UCHL1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| UCHL1 | The Ubiquitin Peptidase UCHL1 Induces G0/G1 Cell Cycle Arrest and Apoptosis Through Stabilizing p53 and Is Frequently Silenced in Breast Cancer | 22279545 | UCHL1 exerts its tumor suppressive functions by inducing G0/G1cell cycle arrest and apoptosis in breast tumorigenesis, requiring its deubiquitinase activity. Its frequent silencing by promoter CpG methylation may serve as a potential tumor marker for breast cancer | mechanism | BC/OC research |
| UCHL1 | Differential expression of ubiquitin carboxy-terminal hydrolase L1 in breast carcinoma and its biological significance | 23664488 | The high expression of UCHL1 in metaplastic carcinomas of the breast, which is pathogenically related to epithelial-mesenchymal transition, may implicate an association between UCHL1 expression and the epithelial-mesenchymal transition in breast cancer | mechanism | BC/OC research |
| UCHL1 | UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α | 25615526 | UCHL1 promotes metastases as a deubiquitinating enzyme for HIF-1α, which justifies exploiting it as a prognostic marker and therapeutic target of cancers | mechanism | BC/OC research |
| UCHL1 | UCH-L1 promotes invasion of breast cancer cells through activating Akt signaling pathway | 28636190 | UCH-L1 promotes invasion of breast cancer cells and might serve as a potential therapeutic target for treatment of human patients with breast cancers | mechanism | BC/OC research |
| UCHL1 | UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization | 28761052 | Cancer cells acquire antioxidant and radioresistant phenotypes through UCHL1-HIF-1-mediated metabolic reprogramming including the activation of PPP and provide a rational basis for targeting this gene network for radiosensitization | mechanism | BC/OC research |
| UCHL1 | UCHL1 containing exosomes mediate chemotherapeutic resistance transfer in breast cancer | 28334432 | UCH-L1-containing exosomes can transfer chemoresistance to recipient cells and these exosomes may be useful as non-invasive diagnostic biomarkers for detection of chemoresitance in breast cancer patients, achieving more effective and individualized chemotherapy | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| UCHL1 | hsa05012:Parkinson's disease | KEGG |