EPCAM
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| EPCAM | Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells | 25205054 | EpCAM may be an attractive strategy to treat breast cancer.This study implicates the potential value of EpCAM as a molecular marker for breast cancer. | biomarker | BC/OC research |
| EPCAM | Epithelial-to-mesenchymal transition induced by TGF-β1 is mediated by AP1-dependent EpCAM expression in MCF-7 cells | 25205054 | EpCAM participated in TGF-β1-induced EMT. TGF-β1 treatment of MCF-7 breast cancer cells was shown to induce EpCAM expression, which promoted the EMT and cell migration. EpCAM overexpression further enhanced TGF-β1-induced EMT and EpCAM knockdown inhibited TGF-β1-induced EMT. We further demonstrated that TGF-β1 treatment induced the phosphorylation of JNK that was in turn responsible for the increased expression of Jun and Fos. This result suggests an important role of the JNK to AP-1 signaling to EpCAM downstream of TGF-β1 for the induction of EMT in the breast cancer cells. | mechanism | BC/OC research |
| EPCAM | By inhibiting Ras/Raf/ERK and MMP-9, knockdown of EpCAM inhibits breast cancer cell growth and metastasis | 26356670 | Overexpression of EpCAM in breast cancer cells enhanced tumor cell growth in vitro and increased invasiveness, whereas small interfering RNA-mediated silencing of EpCAM (si-EpCAM) had the opposite effect. EpCAM knockdown led to decreased phosphorylation of Raf and ERK, suppression of malignant behavior of breast cancer cells, and inhibition of the Ras/Raf/ERK signaling pathway. | mechanism | BC/OC research |
| EPCAM | EpCAM and COX?2 expression are positively correlated in human breast cancer | 28393249 | EpCAM may serve a role in the regulation of cancer cell growth and may hold potential as a prognostic marker in breast cancer. | biomarker | BC/OC research |
| EPCAM | Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC | 21293856 | Tumour-derived exosomes interfere with the tumour-specific function of immune cells and constitute an additional mechanism how tumours escape from immune surveillance | mechanism | BCEXO research |
Survival analysis