SFN
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| SFN | Quantitative assessment of promoter hypermethylation during breast cancer development | 11839581 | For RASSF1A and 14-3-3 promoter methylation was demonstrated in epithelial hyperplasia and intraductal papillomas. | mechanism | BC/OC research |
| SFN | Unraveling breast cancer heterogeneity through transcriptomic and epigenomic analysis | 19452229 | SFN (stratifin), a TSG involved in cell-cycle control and regulated by TP53, is frequently epigenetically silenced in breast cancer.Similar to RASSF1A, SFN methylation frequently occurs in microdissected atypical hyperplasia and DCIS. SFN methylation, however, has also been scored in physiological breast proliferations and stromal breast tissue, emphasizing the importance of selective tissue sampling when using SFN methylation as a biomarker of breast cancer risk | biomarker | BC/OC research |
| SFN | Hypermethylated 14-3-3-sigma and ESR1 gene promoters in serum as candidate biomarkers for the diagnosis and treatment efficacy of breast cancer metastasis | 20487521 | The relationship of 14-3-3-sigma with breast cancer metastasis and progression found in this study suggests a possible application of 14-3-3-sigma as a biomarker to screen for metastasis and to follow up patients treated for metastatic breast cancer, monitoring their disease status and treatment response | biomarker | BC/OC research |
| SFN | Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer | 11423985 | The 14-3-3 proteins are a family of widely expressed regulatory molecules. Their ability to bind a variety of functionally diverse signaling proteins, including kinases, phosphatases, and transmembrane receptors, allows 14-3-3 proteins to play important roles in a wide range of regulatory processes, such as mitogenic signal transduction, cell cycle control, and apoptotic cell death. | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| SFN | Cell Cycle Checkpoints (Homo sapiens) | Wikipathway |
| SFN | DNA Damage Response (Homo sapiens) | Wikipathway |
| SFN | Calcium Regulation in the Cardiac Cell (Homo sapiens) | Wikipathway |
| SFN | TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens) | Wikipathway |
| SFN | RHO GTPases activate PKNs (Homo sapiens) | Wikipathway |
| SFN | TP53 Regulates Metabolic Genes (Homo sapiens) | Wikipathway |
| SFN | Myometrial Relaxation and Contraction Pathways (Homo sapiens) | Wikipathway |
| SFN | Translocation of GLUT4 to the plasma membrane (Homo sapiens) | Wikipathway |
| SFN | Intrinsic Pathway for Apoptosis (Homo sapiens) | Wikipathway |
| SFN | Cell Cycle (Homo sapiens) | Wikipathway |