TYR
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| TYR | Loss of tyrosinase activity confers increased skin tumor susceptibility in mice | 15007389 | In vitro mechanistic studies demonstrated that transfection of the Tyr(Cys) allele in a human squamous cell carcinoma cell line (NCI-H520) increases tyrosinase enzyme activity and confers resistance to hydrogen peroxide-induced oxidative DNA damage | mechanism | BC/OC research |
| TYR | MC1R, SLC45A2 and TYR genetic variants involved in melanoma susceptibility in southern European populations: results from a meta-analysis | 22464347 | Adjustment for all clinical potential confounders showed that melanoma risks attributable to MC1R and SLC45A2 variants strongly persisted (OR: 2.01 95% CI: 1.49-2.72 and OR: 0.50, 95% CI: 0.31-0.80, respectively), while the association of TYR p.Arg402Gln was no longer significant | mechanism | BC/OC research |
| TYR | Tyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging | 23508226 | In vivo PAI/MRI/PET imaging studies showed that MCF-7-TYR tumors achieved significant higher signals and tumor-to-background contrasts than those of MCF-7 tumor. Our study demonstrates that TYR gene can be utilized as a multifunctional reporter gene for PAI/MRI/PET both?in vitro?and?in vivo | mechanism | BC/OC research |
| TYR | The tetrapeptide Arg-Leu-Tyr-Glu inhibits VEGF-induced angiogenesis | 26051280 | Arg-Leu-Tyr-Glu (RLYE) effectively inhibited vascular endothelial growth factor (VEGF)-induced endothelial cell proliferation, migration and tube formation, with an IC50 of 0.06-0.08?nM, which was about ten-fold lower than that of the control peptide KLYD (0.79?nM), as well as suppressed developmental angiogenesis in a zebrafish model | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| TYR | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism (Homo sapiens) | Wikipathway |
| TYR | TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer (Homo sapiens) | Wikipathway |
| TYR | Mitochondrial translation (Homo sapiens) | Wikipathway |
| TYR | Melanin biosynthesis (Homo sapiens) | Wikipathway |
| TYR | Amine-derived hormones (Homo sapiens) | Wikipathway |
| TYR | tRNA modification in the nucleus and cytosol (Homo sapiens) | Wikipathway |
| TYR | Phase I - Functionalization of compounds (Homo sapiens) | Wikipathway |
| TYR | Biocrates Metabolites Overview (Homo sapiens) | Wikipathway |
| TYR | Biosynthesis and regeneration of tetrahydrobiopterin (BH4) and catabolism of phenylalanine, including diseases (Homo sapiens) | Wikipathway |
| TYR | S Phase (Homo sapiens) | Wikipathway |