RANBP1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| RANBP1 | Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta | 8995296 | RanBP1 and karyopherin β interact with distinct sites of Ran and suggest that RanBP1 plays an essential role in nuclear transport by permitting RanGAP-mediated hydrolysis of GTP on Ran complexed to karyopherin β | mechanism | BC/OC research |
| RANBP1 | RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells | 17940066 | RANBP1 activity is required for the proper localization of specific factors that regulate microtubule function; loss of this activity contributes to the generation of aneuploidy in a microtubule-dependent manner | mechanism | BC/OC research |
| RANBP1 | RanBP1 downregulation sensitizes cancer cells to taxol in a caspase-3-dependent manner | 19270727 | RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent | mechanism | BC/OC research |
| RANBP1 | Sgk1 enhances RANBP1 transcript levels and decreases taxol sensitivity in RKO colon carcinoma cells | 23108393 | SGK1 also affects mitotic stability in colon carcinoma cells by regulating the expression of RANBP1 (Ran-specific binding protein 1), the pivotal regulator of GTPase RAN. SGK1 modulates RAN/RANBP1 abundance at the transcriptional level via SP1 activation and phosphorylation on Serine 59, thus affecting taxol sensitivity in these cells? | mechanism | BC/OC research |
| RANBP1 | Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals | 31021318 | The key feature for the two mechanistic changes from fungi to animals was the loss of affinity between RanBP1-RanGTP and CRM1, since residues mediating their interaction in fungi were not conserved in animals | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| RANBP1 | Host Interactions of HIV factors (Homo sapiens) | Wikipathway |
| RANBP1 | R-HSA-165054 | Reactome |
| RANBP1 | hsa05166:HTLV-I infection | KEGG |
| RANBP1 | hsa05203:Viral carcinogenesis | KEGG |
| RANBP1 | HIV Life Cycle (Homo sapiens) | Wikipathway |