DUSP1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| DUSP1 | DUSP1 is a novel target for enhancing pancreatic cancer cell sensitivity to gemcitabine | 24409315 | Gemcitabine-mediated upregulation of DUSP1 contributes to a negative feedback loop that attenuates its beneficial actions on stress pathways and apoptosis, raising the possibility that targeting DUSP1 in PDAC may have the advantage of enhancing gemcitabine chemosensitivity while suppressing angiogenesis | mechanism | BC/OC research |
| DUSP1 | Role of DUSP1/MKP1 in tumorigenesis, tumor progression and therapy | 27227569 | As a protein phosphatase, DUSP1 also downregulates p38?MAPKs and?JNKs signaling through directly dephosphorylating threonine and tyrosine. It has been detected that?DUSP1 is involved in various functions, including proliferation, differentiation, and apoptosis in normal cells. In various human cancers, abnormal expression of?DUSP1 was observed which was associated with prognosis of tumor patients | mechanism | BC/OC research |
| DUSP1 | DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer | 28129656 | The DUSP1-pERK-MMP2/VEGF signals may provide new biomarkers and/or therapeutic targets to better suppress GBC metastasis in the future | mechanism | BC/OC research |
| DUSP1 | DUSP1 enhances the chemoresistance of gallbladder cancer via the modulation of the p38 pathway and DNA damage/repair system | 30008878 | DUSP1 may be a promising target to overcome chemoresistance in GBC therapy | mechanism | BC/OC research |
| DUSP1 | DUSP1 is involved in the progression of small cell carcinoma of the prostate | 30108432 | DUSP1 is involved in the progression of SCCP and may provide a new therapeutic target for SCCP treatment | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| DUSP1 | R-HSA-112409 | Reactome |
| DUSP1 | hsa04010:MAPK signaling pathway | KEGG |
| DUSP1 | RAF/MAP kinase cascade (Homo sapiens) | Wikipathway |
| DUSP1 | MAPK Signaling Pathway (Homo sapiens) | Wikipathway |