CYP19A1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| CYP19A1 | Positive Association of Polymorphisms in Estrogen Biosynthesis Gene, CYP19A1, and Metabolism, GST, in Breast Cancer Susceptibility | 22300440 | The effect of CYP19A1 T/C polymorphism in susceptibility to breast cancer development can be modulated by the presence of GSTM1 and GSTT1, but not GSTP1 | mechanism | BC/OC research |
| CYP19A1 | SIRT1 positively regulates breast cancer associated human aromatase (CYP19A1) expression | 23340254 | SIRT1 occupies the promoter regions PI.3/PII and PI.4, and its inhibition leads to increased acetylation of estrogen-related receptorα, a transcription factor that positively regulates CYP19A1 transcription in epithelial cells | mechanism | BC/OC research |
| CYP19A1 | Influence of CYP19A1 polymorphisms on the treatment of breast cancer with aromatase inhibitors: a systematic review and meta-analysis | 26067721 | The effects of CYP19A1 polymorphisms on clinical outcomes were most often detected in individual studies, suggesting that longer-term studies will better clarify these associations | mechanism | BC/OC research |
| CYP19A1 | The rs4646 and rs12592697 Polymorphisms in CYP19A1?Are Associated with Disease Progression among Patients with Breast Cancer from Different Racial/Ethnic Backgrounds | 27994616 | The rs4646 and the rs12592697 SNPs in CYP19A1 are associated with differences in disease progression in postmenopausal women. However, treatment appears to mitigate the differences in genetic risk. | mechanism | BC/OC research |
| CYP19A1 | Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERα metastatic breast cancer | 28112739 | AI treatment itself selects for acquired CYP19A1amp and promotes local autocrine estrogen signaling in AI-resistant metastatic patients | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| CYP19A1 | R-HSA-193144 | Reactome |
| CYP19A1 | R-HSA-211976 | Reactome |
| CYP19A1 | R-HSA-5579030 | Reactome |
| CYP19A1 | hsa00140:Steroid hormone biosynthesis | KEGG |
| CYP19A1 | hsa01100:Metabolic pathways | KEGG |
| CYP19A1 | hsa04913:Ovarian steroidogenesis | KEGG |
| CYP19A1 | Integrated Breast Cancer Pathway (Homo sapiens) | Wikipathway |
| CYP19A1 | Follicle Stimulating Hormone (FSH) signaling pathway (Homo sapiens) | Wikipathway |
| CYP19A1 | Metabolism of steroid hormones (Homo sapiens) | Wikipathway |
| CYP19A1 | Ovarian Infertility Genes (Homo sapiens) | Wikipathway |