ITGB7
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| ITGB7 | Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion | 21474670 | Our findings support a role for integrin-β7 in MM-cell adhesion, migration, and BM homing, and pave the way for a novel therapeutic approach targeting this molecule. | biomarker | BC/OC research |
| ITGB7 | Integrin β7-mediated regulation of multiple myeloma cell adhesion, migration, and invasion | 21474670 | ITGB7 knockdown inhibited focal adhesion kinase (FAK) and Src phosphorylation, Rac1 activation, and SUMOylation, reduced VEGF production in MM–BM stem cell cocultures and attenuated p65-NF-κB activity. | mechanism | BC/OC research |
| ITGB7 | β7 integrins contribute to intestinal tumor growth in mice. | 30235302 | Using chemically induced and spontaneous intestinal tumor models we showed that lack of β7 integrin significantly impairs tumor growth without affecting tumor frequencies, with a mild translatable effect on overall survival. | biomarker | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| ITGB7 | hsa05410:Hypertrophic cardiomyopathy (HCM) | KEGG |
| ITGB7 | PI3K-Akt Signaling Pathway (Homo sapiens) | Wikipathway |
| ITGB7 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway (Homo sapiens) | Wikipathway |
| ITGB7 | Focal Adhesion (Homo sapiens) | Wikipathway |
| ITGB7 | Arrhythmogenic Right Ventricular Cardiomyopathy (Homo sapiens) | Wikipathway |
| ITGB7 | Integrin-mediated Cell Adhesion (Homo sapiens) | Wikipathway |
| ITGB7 | Integrin cell surface interactions (Homo sapiens) | Wikipathway |
| ITGB7 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens) | Wikipathway |
| ITGB7 | hsa05414:Dilated cardiomyopathy | KEGG |
| ITGB7 | hsa05412:Arrhythmogenic right ventricular cardiomyopathy (ARVC) | KEGG |