KRT14
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| KRT14 | Collective invasion in breast cancer requires a conserved basal epithelial program | 24332913 | Similarly, KRT14-expressing breast cancer cells are only capable of leading invasion through a stromal ECM that is rich in fibrillar collagen and deficient in collagen IV? | mechanism | BC/OC research |
| KRT14 | Identification of Distinct Basal and Luminal Subtypes of Muscle-Invasive Bladder Cancer with Different Sensitivities to Frontline Chemotherapy | 24525232 | ΔNp63α knockdown in human bladder or breast cancer cells result in down regulated expression of basal biomarkers such as CD44, KRT5, KRT14, and CDH3 | mechanism | BC/OC research |
| KRT14 | Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters | 26831077 | To dissect this list further, we next ranked genes by their association with Krt14 transcript levels [487 genes at a false-discovery rate (FDR) < 0.05]. The top four genes most correlated with?Krt14?transcript expression were enriched for multiple major metastasis effector genes that promote metastatic niche remodeling (Tnc,?AdamTs1,?Jag1) and metastasis survival | mechanism | BC/OC research |
| KRT14 | Foxa1 is essential for mammary duct formation | 26919034 | A potentially powerful model for complete ablation of Foxa1 in mammary epithelial cells using Krt14-driven Cre expression in an inducible manner, such as Krt14-rtTA;Tet-On-Cre | mechanism | BC/OC research |
| KRT14 | Normal Breast-Derived Epithelial Cells with Luminal and Intrinsic Subtype-Enriched Gene Expression Document Interindividual Differences in Their Differentiation Cascade | 29997232 | RNA-seq and PAM50-intrinsic subtype clustering identified these cell lines as the "normal" counterparts of luminal A, basal, and normal-like subtypes and validated via immunostaining with basal-enriched KRT14 and luminal-enriched KRT19 | mechanism | BC/OC research |
| KRT14 | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential | 29115712 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| KRT14 | R-HSA-446107 | Reactome |