S1PR2
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| S1PR2 | Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 — Jekyll Hidden behind Hyde | 21984966 | S1PR2 expressed in host endothelial cells and tumor-infiltrating myeloid cells in concert mediates potent inhibition of tumor angiogenesis and tumor growth?in vivo, with inhibition of VEGF expression and MMP9 activity | mechanism | BC/OC research |
| S1PR2 | Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis | 22707406 | Local tumour growth is regulated by both S1P from the tumour and systemic S1P, whereas lung colonization and metastasis is selectively controlled via systemic S1P and downregulation of breast cancer metastasis suppressor 1 (BRMS1; a master suppressor of metastasis) through S1PR2 signalling | mechanism | BC/OC research |
| S1PR2 | The tumor suppressive TGF-β/SMAD1/S1PR2 signaling axis is recurrently inactivated in diffuse large B-cell lymphoma | 29615404 | Uncover an important novel tumor suppressive function of the TGF-β/TGF-βR2/SMAD1/S1PR2 axis in DLBCL, and show that DLBCL cells have evolved to inactivate the pathway at the level of SMAD1 expression | mechanism | BC/OC research |
| S1PR2 | The sphingosine 1-phosphate receptor 2 is shed in exosomes from breast cancer cells and is N-terminally processed to a short constitutively active form that promotes extracellular signal regulated kinase activation and DNA synthesis in fibroblasts. | 30034630 | S1P2 is released from breast cancer cells in exosomes and is processed by fibroblasts to promote ERK signaling and proliferation of breast cancer cells | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| S1PR2 | R-HSA-418594 | Reactome |
| S1PR2 | R-HSA-419408 | Reactome |
| S1PR2 | hsa04071:Sphingolipid signaling pathway | KEGG |
| S1PR2 | hsa04080:Neuroactive ligand-receptor interaction | KEGG |