FGFR2
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
Gene symble | Title | PMID | Curated descirption | Category | Literature category |
---|---|---|---|---|---|
FGFR2 | The Breast Cancer Susceptibility Gene Product Fibroblast Growth Factor Receptor 2 Serves as a Scaffold for Regulation of NF-κB Signaling | 22988296 | FGFR2 serves as a scaffold for multiple components of the NF-κB signaling complex | mechanism | BC/OC research |
FGFR2 | Activating somatic FGFR2 mutations in breast cancer | 23527311 | Somatic breast cancer mutations in FGFR2 providing evidence for the activating nature of FGFR2-mediated signalling in the pathogenesis of breast cancer | mechanism | BC/OC research |
FGFR2 | Master regulators of FGFR2 signalling and breast cancer risk | 24043118 | Fibroblast growth factor receptor 2 signalling has an important role in mediating breast cancer risk | mechanism | BC/OC research |
FGFR2 | FGFR2 amplification in metastatic hormone-positive breast cancer and response to an mTOR inhibitor | 28430863 | GFR2 amplification to treatment with nab-paclitaxel and an mTOR inhibitor, whilst showing no significant benefit from endocrine therapy or treatment with a CDK4/6 inhibitor | mechanism | BC/OC research |
FGFR2 | FGFR2 risk SNPs confer breast cancer risk by augmenting oestrogen responsiveness | 27236187 | FGFR2 can confer increased breast cancer risk that is consistent with oestrogen exposure as a major driver of breast cancer risk | mechanism | BC/OC research |
FGFR2 | Association of FGFR2 and TOX3 Genetic Variants With the Risk of Breast Cancer in Iranian Women | Link | Genetic variants of FGFR2 (rs1219648 AG) and TOX3 (rs8051542 TC) can be potential candidate biomarkers for breast cancer risk | biomarker | BC/OC research |
FGFR2 | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential | 29115712 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | mechanism | BCEXO research |
Survival analysis
Pathway
Pathway Term | Reference DB | |
---|---|---|
FGFR2 | hsa04151:PI3K-Akt signaling pathway | KEGG |
FGFR2 | R-HSA-5673001 | Reactome |
FGFR2 | hsa04010:MAPK signaling pathway | KEGG |
FGFR2 | hsa04014:Ras signaling pathway | KEGG |
FGFR2 | hsa04015:Rap1 signaling pathway | KEGG |
FGFR2 | hsa04144:Endocytosis | KEGG |
FGFR2 | hsa05200:Pathways in cancer | KEGG |
FGFR2 | hsa05230:Central carbon metabolism in cancer | KEGG |
FGFR2 | hsa05215:Prostate cancer | KEGG |
FGFR2 | R-HSA-5655253 | Reactome |