hsa-miR-27a
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| hsa-miR-27a | MiR-27 as a prognostic marker for breast cancer progression and patient survival. | 23240057 | High miR-27a expression is associated with poor overall survival in patients with breast cancer, which suggests that miR-27a could be a valuable marker of breast cancer progression. | biomarker | BC/OC research |
| hsa-miR-27a | microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. | 24401318 | MiR-27a and miR-27b expression may be pharmacologically relevant modulators of DPD enzyme function in the liver. | biomarker | BC/OC research |
| hsa-miR-27a | microRNAs miR-27a and miR-27b directly regulate liver dihydropyrimidine dehydrogenase expression through two conserved binding sites. | 24401318 | Increased accumulation of RNA-induced silencing complex (RISC) proteins on DPYD mRNA in cells overexpressing the highly homologous microRNAs (miRNA) miR-27a and miR-27b. These miRNAs were shown to repress DPD expression through two conserved recognition sites in DPYD. | mechanism | BC/OC research |
| hsa-miR-27a | MicroRNA-27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. | 29115608 | MiR-27a exhibits an essential role in tumor development and progression in TNBC and may be used as a potential biomarker to predict radiotherapy response and prognosis for the disease. | biomarker | BC/OC research |
| hsa-miR-27a | MicroRNA-27a promotes tumorigenesis via targeting AKT in triple negative breast cancer. | 29115608 | MiR-27a inhibited radiation induced apoptosis in TNBC cells by regulation of caspase 3/7 and Bcl?2 expression. Furthermore, the expression levels of PTEN and phosphorylated protein kinase B in MDA?MB?231 and MDA?MB?468 cells was altered following overexpression of miR?27a. The luciferase assay demonstrated that miR?27a regulated PTEN and BAX expression by binding to 3'?untranslated regions. | mechanism | BC/OC research |
| hsa-miR-27a | miR-27a promotes human breast cancer cell migration by inducing EMT in a FBXW7-dependent manner | 30365154 | The important function of miR-27a in regulating the metastasis of breast cancer in a FBXW7-dependent manner, and provide evidence for the potential application of miR-27a in breast cancer therapy. | biomarker | BC/OC research |
| hsa-miR-27a | miR-27a promotes human breast cancer cell migration by inducing EMT in a FBXW7-dependent manner | 30365154 | Overexpression of miR-27a resulted in enhanced cell migration by inducing epithelial-to-mesenchymal transition, while its knockdown effectively reversed these cellular events.F-box and WD repeat domain containing 7 (FBXW7) is a downstream target gene of miR-27a in human breast cancer cells.the ectopic expression of FBXW7 may effectively suppress the epithelial-to-mesenchymal transition and migratory activity of breast cancer cells, in addition to reversing the cell migration mediated by miR-27a. | mechanism | BC/OC research |
| hsa-miR-27a | Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis | 25446899 | Hsa-miR-27a has significantly up-regulated and has been extensively implicated in cancer progression | mechanism | BCEXO research |
Survival analysis
Pathways
| Enriched Terms | Cross Refer. |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | KEGG |
| Sphingolipid signaling pathway | KEGG |
| Non-small cell lung cancer | KEGG |
| Axon guidance | KEGG |
| p53 signaling pathway | KEGG |
| Transcriptional misregulation in cancer | KEGG |
| Focal adhesion | KEGG |
| Shigellosis | KEGG |
| Prostate cancer | KEGG |
| Ubiquitin mediated proteolysis | KEGG |