FRS2
Submitted by Anonymous on Wed, 10/30/2019 - 22:16
Pubmed
| Gene symble | Title | PMID | Curated descirption | Category | Literature category |
|---|---|---|---|---|---|
| FRS2 | MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy | 27533459 | MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor-positive breast cancer patients receiving tamoxifen as an adjuvant endocrine therapy | biomarker | BC/OC research |
| FRS2 | MiR-4653-3p and its target gene FRS2 are prognostic biomarkers for hormone receptor positive breast cancer patients receiving tamoxifen as adjuvant endocrine therapy | 27533459 | Fibroblast growth factor receptor substrate 2 (FRS2, also known as FRS2alpha) is a member of the adaptor/scaffold protein family. It was considered as an essential “conning center” in FGFR signaling . FSR2 binds through its N-terminal phosphotyrosine-binding domain (PTB) to FGFR, resulting in phosphorylation of multiple tyrosine residues of FRS2 and subsequent activation of the downstream signaling (e.g., RAS/MAPK/ERK, PI3K/AKT/mTOR) and ubiquitination/degradation pathways . FRS2 acts as an oncogene in a variety of cancers, which regulates tumor cell differentiation, proliferation, and tumorigenesis . Inhibition of FRS2 could block the FGFR signaling and downstream biological functions | mechanism | BC/OC research |
| FRS2 | Targeting FGFR pathway in breast cancer | 29156384 | Activated FRS2 promotes downstream signaling through the RAS–mitogen-activated protein kinase (MAPK) or the phosphoinositide 3-kinase (PI3K)–AKT pathways that regulate cell proliferation, differentiation, and survival | mechanism | BC/OC research |
| FRS2 | Proteomic Profiling of Exosomes Secreted by Breast Cancer Cells with Varying Metastatic Potential | 29115712 | Presumably aid in targeting the primary cancer cells to specific metastatic sites | mechanism | BCEXO research |
Survival analysis
Pathway
| Pathway Term | Reference DB | |
|---|---|---|
| FRS2 | R-HSA-5655253 | Reactome |
| FRS2 | R-HSA-5654720 | Reactome |
| FRS2 | R-HSA-5654726 | Reactome |
| FRS2 | R-HSA-5654727 | Reactome |
| FRS2 | R-HSA-5654732 | Reactome |
| FRS2 | R-HSA-5654733 | Reactome |
| FRS2 | R-HSA-5673001 | Reactome |
| FRS2 | hsa05205:Proteoglycans in cancer | KEGG |
| FRS2 | hsa04722:Neurotrophin signaling pathway | KEGG |
| FRS2 | R-HSA-5654719 | Reactome |