PSMD2
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| PSMD2 | PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation | 29777785 | Upregulated PSMD2 is a valuable predictor for clinical outcomes in BC and may have an essential role in BC tumorigenesis. | biomarker | BC/OC research |
| PSMD2 | PSMD2 regulates breast cancer cell proliferation and cell cycle progression by modulating p21 and p27 proteasomal degradation | 29777785 | Transcriptome signatures involving proliferation, cell cycle, and apoptosis were critically enriched in specimens with elevated PSMD2. Consistently, PSMD2 knockdown inhibited cell proliferation and arrested cell cycle at G0/G1 phase in vitro, as well as suppressed tumor growth in vivo.The cell cycle arrest caused by silencing PSMD2 partially resulted from increased p21 and/or p27. Mechanically, PSMD2 physically interacted with p21 and p27 and mediated their ubiquitin-proteasome degradation with the cooperation of USP14. | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| PSMD2 | hsa03050:Proteasome | KEGG |
| PSMD2 | Parkin-Ubiquitin Proteasomal System pathway (Homo sapiens) | Wikipathway |
| PSMD2 | TNF alpha Signaling Pathway (Homo sapiens) | Wikipathway |
| PSMD2 | Regulation of DNA replication (Homo sapiens) | Wikipathway |
| PSMD2 | Regulation of Apoptosis (Homo sapiens) | Wikipathway |
| PSMD2 | Interleukin-1 family signaling (Homo sapiens) | Wikipathway |
| PSMD2 | Proteasome Degradation (Homo sapiens) | Wikipathway |
| PSMD2 | ABC-family proteins mediated transport (Homo sapiens) | Wikipathway |
| PSMD2 | hsa05169:Epstein-Barr virus infection | KEGG |
| PSMD2 | R-HSA-68827 | Reactome |