DOK1
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| DOK1 | Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer | 21856257 | These analyses were also indicative for DOK1 protective role in EOC tumorigenesis, linked to DOK1-mediated induction of some tumor suppressor factors and its suppression of pro-metastasis genes | mechanism | BC/OC research |
| DOK1 | Transcriptional regulation of the human tumor suppressor DOK1 by E2F1 | 23028047 | E2F1 is a key factor in DOK1 expression and provide novel insights into the regulation of these events in cancer cells | mechanism | BC/OC research |
| DOK1 | BRK Targets Dok1 for Ubiquitin-Mediated Proteasomal Degradation to Promote Cell Proliferation and Migration | 24523872 | A novel mechanism of action of BRK in the promotion of tumor formation, which involves the targeting of tumor suppressor Dok1 for degradation through the ubiquitin proteasomal pathway | mechanism | BC/OC research |
| DOK1 | A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling | 24762811 | Knockdown of DOK1 and Rap1 inhibited PDGF-BB-induced chemotactic cell migration, and knockdown of DOK1 and Rap1 and expression of DOK1FF inhibited PDGF-mediated three-dimensional (3D) spheroid invasion | mechanism | BC/OC research |
| DOK1 | Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells | 27183638 | Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation | mechanism | BC/OC research |
| DOK1 | Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer | 27428427 | DOK1 was identified as a prognostic factor for non-metastatic CRC, and, via its drugability by PPARĪ³-agonist, may constitute a potential target for future cancer treatments | biomarker | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| DOK1 | hsa05162:Measles | KEGG |
| DOK1 | Kit receptor signaling pathway (Homo sapiens) | Wikipathway |
| DOK1 | Signaling by PTK6 (Homo sapiens) | Wikipathway |
| DOK1 | VEGFA-VEGFR2 Signaling Pathway (Homo sapiens) | Wikipathway |
| DOK1 | RET signaling (Homo sapiens) | Wikipathway |