therapeutic target | mechanism | BC/OC research |
| CUL4A | miR-377 targets CUL4A and regulates metastatic capability in ovarian cancer | 29512715 | MiR-377 is a significant negative regulator of CUL4A that controls cancer cell progression in ovarian cancer cell lines | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| CUL4A | R-HSA-110314 | Reactome |
| CUL4A | R-HSA-5696394 | Reactome |
| CUL4A | R-HSA-5696395 | Reactome |
| CUL4A | R-HSA-5696400 | Reactome |
| CUL4A | R-HSA-6781823 | Reactome |
| CUL4A | R-HSA-6781827 | Reactome |
| CUL4A | R-HSA-6782135 | Reactome |
| CUL4A | R-HSA-6782210 | Reactome |
| CUL4A | hsa03420:Nucleotide excision repair | KEGG |
| CUL4A | hsa04120:Ubiquitin mediated proteolysis | KEGG |