RAB13
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| RAB13 | Regulation of Cancer Cell Behavior by the Small GTPase Rab13 | 27044746 | Rabs have been implicated in all steps of membrane trafficking ranging from vesicle formation and transport to vesicle docking/tethering and fusion. Vesicle trafficking controls the localization and levels of a myriad of proteins, thus regulating cellular functions including proliferation, metabolism, cell-cell adhesion, and cell migration | mechanism | BC/OC research |
| RAB13 | Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT | 29483957 | Rab13 is activated by its effector MICAL-L2 to recruit actin-binding proteins to promote migrating cell | mechanism | BC/OC research |
| RAB13 | RAB13 as a novel prognosis marker promotes proliferation and chemotherapeutic resistance in gastric cancer | 31474334 | RAB13 promotes the proliferation and confers CDDP and 5-FU resistance to GC cells, which provides experimental support to target this protein in future clinical practice | mechanism | BC/OC research |
| RAB13 | Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing | 24255815 | RAB13 distinguish exosomes produced by low metastatic breast cancer cell line (MDA-MB-436) from that produced by highly metastatic breast cancer cell line (MDA-MB-231) | mechanism | BCEXO research |
| RAB13 | Rab35 promotes the recruitment of Rab8, Rab13 and Rab36 to recycling endosomes through MICAL-L1 during neurite outgrowth | 25086062 | We further showed by functional ablation experiments that each of these downstream Rabs regulates neurite outgrowth in a non-redundant manner downstream of Rab35 and MICAL-L1, e.g. by showing that knockdown of Rab36 inhibited recruitment of Rab36-specific effector JIP4 to Arf6-positive recycling endosomes, and caused inhibition of neurite outgrowth without affecting accumulation of Rab8 and Rab13 in the same Arf6-positive area | mechanism | BC/OC research |
| RAB13 | DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior | 25713415 | Blocking Rab13 activation by DENND2B may provide a novel target to limit the spread of epithelial cancers | mechanism | BC/OC research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| RAB13 | R-HSA-1445148 | Reactome |
| RAB13 | R-HSA-1445148 | Reactome |
| RAB13 | hsa04530:Tight junction | KEGG |
| RAB13 | miR-targeted genes in adipocytes - TarBase (Homo sapiens) | Wikipathway |
| RAB13 | miR-targeted genes in epithelium - TarBase (Homo sapiens) | Wikipathway |
| RAB13 | miR-targeted genes in leukocytes - TarBase (Homo sapiens) | Wikipathway |
| RAB13 | miR-targeted genes in lymphocytes - TarBase (Homo sapiens) | Wikipathway |
| RAB13 | miR-targeted genes in muscle cell - TarBase (Homo sapiens) | Wikipathway |
| RAB13 | trans-Golgi Network Vesicle Budding (Homo sapiens) | Wikipathway |
| RAB13 | Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens) | Wikipathway |