FTH1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| FTH1 | Ferritin binds and activates p53 under oxidative stress | 19716362 | Our findings show that ferroxidase activity is not required for FTH1 to increase p53 transcriptional activity | mechanism | BC/OC research |
| FTH1 | Ferritin heavy chain in triple negative breast cancer: a favorable prognostic marker that relates to a cluster of differentiation 8 positive (CD8+) effector T-cell response | 24742827 | Our data provide evidence toward new immune regulatory properties of FTH1 in TNBC, which may facilitate development of novel therapeutic targets | mechanism | BC/OC research |
| FTH1 | Regulation of iron homeostasis by the p53-ISCU pathway | 26560363 | In response to DNA damage, p53 induced FTH1 and suppressed transferrin receptor, which regulates iron entry into cells. HCT116 p53+/+ cells were resistant to iron accumulation, but HCT116 p53 / cells accumulated intracellular iron after DNA damage | mechanism | BC/OC research |
| FTH1 | Decreased Iron in Cancer Cells and Their Microenvironment Improves Cytolysis of Breast Cancer Cells by Natural Killer Cells | 28476795 | Real time quantitative polymerase chain reaction showed that iron up-regulated the expression of FTH1 and iron chelator DFOM reduced FTH1 expression of MCF-7 and MDA-MB-231 cells | mechanism | BC/OC research |
| FTH1 | A FTH1 gene:pseudogene:microRNA network regulates tumorigenesis in prostate cancer | 29240947 | ?In this study, we utilize an unbiased screen to identify the ferritin heavy chain 1 (FTH1) transcript and multiple FTH1 pseudogenes as targets of several oncogenic miRNAs in prostate cancer (PCa). We characterize the critical role of this FTH1 gene:pseudogene:miRNA network in regulating tumorigenesis in PCa, whereby oncogenic miRNAs downregulate the expression of FTH1 and its pseudogenes to drive oncogenesis | mechanism | BC/OC research |
| FTH1 | Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing | 24255815 | FTH1 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| FTH1 | R-HSA-3000480 | Reactome |
| FTH1 | R-HSA-432722 | Reactome |
| FTH1 | R-HSA-917937 | Reactome |
| FTH1 | hsa04978:Mineral absorption | KEGG |
| FTH1 | Iron uptake and transport (Homo sapiens) | Wikipathway |
| FTH1 | Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens) | Wikipathway |
| FTH1 | Nuclear Receptors Meta-Pathway (Homo sapiens) | Wikipathway |
| FTH1 | NRF2 pathway (Homo sapiens) | Wikipathway |
| FTH1 | trans-Golgi Network Vesicle Budding (Homo sapiens) | Wikipathway |
| FTH1 | Neutrophil degranulation (Homo sapiens) | Wikipathway |