FTL
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| FTL | Validation of tumor-associated macrophage ferritin light chain as a prognostic biomarker in node-negative breast cancer tumors: A multicentric 2004 national PHRC study | 21898387 | The validation of FTL as a breast tumor prognostic biomarker in node-negative patients, and second, the fact that FTL is stored in TAM | biomarker | BC/OC research |
| FTL | Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin | 23969999 | The increased levels of FTL in breast cancer indicate that FTL may be used as a diagnostic and prognostic marker for breast cancer | biomarker | BC/OC research |
| FTL | Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin | 23969999 | Targeted downregulation of FTL protein by the microRNA miR-133a increases sensitivity of MCF-7/DOX and MCF-7/CDDP cells to doxorubicin and cisplatin | mechanism | BC/OC research |
| FTL | Ferritin Heavy Chain in Triple Negative Breast Cancer: A Favorable Prognostic Marker that Relates to a Cluster of Differentiation 8 Positive (CD8+) Effector T-cell Response | 24742827 | We observed that protein expression of FTH1 was significantly higher in good prognostic patients (n = 82) than those with poor prognosis (n = 44) (p = 0.001), whereas neither expression of FTL (p = 0.054) nor FTH1/FTL ratio (p = 0.566) showed significant difference between patients with different clinical outcome | biomarker | BC/OC research |
| FTL | Expression of Ferritin Light Chain (FTL) Is Elevated in Glioblastoma, and FTL Silencing Inhibits Glioblastoma Cell Proliferation via the GADD45/JNK Pathway | 26871431 | FTL regulates the growth of GBM cells via the GADD45/JNK pathway | mechanism | BC/OC research |
| FTL | Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing | 24255815 | FTL distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| FTL | R-HSA-3000480 | Reactome |
| FTL | R-HSA-432722 | Reactome |
| FTL | R-HSA-917937 | Reactome |
| FTL | hsa04978:Mineral absorption | KEGG |
| FTL | Iron uptake and transport (Homo sapiens) | Wikipathway |
| FTL | Binding and Uptake of Ligands by Scavenger Receptors (Homo sapiens) | Wikipathway |
| FTL | Nuclear Receptors Meta-Pathway (Homo sapiens) | Wikipathway |
| FTL | NRF2 pathway (Homo sapiens) | Wikipathway |
| FTL | trans-Golgi Network Vesicle Budding (Homo sapiens) | Wikipathway |
| FTL | Neutrophil degranulation (Homo sapiens) | Wikipathway |