ENPP1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| ENPP1 | Enpp1: A Potential Facilitator of Breast Cancer Bone Metastasis | 23861746 | By both routes of administration, increased expression of Enpp1 enhanced the ability of MDA-MB-231 cells to form tumors in the bone relative to cells expressing vector alone, as determined by digital radiography and histological analysis；these data suggest a potential role for Enpp1 in the development of breast cancer bone metastasis | mechanism | BC/OC research |
| ENPP1 | Identification of Gene Expression Signature in Estrogen Receptor Positive Breast Carcinoma | 24179381 | Significant over-expression of all the six genes in ERα (+) breast tumors as compared to ERα (-) breast tumors. In vitro studies using T-47D breast cancer cell line confirmed the estrogen dependant expression of four of the above six genes (SLC7A8, ENPP1, LAMB2, and PLAT) | mechanism | BC/OC research |
| ENPP1 | Functional characterization of ENPP1 reveals a link between cell cycle progression and stem-like phenotype in glioblastoma | 27308351 | A high-throughput phenotypic screen in glioblastoma stem-like cells (GSCs) identified a novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state | mechanism | BC/OC research |
| ENPP1 | 27308351 | A novel molecular mechanism in which ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) plays an important role in balancing the pool of nucleotides, thus maintaining GSCs in an undifferentiated proliferative state | mechanism | BC/OC research | |
| ENPP1 | Development of an ENPP1 Fluorescence Probe for Inhibitor Screening, Cellular Imaging, and Prognostic Assessment of Malignant Breast Cancer | 31536342 | ENPP1 mRNA expression in tissue samples from patients with triple-negative breast cancer was significantly inversely related to recurrence-free survival (RFS) and overall survival (OS) | biomarker | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| ENPP1 | R-HSA-196843 | Reactome |
| ENPP1 | hsa00230:Purine metabolism | KEGG |
| ENPP1 | hsa00500:Starch and sucrose metabolism | KEGG |
| ENPP1 | hsa00760:Nicotinate and nicotinamide metabolism | KEGG |
| ENPP1 | hsa00770:Pantothenate and CoA biosynthesis | KEGG |
| ENPP1 | hsa01100:Metabolic pathways | KEGG |
| ENPP1 | Metabolism of water-soluble vitamins and cofactors (Homo sapiens) | Wikipathway |
| ENPP1 | Pyrimidine metabolism (Homo sapiens) | Wikipathway |
| ENPP1 | Insulin Signaling (Homo sapiens) | Wikipathway |