TRPC5
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| TRPC5 | Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells | 22988121 | In an athymic nude mouse model of adriamycin-resistant human breast tumor, suppressing TRPC5 decreased the growth of tumor xenografts. Nuclear factor of activated T cells isoform c3 (NFATc3) was the transcriptional factor that links the TRPC5 activity to P-gp production | mechanism | BC/OC research |
| TRPC5 | Essential role for TrpC5-containing extracellular vesicles in breast cancer with chemotherapeutic resistance | 24733904 | TrpC5-containing circulating EVs may transfer chemoresistance property to nonchemoresistant recipient cells | mechanism | BC/OC research |
| TRPC5 | A Methylation-Based Regulatory Network for MicroRNA 320a in Chemoresistant Breast Cancer | 25159093 | MiR-320a is a mediator of chemoresistance by targeting TRPC5 and NFATC3. Expression of miR-320a is regulated by methylation of its promoter and that of ETS-1 | mechanism | BC/OC research |
| TRPC5 | TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway | 28600513 | A novel role of TRPC5 as an inducer of autophagy, and this suggests a novel mechanism of drug resistance in chemotherapy for breast cancer | mechanism | BC/OC research |
| TRPC5 | Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer | 29463225 | We demonstrated the essential role of glycolysis in TRPC5 induced chemoresistance in human CRC cells via maintaining [Ca2+]?i?homeostasis | mechanism | BC/OC research |
| TRPC5 | Increasing circulating exosomes carrying TRPC5 predicts chemoresistance in metastatic breast cancer patients | 28032400 | CirExo-TRPC5 might act as a noninvasive chemoresistance marker and might serve as an adjuvant to the current imaging examination-based chemoresistance | biomarker | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| TRPC5 | R-HSA-3295583 | Reactome |
| TRPC5 | R-HSA-3295583 | Reactome |
| TRPC5 | R-HSA-418890 | Reactome |
| TRPC5 | R-HSA-418890 | Reactome |
| TRPC5 | Netrin-1 signaling (Homo sapiens) | Wikipathway |
| TRPC5 | Ion channel transport (Homo sapiens) | Wikipathway |